AS476 - APOL1, sickle cell trait and risk of chronic kidney disease in African Americans
Investigator Names and Contact Information
Nora Franceschini (noraf@unc.edu)
Introduction/Intent
Pilot study of African-specific Variants and chronic kidney disease
Aim 1: Leveraging the existing, but untapped biorepository resource of the largest population-based longitudinal data set of African Americans in the U.S., perform baseline serum creatinine measurements in 3,826 AA women from the Women's Health Initiative, to allow an unprecedented examination of the risk and progression of CKD and ESRD associated with APOL1 and SCT individually in African Americans, while accounting for traditional risk factors and the competing risk of early death.
Aim 2: Assess whether the effects of APOL1 and SCT variants on the risk of CKD in African Americans are modified by other known genetic risk factors for CKD using (a) trans-ethnic genome wide association study (GWAS) derived risk scores.; (b) novel genome-wide analytic approaches and local ancestry-based admixture mapping.
Results/ Findings
For a complete, up-to-date list of WHI papers related to this ancillary study, please use the searchable Papers section of this website.
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
Name | Description |
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| NameAS476SelectionSummary_20180322.docx | Description |
| NameAS476SelectionSummary_20161116.docx | Description |
