Ancillary Studies

Major Ancillary Studies

In addition to the main WHI studies, several ancillary studies have enrolled or are currently enrolling WHI participants. A few of the larger WHI ancillary studies are described below.

COcoa Supplement and Multivitamin Outcomes Study (COSMOS)

A clinical trial that will randomize approximately 22,000 men and women across the U.S. The study will investigate whether taking daily supplements of cocoa flavanols (600 mg/day) or a common multivitamin reduces the risk for developing heart disease, stroke, and cancer.

Study details...

WHI Life and Longevity After Cancer

The WHI Life and Longevity After Cancer (LILAC) Study was funded by the National Cancer Institute with study goals of enrolling WHI participants who have been diagnosed with cancer into a cancer survivorship cohort and then examining factors that may affect life and longevity among women who have been diagnosed with cancer.

Study details...

WHI Memory Study (WHIMS)

WHIMS was an ancillary study to the WHI Hormone Trials and enrolled 7,427 women aged 65 years and older. WHIMS investigated the effects of hormone supplementation on risk of probable dementia and any cognitive impairment and on changes in global cognition over time.

Study details...

Objective Physical Activity and Cardiovascular Health in Older Women (OPACH)

The OPACH study was an ancillary study of the WHI Long Life Study. Long Life Study participants who were ambulatory were concurrently invited to join the OPACH study. The goal of OPACH was to increase the understanding of the health benefits and risks of physical activity, specifically with cardiovascular events and incident falls.

Study details...

Women’s Health Initiative Sleep Hypoxia Effects on Resilience – WHISPER

The WHISPER study examines whether sleep-disordered breathing and the resulting low blood oxygen are associated with increased risks of health events, including heart attack, stroke, heart failure, cancer, and cognitive decline.

Study details...

All Funded and Approved Studies

IdNamePI NameStatusFunding AgencyGrant NumberDatafiles
689Helicobacter infection and liver cancer risk among African Americans and Whites in the United States Zhang, XuehongApprovedN
688The role of the social environment in the association between air pollution and cardiovascular diseaseHajat, AnjumApprovedN
687Determinants of the racial/ethnic disparity in MGUS risk: An epidemiologic study in 4 cohortsDesai, PinkalApprovedN
685Genome-wide enrichment of functionally important alleles and association studies of metabolic traits in Pacific Island populationsChiang, CharlestonApprovedN
682Methylmercury exposure and risk of renal cell carcinomaLuo, JuhuaApprovedN
679Perfluoroalkyl Substances (PFASs) and Liver Cancer Risk in the United StatesZhang, XuehongApprovedN
677ConfluenceLindstroem, SaraApprovedN
674Endocrine disrupting chemicals and postmenopausal breast cancer riskReeves, KatherineApprovedN
673DNA methylation as a novel epigenetic biomarker that regulates metabolic and inflammatory cytokines in the development of obesity-attributable cancersJung, Su YonApprovedN
671Infection-based markers of glioma risk in the NCI Cohort ConsortiumEgan, KathleenApprovedN