AS620 - (PanScan 4) Whole Genome Scan for Pancreatic Cancer Risk

Cohort Consortium (PANSCAN)

Investigator Names and Contact Information

Laufey Amundadottir (amundadottirl@mail.nih.gov)

Rachael Stolzenberg-Solomon

Introduction/Intent

AS620 is Phase 4 of M4

Specific Aims

To conduct a GWAS study of pancreatic cancer by genotyping approximately 1,600 recently identified incident pancreatic cancer cases and controls with previous GWAS data drawn from cohort studies of the NCI cohort consortium.

1. Using a joint analysis of these and PanScan 1 and 2 data, we will identify novel regions of the genome associated with pancreatic cancer susceptibility. As needed, we will participate with the Pancreatic Cancer Case-Control Consortium (PanC4) for replication of findings
2. The genotype results and executive summaries of individual SNP analyses will be made available to bonafide researchers through a restricted-access website within several months of completion and following assessment of quality control.