AS534 - Longitudinal study of DNA methylation as a mediator between age and cardiovascular risk
Related Papers
Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of U.S. adults
Epigenetic mechanisms may underlie air pollution-health outcome associations. We estimated gaseous air pollutant-DNA methylation (DNAm) associations using twelve subpopulations within Women's Health Initiative (WHI) and Atherosclerosis Risk in Communities (ARIC) cohorts (n = 8397; mean age 61.3 years; 83% female; 46% African-American, 46% European-American, 8% Hispanic/Latino). We used geocoded participant address-specific mean ambient carbon monoxide (CO), nitrogen oxides (NO2; NOx), ozone (O3)...
Keywords: Epigenetics; Air Pollution; Epigenome-Wide Association Study; Dna Methylation; Carbon Monoxide; Nitrogen Dioxide; Nitrous Oxides; Ozone; Sulfur Dioxide
A longitudinal study of DNA methylation as a potential mediator of age-related diabetes risk
DNA methylation (DNAm) has been found to show robust and widespread age-related changes across the genome. DNAm profiles from whole blood can be used to predict human aging rates with great accuracy. We sought to test whether DNAm-based predictions of age are related to phenotypes associated with type 2 diabetes (T2D), with the goal of identifying risk factors potentially mediated by DNAm. Our participants were 43 women enrolled in the Women's Health Initiative. We obtained methylation data via ...
Keywords: Aging; Bmi; Dna Methylation; Biological Age; Biomarker; Diabetes
Epigenome-wide association study of diet quality in the Women's Health Initiative and TwinsUK cohort
Background: Diet quality is a risk factor for chronic disease and mortality. Differential DNA methylation across the epigenome has been associated with chronic disease risk. Whether diet quality is associated with differential methylation is unknown. This study assessed whether diet quality was associated with differential DNA methylation measured across 445 548 loci in the Women's Health Initiative (WHI) and the TwinsUK cohort. Design: The discovery cohort consisted of 4355 women from the WHI. ...
Keywords: Diet; Epigenetics; Insulin Resistance; Type 2 Diabetes
Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation
BACKGROUND: DNA methylation (DNAm) may contribute to processes that underlie associations between air pollution and poor health. Therefore, our objective was to evaluate associations between DNAm and ambient concentrations of particulate matter (PM) =2.5, =10, and 2.5-10 µm in diameter (PM2.5; PM10; PM2.5-10). METHODS: We conducted a methylome-wide association study among twelve cohort- and race/ethnicity-stratified subpopulations from the Women's Health Initiative and the Atherosclerosis Risk i...
Keywords: Epigenetics; Air Pollution; Epigenome-Wide Association Study; Dna Methylation; Particulate Matter
Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes
Background: Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DNAm. It is unclear how overall metabolic health outside of BMI may modify the relationship between BMI and methylation profiles, and what consequences this may have on downstream cardiovascular disease. The purpose of this study was to identify cytosine-phosphate-guanine (CpG) si...
