AS271 - Omega-3 and omega-6 fatty acids as a biomarker of hip fracture risk
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
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Study Documents
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| NameAS271 selection summary 9-15-09b.pdf | Description |
Related Papers
The association of red blood cell n-3 and n-6 fatty acids to dietary fatty acid intake, bone mineral density and hip fracture risk in The Women’s Health Initiative
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) in red blood cells (RBCs) are an objective indicator of PUFA status and may be related to hip fracture risk. The primary objective of this study was to examine RBC PUFAs as predictors of hip fracture risk in postmenopausal women. A nested case-control study (n = 400 pairs) was completed within the Women's Health Initiative (WHI) using 201 incident hip fracture cases from the Bone Mineral Density (BMD) cohort, along with 199 addit...
Keywords: Omega 3 Fatty Acids; Omega 6 Fatty Acids; Bone Mineral Density; Hip Fracture; Osteoporosis
Related Studies: 271
TNF receptors predict hip fracture risk in the WHI study and fatty acid intake does not modify this association.
CONTEXT: Chronic inflammation may increase the risk of fracture, and omega-3 polyunsaturated fatty acids (PUFAs) may reduce fracture risk via down-regulation of inflammatory cytokine gene expression and other mechanisms. OBJECTIVE: We investigated associations between baseline samples of inflammatory markers, TNFa soluble receptors 1 and 2 (TNFa-sR1 and -sR2), and incident hip fracture. These associations were then tested for effect modification by dietary PUFA intake estimated by a baseline foo...
Keywords: Omega 3 Fatty Acids; Omega 6 Fatty Acids; Bone Turnover Markers; Inflammatory Markers; Bone Mineral Density
Related Studies: 271
