AS129 - Association of diabetes and insulin-like growth factor-I (IGF-I) with risks of colorectal, breast, and endometrial cancer
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| NameAS129 subject selection 1-30-02 summary.pdf | Description |
Related Papers
Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women
Obesity is a risk factor for colorectal cancer, and hyperinsulinemia, a common condition in obese patients, may underlie this relationship. Insulin, in addition to its metabolic effects, has promitotic and antiapoptotic activity that may be tumorigenic. Insulin-like growth factor (IGF)-I, a related hormone, shares sequence homology with insulin, and has even stronger mitogenic effects. However, few prospective colorectal cancer studies directly measured fasting insulin, and none evaluated free I...
Keywords: Insulin-Like Growth Factor-I (Igf-I); Igf Binding Protein-3 (Igfbp-3); Estradiol; Colorectal Cancer; Case-Cohort Design.
Related Studies: 129
Evaluation of differences in the association of insulin/IGF axis components with breast cancer risk by estrogen receptor status in a case-cohort investigation: a formal analysis
Keywords: Insulin; Insulin-Like Growth Factor (Igf-I; Igf-Bp3); Er Positive And Er Negative Breast Cancer; Case-Cohort Design
Related Studies: 129
Interaction of insulin-like growth factor-I and insulin resistance–related genetic variants with obesity and lifestyle factors on postmenopausal breast cancer risk
PURPOSE: Genetic variants and traits in metabolic signaling pathways may interact with obesity, physical activity, and exogenous estrogen (E), influencing postmenopausal breast cancer risk, but these inter-related pathways are incompletely understood. METHODS: We used 75 single-nucleotide polymorphisms (SNPs) in genes related to insulin-like growth factor-I (IGF-I)/insulin resistance (IR) traits and signaling pathways, and data from 1003 postmenopausal women in Women's Health Initiative Observat...
Keywords: Breast Cancer; Exogenous Estrogen; Insulin-Like Growth Factor-I/Insulin Resistance-Related Genetic Variant; Obesity; Physical Activity; Postmenopausal Women
A prospective study of soluble receptor for advanced glycation end-products and colorectal cancer risk in postmenopausal women
OBJECTIVES: Receptor for advanced glycation end products (RAGE) expressed on adipocytes and immune cells can bind to ligand Ne-(carboxymethyl)-lysine (CML) and trigger dysregulation of adipokines and chronic inflammation. Soluble RAGE (sRAGE) mitigates the detrimental effect of RAGE. We examined the associations between circulating levels of CML-AGE and sRAGE and colorectal cancer (CRC). METHODS: In a case-cohort study of the Women's Health Initiative Study, blood levels of CML-AGE and sRAGE wer...
Keywords: Advanced Glycation End-Products; Body Weight; Colorectal Cancer; Epidemiology; N(E)-(Carboxymethyl)-Lysine; Obesity; Pattern Recognition Receptors; Receptor For Advanced Glycosylation End-Products; Srage
Breast cancer risk in metabolically healthy but overweight postmenopausal women
Adiposity is an established risk factor for postmenopausal breast cancer. Recent data suggest that high insulin levels in overweight women may play a major role in this relationship, due to insulin's mitogenic/antiapoptotic activity. However, whether overweight women who are metabolically healthy (i.e., normal insulin sensitivity) have elevated risk of breast cancer is unknown. We investigated whether overweight women with normal insulin sensitivity [i.e., homeostasis model assessment of insulin...
Keywords: Obesity; Insulin Resistance; Metabolic Syndrome; Breast Cancer; Colorectal Cancer; Healthy Obese
Related Studies: 129
Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk
Genetic variants and traits in metabolic signaling pathways may interact with lifestyle factors such as obesity, physical activity, and exogenous estrogen (E), influencing postmenopausal colorectal cancer (CRC) risk, but these interrelated pathways are not fully understood. In this case-cohort study, we examined 33 single-nucleotide polymorphisms (SNPs) in genes related to insulin-like growth factor-I (IGF-I)/ insulin resistance (IR) traits and signaling pathways, using data from 704 postmenopau...
Keywords: Colorectal Cancer Risk; Insulin Resistance; Glucose Metabolism-Relevant Single-Nucleotide Polymorphism; Obesity; Postmenopausal Women
A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer
Obesity is a major risk factor for endometrial cancer, a relationship thought to be largely explained by the prevalence of high estrogen levels in obese women. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed whether insulin and/or insulin-like growth factor-I (IGF-I), a related hormone, are associated with endometrial cancer while accounting for estrogen levels. We therefore conducted a case-cohort study of incident ...
Keywords: Insulin-Like Growth Factor-I (Igf-I); Igf Binding Protein-3 (Igfbp-3) Estradiol; Endometrial Cancer; Hormone Replacement Therapy; Case-Cohort Design.
Related Studies: 129
Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
The positive association between obesity and postmenopausal breast cancer has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is synthesized in adipose tissue. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level.W...
Keywords: Insulin-Like Growth Factor-I (Igf-I); Igf Binding Protein-3 (Igfbp-3) Estradiol; Breast Cancer; Hormone Replacement Therapy; Case-Cohort Design.
Related Studies: 129
Circulating adipokines and inflammatory markers and postmenopausal breast cancer risk
Adipokines and inflammation may provide a mechanistic link between obesity and postmenopausal breast cancer, yet epidemiologic data on their associations with breast cancer risk are limited.In a case-cohort analysis nested within the Women's Health Initiative Observational Study, a prospective cohort of postmenopausal women, baseline plasma samples from 875 incident breast cancer case patients and 839 subcohort participants were tested for levels of seven adipokines, namely leptin, adiponectin, ...
Keywords: Breast Cancer; Adipokine; Insulin; Obesity
Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption and breast cancer
BACKGROUND: Increased exposure to endogenous estrogen and/or insulin may partly explain the relationship of obesity, physical inactivity, and alcohol consumption and postmenopausal breast cancer. However, these potential mediating effects have not been formally quantified in a survival analysis setting. METHODS: We combined data from two case-cohort studies based in the Women's Health Initiative-Observational Study with serum estradiol levels, one of which also had insulin levels. A total of 1,6...
Keywords: Lifestyle; Estrogens; Breast Cancer; Postmenopause; Mediating Effects
Associations of serum insulin-like growth factor-I and insulin-like growth factor-binding protein 3 levels with biomarker-calibrated protein, dairy product and milk intake in the Women's Health Initiative
It is well established that protein-energy malnutrition decreases serum insulin-like growth factor (IGF)-I levels, and supplementation of 30 g of whey protein daily has been shown to increase serum IGF-I levels by 8 % after 2 years in a clinical trial. Cohort studies provide the opportunity to assess associations between dietary protein intake and IGF axis protein levels under more typical eating conditions. In the present study, we assessed the associations of circulating IGF axis protein level...
Keywords: Protein; Biomarker Calibration; Igf-I; Igfbp-3; Free Igf
Related Studies: 129
Testing the proportionality of the hazards in case-cohort studies
Case-cohort studies have become common in epidemiological studies of rare disease, with Cox regression models the principal method used in their analysis. However, no appropriate procedures to assess the assumption of proportional hazards of case-cohort Cox models have been proposed.We extended the correlation test based on Schoenfeld residuals, an approach used to evaluate the proportionality of hazards in standard Cox models. Specifically, pseudolikelihood functions were used to define ''case-...
Keywords: Proportionality; Schoenfeld Residual; Case-Cohort Study; Cox Proportional Hazards Model; Pseudo-Likelihood Function
Related Studies: 129
Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C-reactive protein, fasting insulin, and estradiol
Background: Mechanisms underlying the adiposity-cancer relationship are incompletely understood. We quantified the mediating roles of C-reactive protein (CRP), leptin, fasting insulin, and estradiol in the effect of adiposity on estrogen receptor (ER)-positive breast, endometrial, and colorectal cancer risk in postmenopausal women. Methods: We used a case-cohort study within the Women's Health Initiative Observational Study, analyzed as a cumulative sampling case-control study. The study include...
Keywords: Adiposity; Causal Mediation Analysis; Inflammation; C-Reactive Protein; Insulin; Estrogens; Estradiol; Breast Cancer; Endometrial Cancer; Colorectal Cancer
