AS244 - Women's Health Initiative memory study epidemiology of cognitive health (WHIMS-ECHO)
Investigator Names and Contact Information
Stephen Rapp (srapp@wakehealth.edu)
Introduction/Intent
WHI Epidemiology of Cognitive Health Outcomes (ECHO; WHI Study #AS244, WHIMS ECHO)
2008 – 2021
N~2,900
Women who were previously enrolled in the WHIMS Extension were recruited for WHIMS ECHO beginning in 2008. Instead of face-to-face evaluation, participants underwent an annual centralized, validated cognitive telephone interview for tracking changes in cognitive status (Rapp et al., 2012). The interview is comprised of a neuropsychological battery including a global cognitive screener (modified Telephone Interview for Cognitive Status, known as the TICSm) and additional neuropsychological tests. A score <30 triggers the collection of the Dementia Questionnaire from the proxy. As in WHIMS, all information is submitted to the central adjudication panel for classification (Dementia, MCI, No Impairment).
Related Papers
Clonal Hematopoiesis of Indeterminate Potential and the risk of mild cognitive impairment or probable dementia in the Women’s Health Initiative Memory Study
Keywords: Mild Cognitive Impairment; Probable Dementia; Risk Factor; Clonal Hematopoiesis Of Indeterminate Potential
Accelerometery-measured physical activity, sedentary behavior, and cognitive function in older adults: The Women’s Health Initiative- Objective Physical Activity and Cardiovascular Health in Older Women (OPACH) Study
Keywords: Physical Activity; Accelerometry; Exercise; Cognitive Function; Memory
Determinants of latent profiles of home environmental modifications use in older women
Keywords: Aging; Home Environmental Modifications; Functional Independence; Disability; Latent Class Analysis
Related Studies: 244
Concurrent and longitudinal relationships between cognitive activity, cognitive performance, and brain volume in older adult women
We investigated (a) cross-sectional associations between cognitive activity, cognitive performance, and MRI measures and (b) longitudinal associations between cognitive activity and change in cognitive performance, using structural equation modeling (SEM).Women's Health Initiative Memory Study (WHIMS) Extension participants who continued annual neuropsychological assessments by telephone and completed a concurrent questionnaire of cognitive activities and MRI scans were included (mean age = 81.4...
Keywords: Activity Engagement; Cognition; Mri; Aging; Structural Equation Modeling
Related Studies: 244
Association of visual impairment with risk of incident dementia in a Women's Health Initiative population
Importance: Dementia affects a large and growing population of older adults. Although past studies suggest an association between vision and cognitive impairment, there are limited data regarding longitudinal associations of vision with dementia. Objective: To evaluate associations between visual impairment and risk of cognitive impairment. Design, setting, and participants: A secondary analysis of a prospective longitudinal cohort study compared the likelihood of incident dementia or mild cogni...
Keywords: Visual Impairment; Vision; Cognitive Function; Dementia; Alzheimer’S Disease
Association of global cognitive function with psychological distress and adherence to public health recommendations during the COVID-19 Pandemic: The Women’s Health Initiative
Background: The association of cognitive function with symptoms of psychological distress during the coronavirus 2019 (COVID-19) pandemic or adherence to COVID-19 protective health behaviors is not well understood. Methods: We examined 2,890 older women from the Women's Health Initiative cohort. Pre-pandemic (i.e., within 12 months prior to pandemic onset) and peri-pandemic global cognitive function scores were assessed with the modified Telephone Interview for Cognitive Status (TICS-m). Anxiety...
Keywords: Covid-19; Cognitive Function; Psychological Distress; Depression; Anxiety; Stress; Older Women
Driving with mild cognitive impairment or dementia: cognitive test performance and proxy report of daily life function in older women
To investigate associations between proxy report of cognitive and functional limitations and cognitive performance and current or former driving status in older women with mild cognitive impairment (MCI) and all-cause dementia.Cross-sectional data analysis of retrospectively identified older women with adjudicated MCI and all-cause dementia in the Women's Health Initiative Memory Study-Epidemiology of Cognitive Health Outcomes (WHIMS-ECHO).Academic medical center.Women (mean age ± standard devia...
Keywords: Driving; Dementia; Cognitive Impairment; Proxy
Related Studies: 244
Cognitive resilience among APOE e4 carriers in the oldest old
OBJECTIVE: Relatively few APOE e4+ carriers survive to old age (age 80+) without cognitive impairment (CI), thus little is known about distinguishing characteristics of resilient APOE e4+ carriers. Herein we describe the sociodemographic characteristics of a large sample of resilient APOE e4+ women from the Women's Health Initiative Memory Study (WHIMS) and compare them to non-carriers and APOE e4+ women who developed CI before age 80. METHODS: Women were recruited for clinical trials evaluating...
Keywords: Apoe; Cognitive Decline; Cognitive Resilience; Mild Cognitive Impairment; Dementia; Alzheimer’S Disease
Adherence to MIND Diet, genetic susceptibility, and incident dementia in three US cohorts
Adherence to Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) may lower the risk of dementia by impacting immunity and cholesterol, which are pathways also implicated by genome-wide association studies of Alzheimer's Dementia (AD). We examined whether adherence to the MIND diet could modify the association of genetic risk for AD with incident dementia. We used three ongoing US cohorts: Chicago Health and Aging Project (CHAP, n = 2449), Rush Memory and Aging Project (MAP, n...
Keywords: Mind; Cognitive Decline; Clinical Trial; Genetics; Alzheimer’S Disease
Adverse pregnancy outcomes and the risk of cognitive impairment: a prospective analysis of the Women’s Health Initiative Memory Study
Keywords: Dementia; Cognitive Impairment; Pregnancy Outcome; Hypertensive Disorders Of Pregnancy; Gestational Diabetes Mellitus; The Women'S Health Initiative.
Related Studies: 244
Artificially sweetened beverages, stroke, coronary heart disease, and all-cause mortality in the Women's Health Initiative
Background and Purpose- We examine the association between self-reported consumption of artificially sweetened beverages (ASB) and stroke and its subtypes, coronary heart disease, and all-cause mortality in a cohort of postmenopausal US women. Methods- The analytic cohort included 81 714 women from the Women's Health Initiative Observational Study, a multicenter longitudinal study of the health of 93 676 postmenopausal women of ages 50 to 79 years at baseline who enrolled in 1993 to 1998. This p...
Keywords: Dementia; Soft Drinks; Diet Soda; Artificial And Sweetened Beverages; Stroke; Sugar
Association between purpose in life, personal growth, and risk of mild cognitive impairment (MCI) and dementia
Keywords: Purpose In Life; Personal Growth; Mild Cognitive Impairment; Dementia; Mediation Analysis; Well-Being
Related Studies: 244
Plasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory St...
Keywords: Inflammation; Dementia; Alzheimer’S Disease; Proteomics; Diet
Plasma oxysterols are associated with serum lipids and dementia risk in older women
Introduction: Apolipoprotein E4 (APOE4) carriers' tendency toward hypercholesterolemia may contribute to Alzheimer's disease (AD) risk through oxysterols, which traverse the blood-brain barrier. Methods: Relationships between baseline plasma oxysterols, APOE status, serum lipids, and cognitive impairment risk were examined in 328 postmenopausal women from the Women's Health Initiative Memory Study. Women were followed for 25 years or until incident dementia or cognitive impairment. Results: Leve...
Keywords: Oxysterols; Blood Lipids; Apoe Gene; Dementia; Alzheimer’S Disease
Accelerometer-measured physical activity and sitting with incident mild cognitive impairment or probable dementia among older women
Introduction: Physical activity (PA) is prospectively inversely associated with dementia risk, but few studies examined accelerometer measures of PA and sitting with rigorously-adjudicated mild cognitive impairment (MCI) and dementia risk.
Methods: We examined the associations of accelerometer measures (PA and sitting) with incident MCI/probable dementia in the Women's Health Initiative (n = 1277; mean age = 82 ± 6 years) RESULTS: Over a median follow-up of 4.2 years, 267 MCI/probable dementia c...
Keywords: Physical Activity; Sedentary Behavior; Cognitive Impairment; Dementia; Epidemiology
Association of social support with mild cognitive impairment and dementia among older women: Women’s Health Initiative Memory Study
Background: Social support may be a modifiable risk factor for cognitive impairment. However, few long-term, large prospective studies have examined associations of various forms of social support with incident mild cognitive impairment (MCI) and dementia.Objective: To examine associations of perceived social support with incident MCI and dementia among community-dwelling older women.
Methods: This prospective cohort study included 6,670 women from the Women's Health Initiative Memory Study who ...
Keywords: Social Support; Mild Cognitive Impairment; Dementia; Mediation Analysis; Inverse Probability Weighting
Association between blood pressure levels and cognitive impairment in older women: a prospective analysis of the Women's Health Initiative Memory Study
Background: Whether blood pressure (BP), and at what level of controlled BP, reduces risk of cognitive impairment remains uncertain. We investigated the association of BP and hypertension treatment status with mild cognitive impairment and dementia in older women. Methods: We prospectively analysed a sample of 7207 community-dwelling women aged 65-79 years participating in the Women's Health Initiative Memory Study (WHIMS). Participants were recruited between May 28, 1996, and Dec 13, 1999, at 3...
Keywords: Blood Pressure; Cognitive Function; Dementia
The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women’s Health Initiative Memory Study (WHIMS)
INTRODUCTION: The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. METHODS: Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia c...
Keywords: Inflammatory Diet; Global Cognitive Function; Dementia; Older Women
Long-term effects on cognitive trajectories of postmenopausal hormone therapy in two age groups
BACKGROUND: Postmenopausal hormone therapy may have long-term effects on cognitive function depending on women's age. METHODS: Postintervention follow-up was conducted with annual cognitive assessments of two randomized controlled clinical trial cohorts, beginning an average of 6-7 years after study medications were terminated: 1,376 women who had enrolled in the Women's Health Initiative when aged 50-54 years and 2,880 who had enrolled when aged 65-79 years. Women had been randomly assigned to ...
Keywords: Hormone Therapy; Cognitive Decline; Aging; Risk Factors For Cognitive Decline
Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants
OBJECTIVES: As people age and the incidence of dementia increases, studies of cognitive function continue to be of importance. Ascertaining cognitive data through different mechanisms is necessary to address missing data concerns. METHODS: The Dementia Questionnaire (DQ), which utilizes proxy-based assessments, is a potential tool to determine cognitive status in participants no longer being followed per traditional study protocol. The DQ is currently being used in the Supplemental Case Ascertai...
Keywords: Attrition; Cognitive Impairment; Dementia; Missing Data
Patterns of home environmental modification use and functional health: The Women's Health Initiative
Background: We examined common patterns of home environmental modification (HEM) use and associated major (including disability-, cardiovascular-, and cancer-related) health conditions and events among older women. Methods: Women, aged 78.6 ± 6.3 years (n = 71,257), self-reported utilization of nine types of HEMs (hand rails, grab bars, ramps, nonslip surfaces, tacking carpets/rugs, decreasing clutter, increasing lighting, raised sink/counter heights, other). Concurrent history of major health ...
Keywords: Aging; Home Environmental Modifications; Functional Independence; Disability; Latent Class Analysis
Related Studies: 244
Patterns of home environmental modification use and functional health: The Women’s Health Initiative
Abstract BACKGROUND: We examined common patterns of home environmental modification (HEM) use and associated major (including disability-, cardiovascular-, and cancer-related) health conditions and events among older women. METHODS: Women, age 78.6±6.3 years (n=71,257), self-reported utilization of 9 types of HEMs (hand rails, grab bars, ramps, non-slip surfaces, tacking carpets/rugs, decreasing clutter, increasing lighting, raised sink/counter heights, other). Concurrent history of major health...
Keywords: Aging; Home Environmental Modifications; Functional Independence; Disability; Longitudinal; Latent Class Analysis
Related Studies: 244
