AS238 - Biochemical predictors of type 2 diabetes mellitus in women
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| NameAS238 - see AS132Matching Summary.pdf | Description |
Related Papers
Relation of dietary carbohydrates intake to circulating sex hormone-binding globulin levels in postmenopausal women
BACKGROUND: Low circulating levels of sex hormone-binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone-dependent cancers, although the relation between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies. METHODS: Among postmenopausal women with available SHBG measurements at baseline (n = 11,159) in the Women's Health Initiative, we conducted a comprehensive assessmen...
Keywords: Dietary Carbohydrates; Glycemic Index; Glycemic Load; Sex Hormone Binding Globulin (Shbg); Type 2 Diabetes
Associations of sex-steroid hormones levels and exogenous estrogen use with changes in body fat distribution and body mass
Keywords: Sex-Steroid Hormones; Sex Hormone-Binding Globulin; Hormone-Replacement Therapy
Related Studies: 238
Leptin and soluble leptin receptor and risk of clinical diabetes in African-American, Hispanic, and Asian postmenopausal women
Keywords: Leptin; Soluble Leptin Receptor; Postmenopausal Women; African American; Hispanic; Asian; Type 2 Diabetes
Related Studies: 238
Sex hormones, sex hormones binding globulin (SHBG), and risk of ischemic stroke in men and women in WHI and TOPMed Stroke
Keywords: Stroke; Sex Hormone Binding Globulin; Mendelian Randomization; Single Nucleotide Polymorphisms; Ischemic Stroke
The portfolio diet and incident type 2 diabetes: Findings from the Women's Health Initiative prospective cohort study
Objective: A plant-based dietary pattern, the Portfolio Diet, has been shown to lower LDL cholesterol and other cardiovascular disease risk factors. However, no study has evaluated the association of this diet with incident type 2 diabetes. Research design and methods: This analysis included 145,299 postmenopausal women free of diabetes at baseline in the Women's Health Initiative (WHI) Clinical Trials and Observational Study from 1993 to 2021. Adherence to the diet was assessed with a score bas...
Keywords: Portfolio Diet; Cardiovascular Disease; Prospective Cohort; Nutritional Epidemiology; Dietary Patterns
The Relation of Optimism to Relative Telomere Length in Older Men and Women
Objective: Mounting evidence suggests that higher optimism is associated with reduced risk of age-related morbidities and premature mortality. However, possible biological mechanisms underlying these associations remain understudied. One hypothesized mechanism is a slower rate of cellular aging, which in turn delays age-related declines in health. Methods: We used data from two large cohort studies to test the hypothesis that higher optimism is associated with longer leukocyte telomere length. W...
Keywords: Telomere Length; Optimism; Aging; Biology; Epidemiology
Optimism, pessimism, cynical hostility, and biomarkers of metabolic function in the Women's Health Initiative
BACKGROUND: Psychological attitudes reflecting expectations about the future (optimism, pessimism) and people (cynical hostility) independently predict incident cardiovascular disease and possibly diabetes, but underlying biologic pathways are incompletely understood. We examined the cross-sectional relationship between optimism, pessimism, and cynicism and biomarkers of metabolic function in the Women's Health Initiative. METHODS: Among 3443 postmenopausal women, biomarkers of metabolic functio...
Keywords: Cynical Hostility; Diabetes; Insulin Resistance; Optimism; Pessimism
The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women
OBJECTIVES: Higher body mass index (BMI) is an important risk factor for atrial fibrillation (AF). The adipokines leptin, adiponectin and resistin are correlates of BMI, but their association with incident AF is not well known. We explored this relationship in a large cohort of postmenopausal women. METHODS: We studied an ethnically diverse cohort of community-dwelling postmenopausal women aged 50-79 who were nationally recruited at 40 clinical centres as part of the Women's Health Initiative in...
Keywords: Atrial Fibrillation; Cardiac Arrhythmia
Sex hormone-binding globulin and risk of clinical diabetes in American Black, Hispanic, and Asian/Pacific Islander postmenopausal women
Recent prospective studies have shown a strong inverse association between sex hormone-binding globulin (SHBG) concentrations and risk of clinical diabetes in white individuals. However, it remains unclear whether this relationship extends to other racial/ethnic populations.We evaluated the association between baseline concentrations of SHBG and clinical diabetes risk in the Women's Health Initiative Observational Study. Over a median follow-up of 5.9 years, we identified 642 postmenopausal wome...
Keywords: Sex Hormone-Binding Globulin; Shbg; Post-Menopausal Women; African American; Hispanic; Type 2 Diabetes
Related Studies: 238
Birthweight, mediating biomarkers and the development of type 2 diabetes later in life: a prospective study of multi-ethnic women
AIMS/HYPOTHESIS: The aim of this work was to investigate the prospective relationship between low birthweight (LBW) and type 2 diabetes risk later in life and the mediation effects of type 2 diabetes biomarkers linking LBW to type 2 diabetes risk. METHODS: We measured baseline plasma concentrations of various type 2 diabetes biomarkers in 1,259 incident type 2 diabetes cases and 1,790 controls in the Women's Health Initiative-Observational Study. Self-report birthweights of the participants were...
Keywords: Birth Weight; Type 2 Diabetes; Insulin Resistance; Telomere; Inflammation; Endothelial Dysfunction; Sex Steroid
Relations of sex hormone levels to leukocyte telomere length in black, hispanic, and asian/Pacific Islander postmenopausal women
BACKGROUND: Sex hormones may play important roles in sex-specific biological aging. We specifically examined the associations between circulating concentrations of sex hormones and leukocyte telomere length (TL). METHODS: We conducted a cross-sectional study of 1124 black, 444 Hispanic, and 289 Asian/Pacific Islander women in the Women's Health Initiative Observational Cohort. Concentrations of estradiol and testosterone were measured using electrochemiluminescence immunoassays. TL was measured ...
Keywords: Aging; Estradiol; Sex Steroid Hormones; Telomere Length; Testosterone
Circulating SHBG (Sex Hormone-Binding Globulin) and risk of ischemic stroke: Findings from the WHI
Abstract Background and Purpose- Circulating levels of SHBG (sex hormone-binding globulin) have been inversely linked to obesity, diabetes mellitus, and other cardiometabolic disorders. It remains uncertain whether low SHBG is prospectively predictive of stroke risk, particularly in women. We investigated whether SHBG is associated with risk of incident ischemic stroke (IS) among women in the WHI (Women's Health Initiative). Methods- From an observational cohort of 161 808 postmenopausal women e...
Keywords: Ischemic Stroke; Sex Hormone Binding Globulin; Sex Hormones; Prevention; Sex Differences
Plant-based dietary index, diabetes incidence and mediating effects of biomarkers in postmenopausal women
Keywords: Biomarkers; Type 2 Diabetes; Plant-Based Diet Index; Postmenopausal Women; Dietary Patterns
Related Studies: 238
