AS262 - Women's Health Initiative memory study of younger women (WHIMS-Y)
Investigator Names and Contact Information
Stephen Rapp (srapp@wakehealth.edu)
Introduction/Intent
WHIMS-Y (WHI Memory Study of Younger Women; WHI Study #AS262) 2009 – 2016
N~1,000
The Women's Health Initiative Memory Study of Younger Women (WHIMS-Y) aims to assess the long-term impact of random assignment to postmenopausal hormone therapy among women who were aged 50-54 at the time of randomization into the WHI hormone trials. Secondary objectives relate to the consistency of any treatment effects across unopposed or opposed therapy and whether there exists evidence of graded relationships between cognitive effects and age of administration, years from menopause, and baseline risk factors for cognitive impairment. Assessment procedures identical to those in WHIMS-ECHO were used with central adjudication of impairment.
Related Papers
Long-term effects of depression on cognitive function in women aged 50-54 years: the Women’s Health Initiative Memory Study of Younger Women (WHIMS-Y)
Keywords: Depression; Cognitive Impairment; Younger Women
Related Studies: 262
The effect of menopausal symptom severity on cognitive change over time
Keywords: Hormone Therapy; Menopause Symptoms; Cognitive Decline; Lifestyle
Related Studies: 262
Accelerometery-measured physical activity, sedentary behavior, and cognitive function in older adults: The Women’s Health Initiative- Objective Physical Activity and Cardiovascular Health in Older Women (OPACH) Study
Keywords: Physical Activity; Accelerometry; Exercise; Cognitive Function; Memory
Independent, but not synergistic, associations of APOE4 and systemic inflammation on cognitive decline: findings from the Women’s Health Initiative
Keywords: Inflammation; Fasting Glucose; Apoe; Cognitive Decline; Dementia Incidence
Related Studies: 262
Long-term effects on cognitive trajectories of postmenopausal hormone therapy in two age groups
BACKGROUND: Postmenopausal hormone therapy may have long-term effects on cognitive function depending on women's age. METHODS: Postintervention follow-up was conducted with annual cognitive assessments of two randomized controlled clinical trial cohorts, beginning an average of 6-7 years after study medications were terminated: 1,376 women who had enrolled in the Women's Health Initiative when aged 50-54 years and 2,880 who had enrolled when aged 65-79 years. Women had been randomly assigned to ...
Keywords: Hormone Therapy; Cognitive Decline; Aging; Risk Factors For Cognitive Decline
Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50-55 years
Postmenopausal hormone therapy with conjugated equine estrogens (CEEs) may adversely affect older women’s cognitive function. It is not known whether this extends to younger women.To test whether prescribing CEE-based hormone therapy to postmenopausal women aged 50 to 55 years has longer-term effects on cognitive function.Trained, masked staff assessed participants with an annual telephone-administered cognitive battery that included measures of global and domain-specific cognitive functions. Co...
Keywords: Hormone Therapy; Cognition
Related Studies: 262
The rationale, design, and baseline characteristics of the Women's Health Initiative Memory Study of Younger Women (WHIMS-Y)
The Women's Health Initiative Memory Study-Younger (WHIMS-Y) was designed to assess the effect of prior random assignment to hormone therapy (HT) (conjugated equine estrogen (CEE) alone or CEE plus medroxyprogesterone acetate (MPA)) on global cognitive function in younger middle-aged women relative to placebo. WHIMS-Y was an ancillary study to the Women's Health Initiative (WHI) HT trial and enrolled 1361 women who were aged 50-55 years and postmenopausal at WHI enrollment. WHIMS-Y will examine ...
Keywords: Cognitive Function; Study Design
Related Studies: 262
Artificially sweetened beverages, stroke, coronary heart disease, and all-cause mortality in the Women's Health Initiative
Background and Purpose- We examine the association between self-reported consumption of artificially sweetened beverages (ASB) and stroke and its subtypes, coronary heart disease, and all-cause mortality in a cohort of postmenopausal US women. Methods- The analytic cohort included 81 714 women from the Women's Health Initiative Observational Study, a multicenter longitudinal study of the health of 93 676 postmenopausal women of ages 50 to 79 years at baseline who enrolled in 1993 to 1998. This p...
Keywords: Dementia; Soft Drinks; Diet Soda; Artificial And Sweetened Beverages; Stroke; Sugar
Plasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory St...
Keywords: Inflammation; Dementia; Alzheimer’S Disease; Proteomics; Diet
