Vision

WHI strives to improve health through research on risk factors, prevention, and early detection of serious health conditions, so postmenopausal women thrive.

Learn more
VisionVision

Impacting lives through groundbreaking research

Impacting lives through groundbreaking research
161,000 +study participants
Dive into the dataRead More
5.3 millionspecimen vials collected and documented
Explore available biospecimensSee Details
12,600fewer cases of breast cancer each year as a result of WHI research
Read the paperSee Manuscript

The Women’s Health Initiative is a landmark study that has had a huge impact on medical practice and public health.

— Gary H. Gibbons, M.D., NHLBI Director
See the impactReview Timeline
2,335papers published to date using WHI datapapers published using WHI data
Browse the publication database View Papers

WHI News

2023 WHI Investigators Meeting

2023 WHI Investigators Meeting

3/14/2023
Registration is now open for the 2023 WHI Investigators Meeting! Please see the attached link for registration information. More details to follow.
WHI Response to NYT article "Women have been misled about menopause"

WHI Response to NYT article "Women have been misled about menopause"

2/15/2023
On February 1st, the NYT Magazine published an article describing some perimenopausal women’s struggles with menopause and the role of hormone therapy in relieving symptoms. The WHI hormone trials are cast in a rather unfavorable light in this article, mostly because the trial was not designed to address the concerns of perimenopausal women. The WHI Steering Committee has written a letter to the editor of the NYT in response, which can be found below.
Remembering Dr. Lewis Kuller - MEMORIAL INFO AVAILABLE

Remembering Dr. Lewis Kuller - MEMORIAL INFO AVAILABLE

2/2/2023
What a difficult year this has been for us. Sadly, we must inform you of the passing of one of the major intellectual leaders in the WHI. Dr. Lewis Kuller passed away last night after some months of declining health.
Want more stories? Please check out the news archive. Have news to share? Please send us an e-mail!

Recent Publications

Association of social support with mild cognitive impairment and dementia among older women: Women’s Health Initiative Memory Study

Alexander Posis et al., 2023/undefined PubMed #36565123

Association of macular pigment optical density with retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma

Yao Liu et al., 2023/10 PubMed #37890895

Cocoa extract supplementation and risk of Type 2 Diabetes: The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) Randomized Clinical Trial

Jie Li et al., 2023/10 PubMed #37816167

Associations between ambient air pollutants and clonal hematopoiesis of indeterminate potential (CHIP)

Claire Leiser et al., 2023/10 PubMed #37466697

The association of leukocyte telomere length with exceptional longevity among older women

Nhat Thai et al., 2023/10 PubMed #37843740

Psychometric analysis of the modified differential emotions scale and the six-item life orientation test-revised in a cohort of older women from the Women's Health Initiative

Alexander Posis et al., 2023/9 PubMed #37449819

Association of dietary insulinemic and inflammatory potential with risk of liver cancer and chronic liver disease mortality in postmenopausal women: a prospective cohort study

Xinyuan (Cindy) Zhang et al., 2023/9 PubMed #37460062

Association of dietary insulinemic and inflammatory potential with risk of liver cancer and chronic liver disease mortality in postmenopausal women: a prospective cohort study

Xuehong Zhang et al., 2023/9 PubMed #37460062

Changes in physical function in older women with endometrial cancer with or without adjuvant therapy

Allison Quick et al., 2023/9 PubMed #37668940

Association between insomnia, stress events and other psychosocial factors and incident atrial fibrillation in postmenopausal women: Insights from the Women's Health Initiative

Susan Zhao et al., 2023/9 PubMed #37646212

Long‑term breast cancer incidence trends by mammography, obesity, and menopausal hormone therapy

Rowan Chlebowski et al., 2023/9 PubMed #37728692

Validating a model for predicting breast cancer and non-breast cancer death in women aged 55 and older

Mara Schonberg et al., 2023/9 PubMed #37676833

Association of type 2 diabetes mellitus with dementia-related and non-dementia-related mortality among postmenopausal women: A secondary competing risks analysis of the women's health initiative

Tyler Titcomb et al., 2023/8 PubMed #37563765

Energy-adjusted dietary inflammatory index and diabetes risk in postmenopausal Hispanic Women

Monica Daniela Zuercher et al., 2023/8 PubMed #37544374

Differences in the circulating proteome in individuals with versus without sickle cell trait

Yanwei Cai et al., 2023/8 PubMed #37533140

Metabolomic profiles of chronic distress are associated with cardiovascular disease risk and inflammation-related risk factors

Katherine Shutta et al., 2023/8 PubMed #37557964

Derivation and external validation of a risk score for clinically important declines in health and function among two longitudinal cohorts of women in the mid-life

Daniel Solomon et al., 2023/8 PubMed #37563237

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study

Dan Levy et al., 2023/8 PubMed #37563237

Previous fracture and subsequent fracture risk: A meta-analysis to update FRAX

John A. Kanis et al., 2023/8 PubMed #37566158

Age at menopause, leukocyte telomere length, and coronary artery disease in postmenopausal women

Michael Honigberg et al., 2023/8 PubMed #37489536

Association of later life weight changes with survival to ages 90, 95, and 100: The Women’s Health Initiative

Aladdin Shadyab et al., 2023/8 PubMed #37642339

Menopausal hormone therapy and change in physical activity in the Women’s Health Initiative Hormone Therapy Clinical Trials

Rita Peila et al., 2023/8 PubMed #37527476

Regression calibration utilizing biomarkers developed from high-dimensional metabolites

Yiwen Zhang et al., 2023/8 PubMed #37599686

Association of maternal birth weight and maternal preterm birth with subsequent risk for adverse reproductive outcomes: The Women’s Health Initiative

Cassandra Spracklen et al., 2023/8 PubMed #37549575

Bilateral oophorectomy and colorectal cancer incidence and mortality in the Women's Health Initiative

Mihae Song et al., 2023/8 PubMed #37566400

Biomarkers of glucose homeostasis as mediators of the relationship of body mass index and waist circumference with COVID-19 outcomes among postmenopausal women from the Women’s Health Initiative

Hind Beydoun et al., 2023/7 PubMed #37523800

Genome-wide association study of Red Blood Cell fatty acids in the Women’s Health Initiative Memory Study

Nathan Tintle et al., 2023/7 PubMed #37285607

Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype

Ira Driscoll et al., 2023/7 PubMed #37438877

Adverse pregnancy outcomes and risk of type 2 diabetes in the Women’s Health Initiative

Kexin Zhu et al., 2023/7 PubMed #37490991

Birth weight, adult body size, and risk of colorectal cancer

Le Su et al., 2023/7 PubMed #37413805

Want to view more works by WHI investigators? Visit our publications page