WHI Questionnaires

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Extension Study 2010-2025 (n=93,567)

Questionnaire	2010	2011	2012	2013	2014	2015	2016	2017	2018	2019	2020	2021	2022
33 Medical History Update	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y
151 Activities of Daily Life	Y		Y	Y	Y	Y	Y	Y	Y			#	P
151A Activities of Daily Life Collection begins January 1, 2022.													Y
151B Activities of Daily Life										Y	Y	^
153 Medication and Supplement Inventory			MR
155 Lifestyle Questionnaire		Y
156 Supplemental Questionnaire				Y
157 Supplemental Questionnaire 2014-15					Y
158 Supplemental Questionnaire 2017								Y
159 Supplemental Questionnaire 2018									Y
190P COVID-19 Survey											Y
191P COVID-19 Survey 2												Y
301 WHI Long Life Study Home Visit		LLS
330 Authorization to Release Medical Records										Y
521 Physical Activity Questionnaire *Form 521 in WHI started 6/22/2015 with a one-time administration.						Y
Questionnaire	2010	2011	2012	2013	2014	2015	2016	2017	2018	2019	2020	2021	2022

Legend

Y = All Participants
MR = Medical Record Cohort
LLS = Long Life Study
# = Collected from proxies throughout 2021, and from both participants and proxies from June through December 2021.
^ = Collected from participants only through May 2021.
P = Collected from proxies only.

Extension Study 2005-2010 (n=115,407)

Questionnaire	2005	2006	2007	2008	2009
33 Medical History Update	Y	Y	Y	Y	Y
33D Medical History Update (Detail) If an event that needed adjudication was found on the form 33, a 33D was collected.
85 Mammogram	HT	HT
134 Addendum to Medical History	Y
150 Hormone Use Update	HT	HT	HT	HT	HT
151 Activities of Daily Life	Y	Y	Y	Y	Y
153 Medication and Supplement Inventory				Y
154 Breast Health Supplement *All participants who previously reported diagnosis of breast cancer				%

Legend

Y = All Participants
HT = Hormone Trial
% = Subset, see notes for details

Clinical Trials & Observational Study

Questionnaire	Baseline	1	2	3	4	5	6	7	8	9	Closeout
2 Eligibility Screen	Y
4 Hormone Washout	HT
10 HRT Management and Safety Interview		HT	HT	HT	HT	HT	HT	HT	HT	HT	HT
17 CaD Management and Safety Interview		CaD	CaD	CaD	CaD	CaD	CaD	CaD	CaD	CaD	CaD
20 Personal Information	Y
25 Participant Treatment Assignment - E-alone *For E+P, when intervention stopped July 9, 2002. For E-Alone, when intervention stopped in February 2004.											HT
28 Participant Treatment Assignment - CaD *At CaD study close-out October 2004-March 2005.											CaD
30 Medical History	Y
31 Reproductive History	Y
32 Family History	Y
33 Medical History Update Collected every 6 months for HT ppts		Y	Y	Y	Y	Y	Y	Y	Y	Y	CT
33D Medical History Update (Detail) If an event that needed adjudication was found on the form 33, a 33D was collected.
34 Personal Habits	Y
35 Personal Habits Update		CT		CT			CT			CT
37 Thoughts and Feelings	Y										CT
38 Daily Life		CT		CT%/OS			CT%			CT%
39 Cognitive Assessment *HT cohort aged 65 and over.	HT%	HT%		HT%			HT%			HT%
40 Addendum to Medical History Update	Y
41 Addendum to Personal Information *Initiated in 2002 and collected once from all CT and OS participants at next routine contact.
42 Observational Study (Baseline)	OS
43 Hormone Use	Y
44 Current Medications	Y	CT		Y			CT			CT
45 Current Supplements	Y	CT		Y			CT			CT
48 OS Follow-up Questionnaire		OS
49 Estrogen Plus Progestin Survey *For E+P participants on study through July 8, 2002, when intervention was stopped; administration began in March 2003.
54 Change of (Study) Medications entered if ppt needed to modify their study medication dosage
55 Estrogen-Alone Survey *For all E-Alone participants; administered twice:
60 FFQ *Year 2: 30% cross sectional 33% rotating subsample starting in the year 2000, such that for year 3 and each subsequent year each DM participant received an FFQ at once every 3 years.	Y	DM	DM%	DM%/OS	DM%	DM%	DM%	DM%	DM%	DM%
80 Physical Measurements	Y	CT	CT	Y	CT	CT	CT	CT	CT	CT
81 Pelvic Exam	Y	HT	HT	HT	HT	HT	HT	HT	HT	HT
82 Endometrial Aspiration Administered as indicated and as needed to manage unexpected bleeding. Not required after July 9, 2002, when intervention was stopped. *5% E+P participants with uterus	HT			HT%			HT%			HT%
83 Transvaginal Uterine Ultrasound *Done only if endometrial aspiration could not be done or was refused.
84 Clinical Breast Exam *Optional for DM participants.	Y	HT	HT	HT	HT	HT	HT	HT	HT	HT
85 Mammogram	Y	HT	HT	HT	HT	HT	HT	HT	HT	HT	HT
86 ECG	CT			CT			CT			CT
87 Bone Density Scan *Collected for ppts enrolled at 3 clinical centers or about 6-7% of total WHI. Yr1 collection limited to CT	%	%		%			%			%
90 Functional Status *Sample was selected from the HT and DM > 65 years old.	CT%			CT%			CT%			CT%
92 Pap Smear	Y
100 Blood Collection and Processing *6% CT subsample. Year 6 collection was plasma only	Y	Y		CT%/OS			CT%/OS			CT%
101 Urine Collection and Processing *% - Collected at 3 BMD clinical centers. Year 9 collection was for 25% of OS ppts	CT/OS%	CT%		CT/OS%			CT%			OS%
143 OS Follow-up Year 3				OS
144 OS Follow-up Year 4					OS
145 OS Follow-up Year 5						OS
146 OS Follow-up Year 6							OS
147 OS Follow-up Year 7								OS
148 OS Follow-up Year 8									OS
149 Supplement to OS Follow-up Qx *For OS participants who did not reach Year 7 by Closeout											OS
Questionnaire	Baseline	1	2	3	4	5	6	7	8	9	Closeout

Legend

Y = All Participants
CT = All Clinical Trials
OS = Observation Studies
HT = Hormone Trial
CaD = Calcium/Vitamin D Trial
DM = Dietary Modification Trial
% = Subset, see notes for details