AS140 - Air pollution and electrocardiographic abnormalities (environmental epidemiology of arrhythmogenesis in WHI)

Investigator Names and Contact Information

Eric Whitsel (eric_whitsel@med.unc.edu)

Related Papers

Depression, antidepressant use, heart rate variability, and risk of CVD in postmenopausal women

Approved Proposal, Whited, Matthew et al., 2010/6 MSID: 1232
Keywords: Depression; Heart Rate Variability; Antidepressant Medication; Epidemiology; Cardiovascular Disease
Related Studies: 140

Ambient air pollution and lung cancer risk among never-smokers in the Women’s Health Initiative

Publication, Gowda, Shilpa et al., 2018/12 MSID: 1159
Keywords: Air Pollution; Particulate Matter; Environment; Exposure; Cancer Incidence
Related Studies: 140, 150, 220

Farming history and pesticide exposure as risk factors for ALS deaths within the Women’s Health Initiative Observational Cohort; A nested case control study

Approved Proposal, Talbott, Evelyn et al., 2020/10 MSID: 4313
Keywords: Als; Amyotrophic Lateral Sclerosis; Motor Neuron Disease; Occupational; Environmental Exposures; Pesticides; Risk Factors
Related Studies: 140, 220, 251, 264, 315, 593

The impact of aircraft noise on acute sleep disruptions and other sleep problems in the Women’s Health Initiative

Approved Proposal, Costello, Jean et al., 2024/11 MSID: 5225
Keywords: Sleep Disruption; Aircraft Noise; Environmental Influence On Sleep; Stress; Environment
Related Studies: 140, 251, 481

Long-term air pollution and risk of amyotrophic lateral sclerosis mortality in the Women’s Health Initiative Cohort

Evelyn Talbott et al., 2022/10 PubMed #36220441 MSID: 3712
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no cure. Although the etiology of sporadic ALS is largely unknown, environmental exposures may affect ALS risk. Objective: We investigated relationships between exposure to long-term ambient particulate matter (PM) and gaseous air pollution (AP) and ALS mortality. Methods: Within the Women's Health Initiative (WHI) cohort of 161,808 postmenopausal women aged 50-79 years at baseline (1993-1998), we performed a ne...
Keywords: Als; Amyotrophic Lateral Sclerosis; Motor Neuron Disease; Air Pollution; Environmental Exposures; Risk Factors
Related Studies: 140, 220, 251, 264, 315

Metabolomic evaluation of air pollution-related bone damage and potential mediation

Approved Manuscript, Prada, Diddier et al., 2023/2 MSID: 4490
Keywords: Metabolomics; Air Pollution; Bone Mineral Density; Pm2.5; Pm10
Related Studies: 140, 264, 315, 564, BA24

Long-term exposure to aircraft noise and incidence of cardiovascular events in the Women’s Health Initiative

Approved Proposal, Nguyen, Daniel D. et al., 2017/6 MSID: 3396
Keywords: Aircraft Noise; Airport Noise; Cardiovascular Disease; Epidemiology; Noise Exposure
Related Studies: 140, 251, 481

The role of the income and racial residential segregation on obesity-related cancer mortality in the Women’s Health Initiative Randomized Clinical Trial and Observational Study

Approved Proposal, Pichardo, Margaret et al., MSID: 4685
Keywords: Neighborhood Segregation; Socioeconomic Status; Cancer Mortality; Obesity; Race And Ethnicity
Related Studies: 140

Ambient fine particulate matter exposure and myocardial ischemia in the Environmental Epidemiology of Arrhythmogenesis in the Women’s Health Initiative (EEAWHI)

Zhu-Ming Zhang et al., 2009/1 PubMed #19479017 MSID: 529
Ambient particulate matter (PM) air pollution is associated with coronary heart disease, but the pathways underlying the association remain to be elucidated.We studied the association between PM and ischemia among 57,908 Women's Health Initiative clinical trial participants from 1999-2003. We used the Minnesota Code criteria to identify ST-segment and T-wave abnormalities, and estimated T amplitude (microvolt) from resting, standard 12-lead electrocardiogram (ECG). We used U.S. Environmental Pro...
Keywords: Air Pollution; Myocardial Ischemia / Infarction; Bayesian Hierarchical Models; Exposure Measurement Error
Related Studies: 140

Accuracy of commercial geocoding: Assessment and implications

Eric Whitsel et al., 2006/7 PubMed #16857050 MSID: 388
Published studies of geocoding accuracy often focus on a single geographic area, address source or vendor, do not adjust accuracy measures for address characteristics, and do not examine effects of inaccuracy on exposure measures. We addressed these issues in a Women's Health Initiative ancillary study, the Environmental Epidemiology of Arrhythmogenesis in WHI.Addresses in 49 U.S. states (n = 3,615) with established coordinates were geocoded by four vendors (A-D). There were important difference...
Keywords: Accuracy; Geographic Information Systems; Air Pollution; Cardiovascular Diseases
Related Studies: 140

GIS approaches for the estimation of residential-level ambient PM concentrations

Duanping Liao et al., 2006/9 PubMed #16966091 MSID: 415
Spatial estimations are increasingly used to estimate geocoded ambient particulate matter (PM) concentrations in epidemiologic studies because measures of daily PM concentrations are unavailable in most U.S. locations. This study was conducted to a) assess the feasibility of large-scale kriging estimations of daily residential-level ambient PM concentrations, b) perform and compare cross-validations of different kriging models, c) contrast three popular kriging approaches, and d) calculate SE of...
Keywords: Geographic Information Systems; Kriging; Cross-Validation; Air Pollution.
Related Studies: 140

Hierarchical models for the effect of spatial interpolation error on the inferred relationship between ambient particulate matter exposure and cardiovascular health

Publication, Crooks, Jim et al., 2008/7 MSID: 389
Keywords: Bias; Cardiovascular Diseases; Air Pollution
Related Studies: 140

Ambient particulate matter air pollution and venous thromboembolism in the Women’s Health Initiative Hormone Therapy Trials

Regina Shih et al., 2010/10 PubMed #21036692 MSID: 854
The putative effects of postmenopausal hormone therapy on the association between particulate matter (PM) air pollution and venous thromboembolism (VTE) have not been assessed in a randomized trial of hormone therapy, despite its widespread use among postmenopausal women.In this study, we examined whether hormone therapy modifies the association of PM with VTE risk.Postmenopausal women 50-79 years of age (n = 26,450) who did not have a history of VTE and who were not taking anticoagulants were e...
Keywords: Deep Vein Thrombosis; Pulmonary Embolism; Air Pollution; Socioeconomic Status
Related Studies: 140, 220, W6

Sleep duration and risk of ischemic stroke in postmenopausal women

Jiu-Chiuan Chen et al., 2008/7 PubMed #18635832 MSID: 430
Many studies have shown a U-shape association between sleep duration and mortality, but epidemiological evidence linking cardiovascular diseases with habitual sleep patterns is limited and mixed.We conducted a prospective study on 93 175 older women (aged 50 to 79 years) in the Women's Health Initiative Observational study cohort to examine the risk of ischemic stroke in relation to self-reported sleep duration. Cox models were used to investigate the putative associations, adjusting for multipl...
Keywords: Insomnia; Cardiovascular Diseases; Risk Factors; Inflammation Mediators; Endocrine System
Related Studies: 39, 140

Estimating personal exposures from ambient air pollution measures: using meta-analysis to assess measurement error

Katie Holliday et al., 2014/1 PubMed #24220191 MSID: 608
Although ambient concentrations of particulate matter =10 µm (PM10) are often used as proxies for total personal exposure, correlation (r) between ambient and personal PM10 concentrations varies. Factors underlying this variation and its effect on health outcome-PM exposure relationships remain poorly understood.We conducted a random-effects meta-analysis to estimate effects of study, participant, and environmental factors on r; used the estimates to impute personal exposure from ambient PM10 co...
Keywords: Air Pollution; Atrioventricular / Ventricular Conduction And Their Abnormalities; Bayesian Hierarchical Models; Exposure Measurement Error
Related Studies: 140

Heart rate variability, ambient particulate matter air pollution, and glucose homeostasis: The Environmental Epidemiology of Arrhythmogenesis in the Women's Health Initiative

Eric Whitsel et al., 2009/2 PubMed #19208727 MSID: 850
Metabolic neuropathophysiology underlying the prediabetic state may confer susceptibility to the adverse health effects of ambient particulate matter <10 microm in diameter (PM(10)). The authors therefore examined whether impaired glucose homeostasis modifies the effect of PM(10) on heart rate variability in a stratified, random sample of 4,295 Women's Health Initiative clinical trial participants, among whom electrocardiograms and fasting blood draws were repeated at 3-year intervals from 1993 ...
Keywords: None Provided
Related Studies: 140

Longitudinal profile of insomnia and risk of major vascular disease in postmenopausal women

Approved Manuscript, Chen, Jiu-Chiuan et al., 2010/4 MSID: 710
Keywords: None Provided
Related Studies: 140

Air pollution-associated changes in biomarkers of diabetes risk

Katie Holliday et al., 2019/8 PubMed #31538138 MSID: 1464
Background: Ambient particulate matter (PM) and nitrogen oxide (NOx) air pollution may be diabetogenic. Objective: To examine longitudinal associations of short- and longer-term mean PM =10 µm (PM10), PM =2.5 µm (PM2.5), and NOx concentrations with five biomarkers of diabetes risk. Methods: We studied a stratified, random minority oversample of nondiabetic Women's Health Initiative clinical trials participants with biomarkers and geocoded participant address-specific mean air pollution concentra...
Keywords: Ambient Air Pollution; Neighborhood Environment; Diabetes; Glucose Homeostasis; Biomarkers; Measurement Error; Selection Bias
Related Studies: 140, 220

Ambient particulate air pollution and ectopy: The environmental epidemiology of arrhythmogenesis in Women's Health Initiative Study, 1999-2004

Duanping Liao et al., 2009/1 PubMed #18979352 MSID: 609
The relationships between ambient PM(2.5) and PM(10) and arrhythmia and the effect modification by cigarette smoking were investigated. Data from U.S. Environmental Protection Agency (EPA) air quality monitors and an established national-scale, log-normal kriging method were used to spatially estimate daily mean concentrations of PM at addresses of 57,422 individuals from 59 examination sites in 24 U.S. states in 1999-2004. The acute and subacute exposures were estimated as mean, geocoded addres...
Keywords: Air Pollution; Ectopy; Arrhythmias; Bayesian Hierarchical Models; Exposure Measurement Error
Related Studies: 140

Comparison of PM2.5 air pollution exposures and health effects associations using 11 different modeling approaches in the Women's Health Initiative Memory Study (WHIMS)

Melinda Power et al., 2024/1 PubMed #38226465 MSID: 4126
Background: Many approaches to quantifying air pollution exposures have been developed. However, the impact of choice of approach on air pollution estimates and health-effects associations remains unclear. Objectives: Our objective is to compare particulate matter with aerodynamic diameter ≤ 2.5 μ m ( PM 2.5 ) concentrations and resulting health effects associations using multiple estimation approaches previously used in epidemiologic analyses. Methods: We assigned annual PM 2.5 exposure estimat...
Keywords: Air Pollution; Particulate Matter; Ozone; Environmental Health; Environmental Epidemiology
Related Studies: 140, 150, 226, 251, 252, 264, 315, 552

The role of the income and racial residential segregation on ORC incidence in the Women’s Health Initiative Randomized Clinical Trial and Observational Study

Approved Proposal, Pichardo, Margaret et al., 2022/2 MSID: 4663
Keywords: Neighborhood Segregation; Socioeconomic Status; Cancer Incidence; Obesity; Race And Ethnicity
Related Studies: 140

Long-term aircraft noise exposure and risk of hypertension in postmenopausal women

Daniel D. Nguyen et al., 2022/12 PubMed #36502895 MSID: 2685
Background: Studies of the association between aircraft noise and hypertension are complicated by inadequate control for potential confounders and a lack of longitudinal assessments, and existing evidence is inconclusive. Objectives: We evaluated the association between long-term aircraft noise exposure and risk of hypertension among post-menopausal women in the Women's Health Initiative Clinical Trials, an ongoing prospective U.S. Methods: Day-night average (DNL) and night equivalent sound leve...
Keywords: Aircraft Noise; Airport Noise; Blood Pressure; Epidemiology; Noise Exposure
Related Studies: 140, 251, 481

Neighborhood socioeconomic status, green space, and walkability and risk for falls among postmenopausal women: The Women’s Health Initiative

Marilyn Wende et al., 2023/5 PubMed #37149415 MSID: 4068
Purpose: This study estimated associations between neighborhood socioeconomic status (NSES), walkability, green space, and incident falls among postmenopausal women and evaluated modifiers of these associations, including study arm, race and ethnicity, baseline household income, baseline walking, age at enrollment, baseline low physical functioning, baseline fall history, climate region, and urban-rural residence. Methods: The Women's Health Initiative recruited a national sample of postmenopaus...
Keywords: Built Environment; Neighborhood; Falls; Physical Activity; Injury
Related Studies: 140, 220, 251, 252, 264, 315, 442, 481

How neighborhood socioeconomic status, green space, and walkability are associated with risk for fracture among postmenopausal women: The Women’s Health Initiative

Marilyn Wende et al., 2023/7 PubMed #37149415 MSID: 4069
Purpose: This study estimated associations between neighborhood socioeconomic status (NSES), walkability, green space, and incident falls among postmenopausal women and evaluated modifiers of these associations, including study arm, race and ethnicity, baseline household income, baseline walking, age at enrollment, baseline low physical functioning, baseline fall history, climate region, and urban-rural residence. Methods: The Women's Health Initiative recruited a national sample of postmenopaus...
Keywords: Neighborhood Socioeconomic Status; Walkability; Green Space; Fracture; Postmenopausal
Related Studies: 140, 220, 251, 252, 264, 315, 442, 481