AS254 - Telomere and its biochemical and genetic regulators as predictors for clinical diabetes in women diabetes in women
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| NameAS254 Selection Summary 7-7-09.pdf | Description |
Related Papers
Unhealthy lifestyle in relation to peripheral leukocyte telomere length in postmenopausal women
Keywords: Telomere Length; Dietary Factors; Oxidative Stress; Antioxidants; Nutrient
Related Studies: 254
Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women
Dietary factors, including dietary fat, may affect the biological aging process, as reflected by the shortening of telomere length (TL), by affecting levels of oxidative stress and inflammatory responses. We examined the direct relations of total and types of dietary fats and fat-rich foods to peripheral leukocyte TL. In 4029 apparently healthy postmenopausal women who participated in the Women's Health Initiative, intakes of total fat, individual fatty acids, and fat-rich foods were assessed by...
Keywords: Telomere Length; Dietary Factors; Fatty Acids; Fat; Nutrient
Related Studies: 254
The portfolio diet and incident type 2 diabetes: Findings from the Women's Health Initiative prospective cohort study
Objective: A plant-based dietary pattern, the Portfolio Diet, has been shown to lower LDL cholesterol and other cardiovascular disease risk factors. However, no study has evaluated the association of this diet with incident type 2 diabetes. Research design and methods: This analysis included 145,299 postmenopausal women free of diabetes at baseline in the Women's Health Initiative (WHI) Clinical Trials and Observational Study from 1993 to 2021. Adherence to the diet was assessed with a score bas...
Keywords: Portfolio Diet; Cardiovascular Disease; Prospective Cohort; Nutritional Epidemiology; Dietary Patterns
Physical activity, mediating biomarkers and development of type 2 diabetes: Assessing mediation of biological pathways in a prospective cohort of multi-ethnic women
Keywords: Leisure-Time Physical Activity; Telomere Length; Type 2 Diabetes
Related Studies: 254
Optimism, pessimism, cynical hostility, and diabetes in AS254
Keywords: Optimism; Pessimism; Cynical Hostility; Inflammatory Biomarkers; Diabetes; Cardiovascular Disease
Related Studies: 254
Optimism, pessimism, cynical hostility, and biomarkers of metabolic function in the Women's Health Initiative
BACKGROUND: Psychological attitudes reflecting expectations about the future (optimism, pessimism) and people (cynical hostility) independently predict incident cardiovascular disease and possibly diabetes, but underlying biologic pathways are incompletely understood. We examined the cross-sectional relationship between optimism, pessimism, and cynicism and biomarkers of metabolic function in the Women's Health Initiative. METHODS: Among 3443 postmenopausal women, biomarkers of metabolic functio...
Keywords: Cynical Hostility; Diabetes; Insulin Resistance; Optimism; Pessimism
The Relation of Optimism to Relative Telomere Length in Older Men and Women
Objective: Mounting evidence suggests that higher optimism is associated with reduced risk of age-related morbidities and premature mortality. However, possible biological mechanisms underlying these associations remain understudied. One hypothesized mechanism is a slower rate of cellular aging, which in turn delays age-related declines in health. Methods: We used data from two large cohort studies to test the hypothesis that higher optimism is associated with longer leukocyte telomere length. W...
Keywords: Telomere Length; Optimism; Aging; Biology; Epidemiology
A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women
Telomere length (TL) has been implicated in the pathogenesis of age-related disorders. However, there are no prospective studies directly investigating the role of TL and relevant genes in diabetes development. In the multiethnic Women's Health Initiative, we identified 1,675 incident diabetes case participants in 6 years of follow-up and 2,382 control participants matched by age, ethnicity, clinical center, time of blood draw, and follow-up duration. Leukocyte TL at baseline was measured using ...
Keywords: Telomere Length; Diabetes Mellitus; Inflammation; Endothelial Dysfunction
Related Studies: 254
Birthweight, mediating biomarkers and the development of type 2 diabetes later in life: a prospective study of multi-ethnic women
AIMS/HYPOTHESIS: The aim of this work was to investigate the prospective relationship between low birthweight (LBW) and type 2 diabetes risk later in life and the mediation effects of type 2 diabetes biomarkers linking LBW to type 2 diabetes risk. METHODS: We measured baseline plasma concentrations of various type 2 diabetes biomarkers in 1,259 incident type 2 diabetes cases and 1,790 controls in the Women's Health Initiative-Observational Study. Self-report birthweights of the participants were...
Keywords: Birth Weight; Type 2 Diabetes; Insulin Resistance; Telomere; Inflammation; Endothelial Dysfunction; Sex Steroid
Relations of sex hormone levels to leukocyte telomere length in black, hispanic, and asian/Pacific Islander postmenopausal women
BACKGROUND: Sex hormones may play important roles in sex-specific biological aging. We specifically examined the associations between circulating concentrations of sex hormones and leukocyte telomere length (TL). METHODS: We conducted a cross-sectional study of 1124 black, 444 Hispanic, and 289 Asian/Pacific Islander women in the Women's Health Initiative Observational Cohort. Concentrations of estradiol and testosterone were measured using electrochemiluminescence immunoassays. TL was measured ...
Keywords: Aging; Estradiol; Sex Steroid Hormones; Telomere Length; Testosterone
