AS405 - Pharmacogenomics of risk factors for cardiac arrhythmias in global populations
Investigator Names and Contact Information
Christy Avery (christy_avery@unc.edu)
Related Papers
Diuretic-gene interactions affecting glucose homeostasis
Keywords: Diuretics; Lipids; Pharmacogenomics; Meta-Analysis; Genetic Modifiers
Related Studies: 405
A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium
BACKGROUND: Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals. METHODS AND RESULTS: We conducted race/ethnic-specific genome-wide interaction analyses (with HapMap phase II imputed reference panel imputation) of TCAs ...
Keywords: Pharmacogenomics; Qt Interval; Genetic Epidemiology; Genome-Wide Association Study; Gene-Based Tests
Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry
Keywords: Diuretics; Lipids; Pharmacogenomics; Meta-Analysis; Genetic Modifiers
Related Studies: 405
