AS622 - Biomarkers of oxidative stress, inflammation, and cardiac damage as markers of radiation-induced cardiovascular outcomes in breast cancer

Investigator Names and Contact Information

Alexi Vasbinder (avasbind@uw.edu)

Introduction/Intent

Survival rates from cancer have improved; however, many survivors experience treatmentinduced adverse effects including late-onset cardiovascular disease due to radiation therapy. Currently, there are limited strategies for predicting long-term cardiovascular outcomes, as research often neglects long-term outcomes. Rather, most studies focus on short-term cardiovascular outcomes in which investigation of biomarkers has focused on pathways of inflammation and cardiac damage; however, additional pathways have been relatively understudied, including the pathway of oxidative stress for which there is biologic plausibility of a role in cardiotoxicity. Biomarkers of oxidative stress, cardiac damage, and inflammation may provide insight into the mechanisms increasing the risk of late-onset cardiotoxicity in breast cancer survivors treated with radiation.

Aims.

1. To assess the associations of Year 3 serum biomarkers of (a) oxidative stress, (b) cardiac damage, and (c) inflammation with the development of late-onset cardiovascular outcomes in breast cancer survivors treated with radiation.
2. To examine the potential for right-sided radiation vs. left-sided radiation to modify the risk of late-onset cardiovascular outcomes and the association of serum biomarkers with late-onset cardiovascular outcomes in these women.