W19 - WHI HT Proteomic Pilot Study
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
Name | Description |
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Study Documents
Name | Description |
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| NameW19 HT proteomics selection summary 08-19-05.doc | Description |
Related Papers
Application of serum proteomics to the Women’s Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
The availability of serum collections from the Women's Health Initiative (WHI) conjugated equine estrogens (CEE) randomized controlled trial provides an opportunity to test the potential of in-depth quantitative proteomics to uncover changes in the serum proteome related to CEE and to assess their relevance to trial findings, including elevations in the risk of stroke and venous thromboembolism and a reduction in fractures.Five independent large scale quantitative proteomics analyses were perfor...
Keywords: Proteomics; Serum Proteome; Estrogen Replacement Therapy; Conjugated Equine Estrogens; Post-Menopause
Postmenopausal estrogen and progestin effects on the serum proteome
Women's Health Initiative randomized trials of postmenopausal hormone therapy reported intervention effects on several clinical outcomes, with some important differences between estrogen alone and estrogen plus progestin. The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated.Baseline serum samples were compared with samples drawn 1 year later for 50 women assigned to active hormone therapy in both the estrogen-plus-progestin and estrogen-alone r...
Keywords: Proteomics; Serum Proteome; Conjugated Equine Estrogens; Post-Menopausal Hormone Therapy
