Subsample Definitions
| Subsample | Design | Component | % | Years | Detail | Required Operations |
|---|---|---|---|---|---|---|
| 6% CT Blood (Form 100) | Cohort | HT | 8.6% | 0, 1, 3, 6, 9 | Stratified by CC, hyst (HT), race; oversampling of minorities with goal of equity across clinics (same subsample as Form 80 [for hip/waist], and Form 38- Daily Life. DM subsample same as 4DFR) | Blood analyzed for 20 ‘core’ analytes: micronutrients, glucose, insulin, lipids |
| DM | 4.3% | |||||
| (CT) | (~6% CT cohort) | |||||
| FFQ (Form 60) | one-time | DM | 30% | 2 | Stratified by CC | Designed so that each participant is scheduled to complete an FFQ every 3 years after year 2 |
| Rotating cross-sectional | DM | 33% | Annually after year 2 | |||
| 4DFR (Form 62) | Cohort | DM | 4.6% | 0, 1 | Overlap with blood subsample in DM | 4DFRs collected, documented, and analyzed on subsample |
| 24 Hr Recall | Repeated, cross-sectional | DM | 1% | Annually | Selected annually | 24 Hr administered centrally |
| Cohort | DM | 4.6% | 3, 6, 9 | Same subsample as 4DFR | Note: 24 Hr replaced the 4DFR after year 1 | |
| Endometrial Aspiration (Form 82) | Cohort | HT with uterus | 5% | 3, 6, 9 | Stratified by CC | |
| Cognitive Function (Form 39) | Cohort | HT > 65 yrs old | 25% | 0, 1, 3, 6, 9 | Stratified by CC | |
| Daily Life (Form 38) | Cohort | HT | 8.6% | 3, 6, 9 | Stratified by CC, hyst (HT), race; oversampling of minorities with goal of equity across clinics (same as blood subsample) | |
| DM | 4.3% | |||||
| Functional Status (Form 90) | Cohort | HT and DM > 65 yrs old | 25% | 0, 3, 6, 9 | Stratified by CC, selected independently of Cognitive Function subsample | |
| OS-MPS (Measurement Precision Study) | one-time | OS | 1% | 0 | Stratified by CC, age, race/ethnicity, subject to consent | Repeat selected baseline measurements at 3 months, including blood sample |
| Waist/Hip Circumferences (Form 80) | Cohort | HT | 8.6% | 0, 1, 3, 6, 9 | Same as Blood (Form 100) | |
| DM | 4.3% | |||||
| (CT) | (~6% CT cohort) | |||||
| BMD | Cohort | CT and OS | All participants randomized/enrolled at 3 clinical centers, or about 6-7% of total WHI | Baseline, Y3, Y6, Y9; additional collection at Y1 for CT | Whole body, Hip, and Spine scans at each contact |
