AS103 - Effects of hormone replacement therapy on cognitive aging (WHISCA)
Investigator Names and Contact Information
Sally Shumaker (sshumake@wakehealth.edu)
Introduction/Intent
WHI Study of Cognitive Aging (WHISCA; WHI Study #AS103)
1999 - 2010
N~2,302
The WHI Study of Cognitive Aging (WHISCA) enrolled 2,302 WHIMS participants aged 66 to 84 years on average 3 years after WHI randomization and investigated the efficacy of postmenopausal hormone therapy on age related changes in specific cognitive functions in non-demented women at 14 of the 39 WHIMS sites. WHISCA provides more comprehensive annual assessments of cognitive function and mood. Annual follow-up of the WHISCA women continued after the termination of the WHI trials until 2010.
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The Women’s Health Initiative Study of Cognitive Aging (WHISCA): A randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
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Keywords: Tamoxifen; Raloxifene; Cognition
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Keywords: Cognitive Decline; Dementia; Folate Intake; Folic Acid Supplementation; Hormone Replacement Therapy
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Keywords: Cognition; Obesity; Central Adiposity; Weight Change
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Keywords: Social Environment; Social Support; Social Integration; Aging; Cognition; Neuropsychology; Structural Mri; Brain Volumes
?-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA
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Keywords: Ht; Fatty Acids; Omega-3 Index; Dha; Epa; Acids; Omega-3; Eicosapentaenoic Acid; Docosahexaenoic Acids; Cognition; Aging; Ht; Fatty Acids; Omega-3 Index; Dha; Epa
Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women’s Health Initiative Study of Cognitive Aging Extension
To determine whether small decrements in global cognitive function that conjugated equine estrogen (CEE) therapies have been shown to produce in older women persist after cessation and extend to specific cognitive domains.Randomized controlled clinical trial.Fourteen clinical centers of the Women's Health Initiative.Two thousand three hundred four women aged 65 to 80 free of probable dementia at enrollment.CEE 0.625 mg/d with or without medroxyprogesterone acetate (MPA, 10 mg/d) and matching pla...
Keywords: Changes In Cognitive Specific Function
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Application of hidden Markov models to longitudinal measures of cognition collected by the Women’s Health Initiative Study of Cognitive Aging
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Depressive symptoms and longitudinal declines in cognition: Women’s Health Initiative Study of Cognitive Aging
Elevated depressive symptoms (DS) are associated with incident mild cognitive impairment and probable dementia in postmenopausal women. We examined the association of elevated DS with domain-specific cognitive changes and the moderating role of cardiovascular risk factor severity and cardiovascular disease (CVD). A total of 2221 elderly women who participated in the Women's Health Initiative Study of Cognitive Aging were separated into those with (N = 204) and without (N = 2017) elevated DS. The...
Keywords: Vascular Risk Factors And Disease; Depression; Cognitive Domains; Cognitive Decline; Interactions.
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Omega-3 fatty acid biomarkers and depressive symptoms
We sought to determine the relationship between the omega-3 fatty acid content of red blood cell membranes (RBC), in particular docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and baseline and new-onset depressive symptoms in post-menopausal women. We secondarily sought to characterize the association between dietary omega-3 fatty acid intake and depressive symptomatology.Study participants included 7086 members of the Women's Health Initiative Memory Study (aged 63-81 years) who had...
Keywords: Omega-3 Fatty Acids; Depression; Hormone Therapy
Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy
Different menopausal hormone therapies may have varied effects on specific cognitive functions. We previously reported that conjugated equine estrogens (CEE) with medroxyprogesterone acetate had a negative impact on verbal memory but tended to impact figural memory positively over time in older postmenopausal women.The objective of the study was to determine the effects of unopposed CEE on changes in domain-specific cognitive function and affect in older postmenopausal women with prior hysterect...
Keywords: Estrogen; Ht; Cee; Mpa; Cognition; Memory; Mood; Affect
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Plasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory St...
Keywords: Inflammation; Dementia; Alzheimer’S Disease; Proteomics; Diet
