AS311 - Global DNA methylation measured in prospectively collected blood samples and risk of bladder cancer among post-menopausal women
Investigator Names and Contact Information
Parveen Bhatti (pbhatti@fredhutch.org)
Introduction/Intent
Specific Aims Primary aim:
- To identify specific loci of DNA methylation (CpG loci), in pre-diagnostic specimens, whose methylation profiles are associated with risk of PTCC BC. Risk factors for BC will be controlled for in these analyses.
Secondary aims:
-
To evaluate if known and suspected bladder cancer risk factors, including smoking, air pollution, reproductive factors, dietary factors and germline genetic variants identified through genome-wide association studies act through an effect on DNA methylation. We will focus on the potential mediating effects of the CpG loci identified through our primary aim, but for the analysis of germline genetic variants we will also examine CpG loci that are proximal to these variants.
-
To construct BC prediction models with loci-specific methylation variables identified in the primary aim and to add known BC risk factors, including previously identified germline genetic variants.
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| Nameanc311 _memo_ September2013.doc | Description |
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