BA9 - Biochemical antecedents of fracture in minority women
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| NameBA09_Case_control_selection_05092007.doc | Description |
Related Papers
Relation of dietary carbohydrates intake to circulating sex hormone-binding globulin levels in postmenopausal women
BACKGROUND: Low circulating levels of sex hormone-binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone-dependent cancers, although the relation between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies. METHODS: Among postmenopausal women with available SHBG measurements at baseline (n = 11,159) in the Women's Health Initiative, we conducted a comprehensive assessmen...
Keywords: Dietary Carbohydrates; Glycemic Index; Glycemic Load; Sex Hormone Binding Globulin (Shbg); Type 2 Diabetes
Higher biomarker-calibrated protein intake is not associated with impaired renal function in postmenopausal women
With aging, renal function tends to decline, as evidenced by reduced glomerular filtration rate. High-protein intake may further stress the kidneys by causing sustained hyperfiltration. To investigate whether dietary protein is associated with impaired renal function, we used data from 2 nested case-control studies within the Women's Health Initiative Observational Study (n = 2419). We estimated protein intake using a FFQ and estimated glomerular filtration rate (eGFR) from cystatin C. To accoun...
Keywords: Renal Function; Protein; Calibration; Aging
Serum 25 hydroxyvitamin (OH)D and clinical fracture risk in a multiethnic cohort of women: The Women's Health Initiative (WHI)
Low 25-hydroxyvitamin D [25(OH)D] levels have been linked to hip fracture in white women. To study the association of 25(OH)D with risk of fracture in multiethnic women, we performed a nested case-control study within the prospective Women's Health Initiative (WHI) Observational Study. Incident fractures were identified in 381 black, 192 Hispanic, 113 Asian, and 46 Native American women over an average of 8.6 years. A random sample of 400 white women who fractured was chosen. One control individ...
Keywords: Osteoporosis; Fractures; Minority Women; Race/Ethnicity; Vitamin D; Parathyroid Hormone
Related Studies: BA9
Renal function and nonvertebral fracture risk in multiethnic women: the Women's Health Initiative (WHI)
To examine the association between renal function and fracture in multiethnic women, we studied postmenopausal women enrolled in the Women's Health Initiative. Postmenopausal White women with mild renal dysfunction were at increased risk of nonvertebral fracture; this association was at least partially explained by effects of renal dysfunction on chronic inflammation. Reduced renal function appeared to increase fracture risk among Black women, but there was little evidence to support this associ...
Keywords: Osteoporosis; Fractures; Minority Women; Race/Ethnicity; Renal Function; Cystatin C
Related Studies: BA9
Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women
Circulating concentrations of sex hormone-binding globulin (SHBG) have been associated with cardiovascular diseases, type 2 diabetes, metabolic syndrome, and hormone-dependent cancers; however, correlates of SHBG concentrations are not well understood.We comprehensively investigated correlates of SHBG concentrations among 13 547 women who participated in the Women's Health Initiative and who had SHBG measurements. We estimated study- and ethnicity-specific associations of age, reproductive histo...
Keywords: Plasma Sex Hormone Binding Globulin (Shbg); Dietary Factors
Sex steroid hormones and fracture in a multi-ethnic cohort of women: The Women's Health Initiative Study (WHI)
CONTEXT: We hypothesize that endogenous sex steroids are associated with fracture risk independent of race/ethnicity. DESIGN AND SETTING: We performed a nested case-control study within the prospective Women's Health Initiative Observational Study (WHI-OS). Incident non-spine fractures were identified in 381 Black, 192 Hispanic, 112 Asian, and 46 Native American women over an average of 8.6 years. A random sample of 400 White women who experienced an incident fracture was chosen. One control was...
Keywords: Osteoporosis; Fractures; Minority Women; Race/Ethnicity; Cytokines; Sex Steroid Hormones; Bone Turnover
Related Studies: BA9
Circulating SHBG (Sex Hormone-Binding Globulin) and risk of ischemic stroke: Findings from the WHI
Abstract Background and Purpose- Circulating levels of SHBG (sex hormone-binding globulin) have been inversely linked to obesity, diabetes mellitus, and other cardiometabolic disorders. It remains uncertain whether low SHBG is prospectively predictive of stroke risk, particularly in women. We investigated whether SHBG is associated with risk of incident ischemic stroke (IS) among women in the WHI (Women's Health Initiative). Methods- From an observational cohort of 161 808 postmenopausal women e...
Keywords: Ischemic Stroke; Sex Hormone Binding Globulin; Sex Hormones; Prevention; Sex Differences
Sex hormones, sex hormones binding globulin (SHBG), and risk of ischemic stroke in men and women in WHI and TOPMed Stroke
Keywords: Stroke; Sex Hormone Binding Globulin; Mendelian Randomization; Single Nucleotide Polymorphisms; Ischemic Stroke
