AS233 - WHIMS (AS39) extension (See AS244)
Investigator Names and Contact Information
Sally Shumaker (sshumake@wakehealth.edu)
Introduction/Intent
Supplemental Case Ascertainment Protocol (SCAP; Subset of AS233, WHIMS Extension)
2005 - Present
N~1,025
SCAP was instituted in 2005 to identify cases of Probable Dementia (PD) and Mild Cognitive Impairment (MCI), in the deceased and proxy-dependent participants. SCAP includes the Dementia Questionnaire (DQ), a standardized, validated instrument used to reliably classify dementia in deceased persons. It has demonstrated sensitivity and specificity. The DQ consists of 48 items assessing memory and other cognitive functions, language, daily functioning, insight, and other medical and psychiatric difficulties. The DQ is a semi-structured interview that was administered by telephone to informants previously selected by the participant, who are knowledgeable about the participant's medical history and ante-mortem functional status. SCAP data are submitted to the central adjudication panel for classification similar to WHIMS. SCAP is ongoing.
Related Papers
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,...
Keywords: Atrial Fibrillation; Rare Variant; Exome Chip
Investigating cognitive resilience in older women using machine learning: Women’s Health Initiative Memory Study
Keywords: Cognitive Resilience; Machine Learning; Older Women; Random Forests
Related Studies: 233
Clonal Hematopoiesis of Indeterminate Potential and the risk of mild cognitive impairment or probable dementia in the Women’s Health Initiative Memory Study
Keywords: Mild Cognitive Impairment; Probable Dementia; Risk Factor; Clonal Hematopoiesis Of Indeterminate Potential
Use of inverse probability of censoring weights in landmark estimation to address noncompliance in the Women’s Health Initiative Memory Study
Keywords: Survival Analysis; Treatment Effect; Intermediate Event Information; Inverse Probability Of Censoring Weights (Ipcw); Dependent Censoring; Compliance
Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants
OBJECTIVES: As people age and the incidence of dementia increases, studies of cognitive function continue to be of importance. Ascertaining cognitive data through different mechanisms is necessary to address missing data concerns. METHODS: The Dementia Questionnaire (DQ), which utilizes proxy-based assessments, is a potential tool to determine cognitive status in participants no longer being followed per traditional study protocol. The DQ is currently being used in the Supplemental Case Ascertai...
Keywords: Attrition; Cognitive Impairment; Dementia; Missing Data
Cognitive resilience among APOE e4 carriers in the oldest old
OBJECTIVE: Relatively few APOE e4+ carriers survive to old age (age 80+) without cognitive impairment (CI), thus little is known about distinguishing characteristics of resilient APOE e4+ carriers. Herein we describe the sociodemographic characteristics of a large sample of resilient APOE e4+ women from the Women's Health Initiative Memory Study (WHIMS) and compare them to non-carriers and APOE e4+ women who developed CI before age 80. METHODS: Women were recruited for clinical trials evaluating...
Keywords: Apoe; Cognitive Decline; Cognitive Resilience; Mild Cognitive Impairment; Dementia; Alzheimer’S Disease
Adherence to MIND Diet, genetic susceptibility, and incident dementia in three US cohorts
Adherence to Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) may lower the risk of dementia by impacting immunity and cholesterol, which are pathways also implicated by genome-wide association studies of Alzheimer's Dementia (AD). We examined whether adherence to the MIND diet could modify the association of genetic risk for AD with incident dementia. We used three ongoing US cohorts: Chicago Health and Aging Project (CHAP, n = 2449), Rush Memory and Aging Project (MAP, n...
Keywords: Mind; Cognitive Decline; Clinical Trial; Genetics; Alzheimer’S Disease
Plasma oxysterols are associated with serum lipids and dementia risk in older women
Introduction: Apolipoprotein E4 (APOE4) carriers' tendency toward hypercholesterolemia may contribute to Alzheimer's disease (AD) risk through oxysterols, which traverse the blood-brain barrier. Methods: Relationships between baseline plasma oxysterols, APOE status, serum lipids, and cognitive impairment risk were examined in 328 postmenopausal women from the Women's Health Initiative Memory Study. Women were followed for 25 years or until incident dementia or cognitive impairment. Results: Leve...
Keywords: Oxysterols; Blood Lipids; Apoe Gene; Dementia; Alzheimer’S Disease
Artificially sweetened beverages, stroke, coronary heart disease, and all-cause mortality in the Women's Health Initiative
Background and Purpose- We examine the association between self-reported consumption of artificially sweetened beverages (ASB) and stroke and its subtypes, coronary heart disease, and all-cause mortality in a cohort of postmenopausal US women. Methods- The analytic cohort included 81 714 women from the Women's Health Initiative Observational Study, a multicenter longitudinal study of the health of 93 676 postmenopausal women of ages 50 to 79 years at baseline who enrolled in 1993 to 1998. This p...
Keywords: Dementia; Soft Drinks; Diet Soda; Artificial And Sweetened Beverages; Stroke; Sugar
Plasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory St...
Keywords: Inflammation; Dementia; Alzheimer’S Disease; Proteomics; Diet
Association between blood pressure levels and cognitive impairment in older women: a prospective analysis of the Women's Health Initiative Memory Study
Background: Whether blood pressure (BP), and at what level of controlled BP, reduces risk of cognitive impairment remains uncertain. We investigated the association of BP and hypertension treatment status with mild cognitive impairment and dementia in older women. Methods: We prospectively analysed a sample of 7207 community-dwelling women aged 65-79 years participating in the Women's Health Initiative Memory Study (WHIMS). Participants were recruited between May 28, 1996, and Dec 13, 1999, at 3...
Keywords: Blood Pressure; Cognitive Function; Dementia
Association of visual impairment with risk of incident dementia in a Women's Health Initiative population
Importance: Dementia affects a large and growing population of older adults. Although past studies suggest an association between vision and cognitive impairment, there are limited data regarding longitudinal associations of vision with dementia. Objective: To evaluate associations between visual impairment and risk of cognitive impairment. Design, setting, and participants: A secondary analysis of a prospective longitudinal cohort study compared the likelihood of incident dementia or mild cogni...
Keywords: Visual Impairment; Vision; Cognitive Function; Dementia; Alzheimer’S Disease
A voxel-based morphometry study reveals local brain structural alterations associated with ambient fine particles in older women
Objective: Exposure to ambient fine particulate matter (PM2.5: PM with aerodynamic diameters < 2.5 µm) has been linked with cognitive deficits in older adults. Using fine-grained voxel-wise analyses, we examined whether PM2.5 exposure also affects brain structure. Methods: Brain MRI data were obtained from 1365 women (aged 71-89) in the Women's Health Initiative Memory Study and local brain volumes were estimated using RAVENS (regional analysis of volumes in normalized space). Based on geocoded ...
Keywords: Brain Aging; Air Pollution; Neurotoxicity; Geographic Locations
