W58 - CVD, diabetes, and renal biomarkers in the EA HT Cohort
Investigator Names and Contact Information
Introduction/Intent
In 2009 WHI approved measuring glucose, insulin, fasting lipid profile (total cholesterol, triglycerides, HDL and calculated LDL), CRP and creatinine in 12,000 African American and Hispanic women in the SHARe cohort (core study W54). The goal of the proposal was to measure biomarkers without which WHI is hampered in risk prediction for major cardiovascular disease.
To have a comparable sample of non-minority women, this core study will measure the same biomarkers in baseline bloods from 12,000 additional non-minority HT participants. The sampling scheme will ensure that measurements are performed in the most informative and representative cohort. See sample selection documentation under Study Documentation
As described, W58 – EA HT Biomarkers becomes part of a set of Core Studies that provide both GWAS and Biomarker data on approximately 22,000 women: 8,815 African Americans, 3,642 Hispanics, and 10,260 selected European Americans (EA) in the Hormone Trial (HT). Note that not all cases in M13-GARNET have corresponding biomarkers.
GWAS1
| Study ID | Description | #3 |
|---|---|---|
| M5 - SHARe | 8,515 Black + 3,641 Hispanic | 12,007 |
| M13 - GARNET4 | HT with CHD, stroke, VTE, diabetes, and matching controls (excludes those in SHARe; includes 1,400 from WHIMS) | 4,684 |
| W63 - WHIMS+ | WHIMS (excludes 1,400 EA HT in GARNET) | 4,661 |
| W63 - WHIMS+ | not GARNET, not WHIMS6 | 1,178 |
Biomarkers2
| Study ID | Description | #3 |
|---|---|---|
| W54 - SHARe CVD Biomarkers | Same as M5-SHARe | 12,007 |
| W58 - EA HT Biomarkers | All GARNET controls plus random selection of GARNET cases5 (excludes all WHIMS) | 3,067 |
| " | All WHIMS (includes 1,400 from GARNET and 4,661 from WHIMS+) | 6,061 |
| " | not GARNET, not WHIMS6 | 1,178 |
1 - dbGaP eligible
2 - insulin, glucose, CRP, creatinine, cholesterol, HDL, LDL, triglyceride
3 - Approximate number of sample results
4 - Number of participants with GWAS is about 5,060; not all cases had CVD biomarkers done in W58.
5 - Not all participants with GWAS in M13-GARNET have biomarkers; instead the 'not GARNET, not WHIMS' participants were added.
6 - Random selection of HT participants by age was added to provide a more balanced cross-section of HT participants
Results
Biomarkers were tested at the Advanced Research and Diagnostic Lab at the University of Minnesota (assay methodologies) Data available on this site Here.
Publications:
See publications: WHI publications by study lists published WHI papers that have been generated by ancillary studies. A complete list of WHI papers is available in the Papers of this website.
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
Name | Description |
|---|
Study Documents
Name | Description |
|---|---|
| NameW58 selection summary 05032011 (2).pdf | Description |
