AS130 - Randomized controlled trial of fat reduction, calcium/Vitamin D supplementation, hormone replacement therapy, and risk of proliferative forms of benign breast disease
Data Dictionaries and Study Documentation
This section displays all study-related data dictionaries and study-related files. The investigators for this study will upload the datasets, data dictionaries, and other study-related files. Study-related files will be made available to the public one year after the completion of the ancillary study, with the exception of the datasets, which will only be available to those with a Data Distribution Agreement. Those will be available to those with permission to download and will appear as a download link next to the data dictionary
Data Dictionaries
Name | Description |
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| NameAS 130 Path Data Dictionary 060817.docx | Description |
Study Documents
Name | Description |
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| NameAS130 Participant Selection Document.docx | Description |
Related Papers
A randomized controlled trial of calcium plus vitamin D supplementation and risk of benign proliferative breast disease
Experimental evidence provides strong support for anti-carcinogenic effects of calcium and vitamin D with respect to breast cancer. Observational epidemiologic data also provide some support for inverse associations with risk. We tested the effect of calcium plus vitamin D supplementation on risk of benign proliferative breast disease, a condition which is associated with increased risk of breast cancer. We used the Women's Health Initiative randomized controlled trial. The 36,282 participants w...
Keywords: Fat; Benign Proliferative Epithelial Disorders; Breast
Related Studies: 130
Conjugated equine estrogen and risk of benign proliferative breast disease: A randomized controlled trial
Estrogens stimulate proliferation of breast epithelium and may therefore increase the risk of benign proliferative breast disease, a condition that is associated with increased risk of breast cancer. We tested the effect of conjugated equine estrogen (CEE) on risk of benign proliferative breast disease in the Women's Health Initiative (WHI) randomized controlled trial.In the WHI CEE trial, 10,739 postmenopausal women were randomly assigned to 0.625 mg/d of CEE or to placebo. Baseline and annual ...
Keywords: Fat; Benign Proliferative Epithelial Disorders; Breast
Related Studies: 130
Physical activity and risk of benign proliferative epithelial disorders of the breast, in the Women's Health Initiative
Background: Recreational physical activity (PA) has been shown to be inversely associated with breast cancer risk. However, the association of recreational PA with benign proliferative epithelial disorders (BPED) of the breast, conditions associated with increased risk of breast cancer, has not been adequately studied. Methods: We used data from an ancillary study of benign breast disease conducted among the 68 132 postmenopausal women (aged 50-79 at recruitment) participating in the Women's He...
Keywords: Benign Proliferative Epithelial Disorder; Recreational Physical Activity; Bmi
Related Studies: 130
Estrogen plus progestin and risk of benign proliferative breast disease
Women with benign proliferative breast disease are at increased risk of subsequent breast cancer. Estrogens and progesterone exert proliferative effects on mammary epithelium, and combined hormone replacement therapy has been associated with increased breast cancer risk. We tested the effect of conjugated equine estrogen plus progestin on the risk of benign proliferative breast disease in the Women's Health Initiative (WHI) randomized controlled trial. In the WHI trial of estrogen plus progestin...
Keywords: Fat; Benign Proliferative Epithelial Disorders; Breast
Related Studies: 130
Low-fat dietary pattern and risk of benign proliferative breast disease: A randomized, controlled dietary modification trial
Modifiable factors, including diet, might alter breast cancer risk. We used the Women's Health Initiative Dietary Modification trial to test the effect of the intervention on risk of benign proliferative breast disease, a condition associated with increased risk of, and considered to be on the pathway to, invasive breast cancer. The Women's Health Initiative Dietary Modification trial was a randomized, controlled, primary prevention trial conducted in 40 U.S. clinical centers from 1993 to 2005. ...
Keywords: Fat; Benign Proliferative Epithelial Disorders; Breast
Related Studies: 130
Alcohol and folate consumption and risk of benign proliferative epithelial disorders of the breast
Alcohol consumption has been associated with increased breast cancer risk and the increase in risk may be attenuated by adequate folate intake. However, their associations with the risk of benign proliferative epithelial disorders (BPEDs) of the breast, possible precursors of breast cancer, are not well understood. To investigate these associations, we conducted a cohort study among 68,132 postmenopausal women participating in the Women's Health Initiative randomized clinical trials. Women were ...
Keywords: Benign Proliferative Epithelial Disorders; Breast; Risk; Alcohol; Folate; Atypical Hyperplasia
Related Studies: 130
Menstrual and reproductive history, postmenopausal hormone use, and risk of benign proliferative epithelial disorders of the breast: A cohort study
Menstrual and reproductive history and postmenopausal hormone use are well-established risk factors for breast cancer. However, previous studies that have assessed these factors in association with risk of benign proliferative epithelial disorders (BPED) of the breast, putative precursors of breast cancer, have yielded inconsistent findings. To investigate these associations, we conducted a cohort study among 68,132 postmenopausal women enrolled in the Women's Health Initiative randomized clinic...
Keywords: Benign Proliferative Epithelial Disorders; Breast; Risk; Age At Menarche; Age At Menopause; Oral Contraceptive Use; Age At First Live Birth; Age At First Full-Term Pregnancy; Parity
Related Studies: 130
Cigarette smoking and risk of benign proliferative epithelial disorders of the breast in the Women's Health Initiative
To investigate the association between cigarette smoking and risk of benign proliferative epithelial disorders (BPED) of the breast.We used data from an ancillary study of benign breast disease that is being conducted in the Women's Health Initiative randomized clinical trials among 68,132 postmenopausal women aged 50-79 at recruitment. After following the trial participants for an average of 7.8 years, we had ascertained 294 incident cases with atypical hyperplasia and 1,498 incident cases with...
Keywords: Benign Proliferative Epithelial Disorders; Breast; Risk; Cigarette Smoking; Atypical Hyperplasia
Related Studies: 130
