AS153 - Longitudinal changes in hip geometry and skeletal muscle

Investigator Names and Contact Information

Zhao Chen (zchen@u.arizona.edu)

Related Papers

Body composition and physical function in the Women’s Health Initiative Observational Study

Jennifer Bea et al., 2018/5 PubMed #30065910 MSID: 487
Physical function is critical for mobility and quality of life. We hypothesized that higher total lean mass is associated with higher physical function, and body fat inversely associated, among postmenopausal women. Women's Health Initiative Observational Study participants at Pittsburgh, PA; Birmingham, AL; and Tucson-Phoenix, AZ (1993-1998) completed dual-energy X-ray absorptiometry scans and the Rand SF-36 questionnaire at baseline and 3 y (N = 4526). Associations between quartiles (Q1-4) of ...
Keywords: Body Composition; Obese; Dxa
Related Studies: 153

Vitamin A and retinol intakes and the risk of fractures among participants of the Women's Health Initiative Observational Study

Graciela Caire-Juvera et al., 2008/12 PubMed #19056568 MSID: 633
Excessive intakes of vitamin A have been shown to have adverse skeletal effects in animals. High vitamin A intake may lead to an increased risk of fracture in humans.The objective was to evaluate the relation between total vitamin A and retinol intakes and the risk of incident total and hip fracture in postmenopausal women.A total of 75,747 women from the Women's Health Initiative Observational Study participated. The risk of hip and total fractures was determined using Cox proportional hazards ...
Keywords: None Provided
Related Studies: 153

Rheumatoid arthritis is associated with less optimal hip structural geometry

Nicole Wright et al., 2011/8 PubMed #21852170 MSID: 658
The overall goal of this study was to assess the longitudinal changes in bone strength in women reporting rheumatoid arthritis (RA; n=78) compared with nonarthritic control participants (n=4779) of the Women's Health Initiative bone mineral density (WHI-BMD) subcohort. Hip structural analysis program was applied to archived dual-energy X-ray absorptiometry scans (baseline, years 3, 6, and 9) to estimate bone mineral density (BMD) and hip structural geometry parameters in 3 femoral regions: narro...
Keywords: Rheumatoid Arthritis; Hip Geometry; Bmd
Related Studies: 153

Risk of mortality according to body mass index and body composition among postmenopausal women

Jennifer Bea et al., 2015/9 PubMed #26350478 MSID: 1522
Obesity, often defined as a body mass index (BMI; weight (kg)/height (m)(2)) of 30 or higher, has been associated with mortality, but age-related body composition changes can be masked by stable BMI. A subset of Women's Health Initiative participants (postmenopausal women aged 50-79 years) enrolled between 1993 and 1998 who had received dual-energy x-ray absorptiometry scans for estimation of total body fat (TBF) and lean body mass (LBM) (n = 10,525) were followed for 13.6 (standard deviation, 4...
Keywords: None Provided
Related Studies: 153

Calcium plus vitamin D supplementation has limited effects on femoral geometric strength in older postmenopausal women: The Women's Health Initiative

Rebecca Jackson et al., 2011/1 PubMed #21253715 MSID: 547
Calcium plus vitamin D (CaD) supplementation has a modest but significant effect on slowing loss of femoral bone mass and reducing risk of hip fractures in adherent postmenopausal women. The goal of this study was to determine if CaD supplementation influences hip structural parameters that are associated with fracture risk. We studied 1,970 postmenopausal women enrolled in the Women's Health Initiative randomized controlled trial of CaD at one of three bone mineral density (BMD) clinical center...
Keywords: None Provided
Related Studies: 153

Hormone therapy improves femur geometry among ethnically diverse postmenopausal participants in the Women's Health Initiative Hormone Intervention Trials

Zhao Chen et al., 2008/7 PubMed #18665788 MSID: 340
Loss of bone strength underlies osteoporotic fragility fractures. We hypothesized that hormone interventions significantly improve the structural geometry of proximal femur cross-sections. Study participants were from the Women's Health Initiative hormone intervention trials: either the conjugated equine estrogen (CEE) only (N(placebo) = 447, N(CEE) = 422) trial or the estrogen (E) plus progestin (P) (N(placebo) = 441, N(E+P) = 503) trial, who were 50-79 yr old at baseline and were followed up t...
Keywords: Fracture Risk; Bone Density; Ethnic Variations; Hrt; Postmenopausal Women
Related Studies: 153

Does obesity really make the femur stronger? Bone Mineral Density, geometry and fracture incidence in the Women’s Health Initiative - Observational Study

Thomas Beck et al., 2009/3 PubMed #19292617 MSID: 489
Heavier individuals have higher hip BMD and more robust femur geometry, but it is unclear whether values vary in proportion with body weight in obesity. We studied the variation of hip BMD and geometry across categories of body mass index (BMI) in a subset of postmenopausal non-Hispanic whites (NHWs) from the Women's Health Initiative Observational Cohort (WHI-OS). The implications on fracture incidence were studied among NHWs in the entire WHI-OS. Baseline DXA scans of hip and total body from 4...
Keywords: None Provided
Related Studies: 153

Ethnic differences in femur geometry in the Women’s Health Initiative Observational Study

Dorothy Nelson et al., 2010/8 PubMed #20737265 MSID: 566
Participants in the observational study of the Women's Health Initiative (WHI) were studied to determine if ethnic differences in femur geometry can help to explain differences in hip fracture rates. Structural differences in femurs of African and Mexican-American women appear to be consistent with lower rates of hip fractures vs. whites.Ethnic origin has a major influence on hip fractures, but the underlying etiology is unknown. We evaluated ethnic differences in hip fracture rates among 159,57...
Keywords: Bone Quality; Hip Structure Analysis; Cross-Sectional Geometry; Proximal Femur; Ethnicity
Related Studies: 153

Confounders in the association between exercise and femur bone in postmenopausal women

Thomas Beck et al., 2010/5 PubMed #20473223 MSID: 888
Abundant animal and human evidence demonstrates that loading stimuli generate positive adaptive changes in bone, but effects of activity on bone mineral density (BMD) are often modest and frequently equivocal.Physical activity effects on the femur would be better reflected in measurements of geometry than BMD.Cross-sectional cohort study.We used data from 6032 women of mixed ethnicity aged 50-79 yr who had dual-energy x-ray absorptiometry (DXA) scans of the total body and hip from the Women's He...
Keywords: None Provided
Related Studies: 153

Body mass index, waist circumference, and mortality in a large multiethnic cohort-results from the Women’s Health Initiative

Zhao Chen et al., 2017/2 PubMed #28229456 MSID: 960
OBJECTIVES: To determine whether the relationship between anthropometric measurements of obesity and mortality varies according to age, race, and ethnicity in older women. DESIGN: Prospective cohort study of multiethnic postmenopausal women. SETTING: Women's Health Initiative (WHI) observational study and clinical trials in 40 clinics. PARTICIPANTS: Postmenopausal women aged 50-79 participating in WHI (N = 161,808). MEASUREMENTS: Baseline height, weight, and waist circumference (WC) were measure...
Keywords: Bmi; Body Composition; Waist Circumference; Ethnicity; And Mortality
Related Studies: 153

Stronger bone correlates with African admixture in African American women

Zhao Chen et al., 2011/5 PubMed #21590740 MSID: 964
Osteoporosis affects all populations, but the risk for low bone density and fracture varies greatly by self-reported race and ethnicity. In this article, the relationship between measured percent African admixture and hip structural geometry, estimated from the hip structural analysis (HSA) program, was examined in a subcohort of the Women's Health Initiative (WHI). The study sample included 793 African-American women and 8559 non-Hispanic white women. All the participants were postmenopausal, b...
Keywords: Aging; Hip Geometric Structure; Longitudinal Change; Ethnicity
Related Studies: 153, BA1

Hip structural geometry and incidence of hip fracture in postmenopausal women: What does it add to conventional bone mineral density?

Andrea LaCroix et al., 2009/9 PubMed #19756830 MSID: 569
Hip geometry measurements of outer diameter and buckling ratio at the intertrochanter and shaft of the hip dual energy X-ray absorptiometry (DXA) scan predicted incident hip fracture in postmenopausal women. These associations, independent of age, body size, clinical risk factors, and conventional areal bone mineral density, suggest hip geometry plays a role in fracture etiology and may aid in improving identification of older women at high fracture risk.This study examined whether hip geometry ...
Keywords: Fragility; Fractures; Bone Mechanical Strength; Geometry; Hip Fracture Risk
Related Studies: 153

Dual-energy X-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women

Zhao Chen et al., 2007/12 PubMed #18029498 MSID: 456
Assessing skeletal muscle mass (SMM) is critical in studying and detecting sarcopenia. Direct measurements by MRI or computerized tomography are expensive or high in radiation exposure. Dual-energy X-ray absorptiometry (DXA) is promising for body composition assessments, but the validity of DXA for predicting SMM in the elderly is still under investigation. The objective of this study was to assess the relationship between DXA-derived measurements of lean soft tissue mass (LSTM) and SMM in older...
Keywords: Skeletal Muscle Mass; Dxa; Smm; Muscle Mass
Related Studies: 153

The relationship between incidence of fractures and anemia in older multiethnic women

Zhao Chen et al., 2010/12 PubMed #21143442 MSID: 562
To prospectively examine the relationship between anemia and incident fractures of the hip, spine, and all skeletal sites in women from diverse racial and ethnic backgrounds enrolled in the Women's Health Initiative (WHI) Observational Study and Clinical Trials.Prospective cohort study.Forty WHI clinical centers across the United States.Postmenopausal women (n=160,080), mean age 63.2±7.2, were recruited and followed for an average of 7.8 years.Anemia was defined as hemoglobin levels at baseline ...
Keywords: Anemia; Ethnicity; Physical Performance; Muscle Strength; Reduced Muscle Density; Low Bone Density; Mortality
Related Studies: 153, M2

Hip geometry in diabetic women: implications for fracture risk

Rajesh Garg et al., 2012/6 PubMed #22726843 MSID: 897
Women with type 2 diabetes mellitus (T2DM) have a higher risk of fractures despite increased bone mineral density (BMD) as compared to women without diabetes. We hypothesized that bone strength is diminished in women with T2DM after accounting for lean body mass, which may contribute to their increased fracture risk.Participants from Women's Health Initiative Observational Study were included in this cross-sectional study. These analyses include 3 groups of women: 1) T2DM women on diet or oral h...
Keywords: Bone Density; Type 2 Diabetes; Hip Geometry
Related Studies: 153