Ancillary Studies

Major Ancillary Studies

These are a few of the larger WHI ancillary studies. See a list of all studies

COcoa Supplement and Multivitamin Outcomes Study (COSMOS)

A clinical trial that will randomize approximately 22,000 men and women across the U.S. The study will investigate whether taking daily supplements of cocoa flavanols (600 mg/day) or a common multivitamin reduces the risk for developing heart disease, stroke, and cancer.

Study details...

WHI Life and Longevity After Cancer

The WHI Life and Longevity After Cancer (LILAC) Study was funded by the National Cancer Institute with study goals of enrolling WHI participants who have been diagnosed with cancer into a cancer survivorship cohort and then examining factors that may affect life and longevity among women who have been diagnosed with cancer.

Study details...

WHI Memory Study (WHIMS)

WHIMS was an ancillary study to the WHI Hormone Trials and enrolled 7,427 women aged 65 years and older. WHIMS investigated the effects of hormone supplementation on risk of probable dementia and any cognitive impairment and on changes in global cognition over time.

Study details...

Objective Physical Activity and Cardiovascular Health in Older Women (OPACH)

The OPACH study was an ancillary study of the WHI Long Life Study. Long Life Study participants who were ambulatory were concurrently invited to join the OPACH study. The goal of OPACH was to increase the understanding of the health benefits and risks of physical activity, specifically with cardiovascular events and incident falls.

Study details...

Women’s Health Initiative Sleep Hypoxia Effects on Resilience – WHISPER

The WHISPER study examines whether sleep-disordered breathing and the resulting low blood oxygen are associated with increased risks of health events, including heart attack, stroke, heart failure, cancer, and cognitive decline.

Study details...

All Funded and Approved Studies

PI Name
Funding Agency
Grant Number
Id753NameTOPMed X01 – Omics resources for Women's Health Initiative African American women cardiovascular health researchPI NameKooperberg,CharlesStatusApprovedFunding AgencyGrant NumberDatafilesN
Id752NameClonal hematopoiesis of indeterminate potential in aging and exceptional longevityPI NameReiner,AlexanderStatusApprovedFunding AgencyGrant NumberDatafilesN
Id748NameCirculating immune checkpoint proteins and the early detection of gynecologic cancersPI NameMichels,KaraStatusApprovedFunding AgencyGrant NumberDatafilesN
Id747NameMetabolomics and the Prospective analysis of age-related macular degeneration and the structural integrity of the retinaPI NameMillen,AmyStatusApprovedFunding AgencyGrant NumberDatafilesN
Id742NameTRAJECTORY Study: Changing generational trajectory of cardiovascular disease with the adult children and grandchildren of the Women’s Health Initiative studyPI NameBreathett,KhadijahStatusFundedFunding AgencyGrant NumberDatafilesN
Id741NameImpact of genetic susceptibility on colorectal tumor immune profilePI NameThomas,ClaireStatusApprovedFunding AgencyGrant NumberDatafilesN
Id740NameFracture risk assessment among older adults with diabetesPI NameLee,RichardStatusApprovedFunding AgencyGrant NumberDatafilesN
Id739NameCardiovascular disease, preeclampsia, and fetal microchimerismPI NameShree,RajStatusApprovedFunding AgencyGrant NumberDatafilesN
Id738NameBlood protein biomarkers for colorectal cancer etiology, prevention, and disparityPI NameMurphy,NeilStatusApprovedFunding AgencyGrant NumberDatafilesN
Id737NameDefining the clinical characteristics of inflammatory and insulinemic dietary patterns using feeding study dietary data and blood biomarkersPI NameTabung,FredStatusApprovedFunding AgencyGrant NumberDatafilesN