W58 - CVD, diabetes, and renal biomarkers in the EA HT Cohort
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| NameW58 selection summary 05032011 (2).pdf | Description |
Related Papers
Social relationships, inflammation markers, and breast cancer incidence in the Women's Health Initiative
OBJECTIVES: Previous research has reported associations between social relationships and carcinogenesis. Inflammation is a potential mediator of these associations. To clarify these links for one tumor site, we examined associations between social relationships, circulating inflammation markers, and breast cancer incidence. MATERIALS AND METHODS: Among 132,262 participants from the prospective Women's Health Initiative, we used linear and logistic regression to evaluate associations between soci...
Keywords: Breast Cancer; Etiology; Incidence; Inflammation; Mediation; Social Relationship Characteristics
DXA versus clinical measures of adiposity as predictors of cardiometabolic diseases and all-cause mortality in postmenopausal women
Objective: To investigate whether dual-energy x-ray absorptiometry (DXA) estimates of adiposity improve risk prediction for cardiometabolic diseases over traditional surrogates, body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) in older women. Patients and methods: We analyzed up to 9744 postmenopausal women aged 50 to 79 years participating in the Women's Health Initiative who underwent a DXA scan and were free of cardiovascular disease and diabetes at baseline (Oct...
Keywords: Trunk Fat; Cardiovasular Outcomes; Postmenopausal Women
10-Year risk of atherosclerotic cardiovascular disease, hormone Therapy and cardiovascular disease outcomes in the Women’s Health Initiative hormone therapy trial
Keywords: Hormone Therapy; Cardiovascular Disease Risk; Pooled Cohort Equation; Coronary Heart Disease; Stroke
Kidney stones and the risk of chronic kidney disease among postmenopausal women: Results from The Women's Health Initiative
Keywords: Urinary Tract Stones; Chronic Kidney Disease; End-Stage Kidney Disease (Eskd); Mortality; Hazard Ratio; Postmenopausal Women
Lack of mediation by inflammatory biomarkers in the association between migraine and stroke among postmenopausal women: the Women’s Health Initiative
Keywords: Migraine; Stroke; Ischemic Stroke; Intracranial Hemorrhage; Stroke Mechanism; Inflammatory Biomarkers; C-Reactive Protein; Interleukin-6; And Tumor Necrosis Factor-Alpha
Relation of pregnancy loss to risk of cardiovascular disease in parous postmenopausal women (from the Women’s Health Initiative)
Women with history of pregnancy loss (PL) have higher burden of cardiovascular disease (CVD) later in life, yet it is unclear whether this is attributable to an association with established CVD risk factors (RFs). We examined whether PL is associated with CVD RFs and biomarkers in parous postmenopausal women in the Women's Health Initiative, and whether the association between PL and CVD RFs accounted for the association between PL and incident CVD. Linear and logistic regressions were used to e...
Keywords: Pregnancy Loss; Cardiovascular Risk Factors; Inflammatory Biomarkers; Hemostatic Biomarkers; Diabetes
Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women
PURPOSE: The purpose of this study was to examine the association of type II diabetes and anthropometric variables with risk of pancreatic cancer among postmenopausal women. METHODS: Weight, height, waist circumference, and hip circumference were measured by trained personnel, whereas history of diabetes and weight earlier in life were self-reported. Pancreatic cancer was ascertained via central review of medical records by physician adjudicators. After exclusions, 1045 cases of pancreatic cance...
Keywords: Adiposity; Body Mass Index; Waist Circumference; Waist-Hip Ratio; Serum Insulin; Pancreatic Cancer; Postmenopausal Women
DNA methylation-based estimator of telomere length
Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL (LTL) (r ~-0.75 for DNAmTL versus r ~ -0.35 for LTL). Leukocyte DNAmTL outperforms LTL in predicting: i) time-to-death (p=2.5E-20), ii) time-to-coronary heart disease (p=6.6E-5), iii) time-to-congestive heart failure (p...
Keywords: Dna Methylation; Leukocyte Telomere Length; Aging; Mortality; Cvd
Dietary Inflammatory Potential and the Risk of Incident Kidney Failure in the Women’s Health Initiative
Background: Diet affects inflammation and kidney health, but few studies have investigated dietary inflammatory potential in CKD progression, particularly in women. We aim to examine this association in the Women's Health Initiative (WHI). Methods: We conducted a non-concurrent prospective cohort study among WHI participants enrolled in the clinical trials and observational study (1993-1998) without baseline CKD and with available dietary intake assessments, Medicare data, and creatinine measure...
Keywords: Diet; Inflammation; End-Stage Renal Disease; Chronic Kidney Disease; Racial Disparities; Aging
Epigenome-wide association study of leukocyte telomere length
Abstract
Telomere length is associated with age-related diseases and is highly heritable. It is unclear, however, to what extent epigenetic modifications are associated with leukocyte telomere length (LTL). In this study, we conducted a large-scale epigenome-wide association study (EWAS) of LTL using seven large cohorts (n=5,713) - the Framingham Heart Study, the Jackson Heart Study, the Women's Health Initiative, the Bogalusa Heart Study, the Lothian Birth Cohorts of 1921 and 1936, and the Long...
Keywords: Dna Methylation; Leukocyte Telomere Length; Aging; Mortality; Cvd
