AS103 - Effects of hormone replacement therapy on cognitive aging (WHISCA)
Investigator Names and Contact Information
Sally Shumaker (sshumake@wakehealth.edu)
Introduction/Intent
WHI Study of Cognitive Aging (WHISCA; WHI Study #AS103)
1999 - 2010
N~2,302
The WHI Study of Cognitive Aging (WHISCA) enrolled 2,302 WHIMS participants aged 66 to 84 years on average 3 years after WHI randomization and investigated the efficacy of postmenopausal hormone therapy on age related changes in specific cognitive functions in non-demented women at 14 of the 39 WHIMS sites. WHISCA provides more comprehensive annual assessments of cognitive function and mood. Annual follow-up of the WHISCA women continued after the termination of the WHI trials until 2010.
Related Papers
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The Women’s Health Initiative Study of Cognitive Aging (WHISCA): A randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
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Keywords: Ht; Fatty Acids; Omega-3 Index; Dha; Epa; Acids; Omega-3; Eicosapentaenoic Acid; Docosahexaenoic Acids; Cognition; Aging; Ht; Fatty Acids; Omega-3 Index; Dha; Epa
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Keywords: Diabetes And Cognition
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The influence of social support on cognitive health in older women: a Women's Health Initiative Study
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Keywords: Social Environment; Social Support; Social Integration; Aging; Cognition; Neuropsychology; Structural Mri; Brain Volumes
Application of hidden Markov models to longitudinal measures of cognition collected by the Women’s Health Initiative Study of Cognitive Aging
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Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women’s Health Initiative Study of Cognitive Aging Extension
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Keywords: Changes In Cognitive Specific Function
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Calcium and vitamin D supplementation and cognitive impairment in the Women's Health Initiative
Impairments in physical performance increase sharply with age. Low serum 25-hydroxyvitamin D (25-OHD) levels may be a modifiable risk factor for physical performance decline.Five hundred thirty-two participants in the Women's Health Initiative Clinical Trial (WHI CT) were among a 25% randomly selected subsample of women who participated in performance-based measures of physical performance at baseline, year 1, year 3, and year 6. A physical performance summary score was derived from three tests:...
Plasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory St...
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Depressive symptoms and longitudinal declines in cognition: Women’s Health Initiative Study of Cognitive Aging
Elevated depressive symptoms (DS) are associated with incident mild cognitive impairment and probable dementia in postmenopausal women. We examined the association of elevated DS with domain-specific cognitive changes and the moderating role of cardiovascular risk factor severity and cardiovascular disease (CVD). A total of 2221 elderly women who participated in the Women's Health Initiative Study of Cognitive Aging were separated into those with (N = 204) and without (N = 2017) elevated DS. The...
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Keywords: Omega-3 Fatty Acids; Depression; Hormone Therapy
Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy
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Keywords: Estrogen; Ht; Cee; Mpa; Cognition; Memory; Mood; Affect
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