BA25 - Leukocyte telomere dynamics, cardiovascular aging and survival in the WHI Long Life Study in the WHI Long Life Study
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| NameBA25PhaseII_selectionsummary_20150521 (2).docx | Description |
| NameBA25SampleSelection_Final.docx | Description |
Related Papers
Leukocyte telomere length, T cell composition and DNA methylation age
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age- the extrinsic epigenetic age acceleration (EEAA)- is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanMethylation450 BeadChip in participants in the Women's Health Initiative (WHI; n=804), the Framingham He...
Keywords: Dna Methylation; Epigenetic; Aging
Associations of accelerometer-measured and self-reported sedentary time with leukocyte telomere length in older women
Few studies have assessed the association of sedentary time with leukocyte telomere length (LTL). In a cross-sectional study conducted in 2012–2013, we examined associations of accelerometer-measured and selfreported sedentary time with LTL in a sample of 1,481 older white and African-American women from the Women’s Health Initiative and determined whether associations varied by level of moderate- to vigorousintensity physical activity (MVPA). The association between sedentary time and LTL was e...
Keywords: Accelerometry; Leukocyte Telomere Length; Moderate- To Vigorous-Intensity Physical Activity; Sedentary Time; Telomeres
Related Studies: BA25
GWAS meta-analysis of leukocyte telomere length in whites and African Americans
Keywords: Telomere Length; Aging; Genetics; Gwas; African Americans
Related Studies: BA25
Association of pain with leukocyte telomere length among women
Keywords: Pain; Telomere; Aging; Biomarker
Related Studies: BA25
Sleep behavior and long-term leukocyte telomere attrition in the Women’s Health Initiative
Related Studies: BA25
Associations between leukocyte telomere length and heart failure subtypes in a multiracial cohort of postmenopausal women
Keywords: Leukocyte Telomere Length; Heart Failure; Postmenopausal Woman; Race
Related Studies: BA25
Leukocyte telomere length and risks of incident coronary heart disease and mortality in a racially diverse population of postmenopausal women
Telomeres are regions at the ends of chromosomes that maintain chromosomal structural integrity and genomic stability. In studies of mainly older, white populations, shorter leukocyte telomere length (LTL) is associated with cardiometabolic risk factors and increased risks of mortality and coronary heart disease (CHD). On average, African Americans (AfAm) have longer LTL than whites, but the LTL-CHD relationship in AfAm is unknown. We investigated the relationship of LTL with CHD and mortality a...
Keywords: Leukocyte Telomore; Cardiovascular Aging
Related Studies: BA25
Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies
Abstract Importance: Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major disease categories that largely define longevity in the United States. However, it remains unclear whether LTL is associated with the human life span. Objective: To examine whether LTL is associated with the life span of contemporary humans. Design, Setting, and Participants: This cohort study included 3259 adults of European ancestry from the Cardiovascular Heal...
Keywords: Telomere Length; Aging; Cardiovascular Disease; Mortality; Cardiovascular Disease Risk Factors
Related Studies: BA25
A cross-sectional analysis of telomere length and sleep in the Women’s Health Initiative
Telomere length is a heritable marker of cellular age that is associated with morbidity and mortality. Poor sleep behaviors, which are also associated with adverse health events, may be related to leukocyte telomere length (LTL). We studied a sub-population of 3,145 postmenopausal women enrolled 1993-1998 to the Women's Health Initiative (1,796 European American (EA), 1,349 African American (AA)) with Southern-blot measured LTL and self-reported usual sleep duration and sleep disturbance. LTL-sl...
Keywords: Sleep; Sleep Quality; Sleep Duration; Telomere Length; Leukocyte Telomere Length; Ltl
Related Studies: BA25
Leisure-time physical activity and leukocyte telomere length among older women
BACKGROUND: Shortened leukocyte telomere length (LTL), a purported marker of cellular aging, is associated with morbidity and mortality. However, the association of physical activity, a modifiable lifestyle behavior, with LTL has not been adequately studied among older adults. METHODS: In this cross-sectional study, we examined associations of various intensity levels of leisure-time physical activity with LTL among 1476 older white and African American women from the Women's Health Initiative O...
Keywords: Leukocyte Telomere Length; Mvpa; Older Adults; Physical Activity; Walking
Related Studies: BA25
The association of leukocyte telomere length with exceptional longevity among older women
The association of leukocyte telomere length (LTL) with survival to late life with intact mobility has not been adequately studied. This prospective cohort study consisted of 1451 postmenopausal women from a Women's Health Initiative ancillary study, who were eligible, because of birth year, to survive to age 90 as of March 6, 2021. LTL was measured by Southern blot at baseline (1993-1998). Associations between LTL and survival to age 90 were evaluated using logistic regression models adjusted f...
Keywords: Leukocyte Telomere Length; Longevity; Intact Mobility; Survival To Age 90; Aging
Related Studies: BA25
