W54 - CVD Biomarkers for 2010-2015 (SHARe cohort only)
Investigator Names and Contact Information
Introduction/Intent
To measure glucose, insulin, fasting lipid profile (total cholesterol, triglycerides, HDL and calculated LDL), CRP and creatinine in baseline bloods from the WHI SHARe cohort. The WHI SHARe cohort includes approximately 8,515 self-identified African American women and 3,642 Hispanic women who provided consent for DNA analysis.
W54 becomes part of a set of Core Studies that provide both GWAS and Biomarker data on approximately 22,000 women: 8,815 African Americans, 3,642 Hispanics, and 10,260 selected European Americans (EA) in the Hormone Trial (HT). Note that not all cases in M13-GARNET have corresponding biomarkers.
GWAS1
| Study ID | Description | #3 |
|---|---|---|
| M5 - SHARe | 8,515 Black + 3,641 Hispanic | 12,007 |
| M13 - GARNET4 | HT with CHD, stroke, VTE, diabetes, and matching controls (excludes those in SHARe; includes 1,400 from WHIMS) | 4,684 |
| W63 - WHIMS+ | WHIMS (excludes 1,400 EA HT in GARNET) | 4,661 |
| W63 - WHIMS+ | not GARNET, not WHIMS6 | 1,178 |
Biomarkers2
| Study ID | Description | #3 |
|---|---|---|
| W54 - SHARe CVD Biomarkers | Same as M5-SHARe | 12,007 |
| W58 - EA HT Biomarkers | All GARNET controls plus random selection of GARNET cases5 (excludes all WHIMS) | 3,067 |
| " | All WHIMS (includes 1,400 from GARNET and 4,661 from WHIMS+) | 6,061 |
| " | not GARNET, not WHIMS6 | 1,178 |
1 - dbGaP eligible
2 - insulin, glucose, CRP, creatinine, cholesterol, HDL, LDL, triglyceride
3 - Approximate number of sample results
4 - Number of participants with GWAS is about 5,060; not all cases had CVD biomarkers done in W58.
5 - Not all participants with GWAS in M13-GARNET have biomarkers; instead the 'not GARNET, not WHIMS' participants were added.
6 - Random selection of HT participants by age was added to provide a more balanced cross-section of HT participants
Results
Biomarkers were tested at the Advanced Research and Diagnostic Lab at the University of Minnesota (assay methodologies)
Data available on this site Here.
Publications:
See publications: WHI publications by study lists published WHI papers that have been generated by ancillary studies. A complete list of WHI papers is available in the Papers of this website.
