This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Form 43 - Hormone Use

File Name	Data as of	Population	Data collected	One row per	Rows
f43_ctos_inv.dat	2/17/2024	CT+OS	Baseline	Participant	161,805

ID - WHI Participant Common ID

Col 1

N	Missing
161,805	0

F43DAYS - F43 Days since randomization/enrollment

Col 2

N	Missing	Min	Max	Mean	StdDev
161,805	0	-595	73	-53.237	51.547

F43AGE - Age when completed Form 43

Col 3

Computed from the date Form 43 was completed and the date of birth recorded on Form 2.

N	Missing	Min	Max	Mean	StdDev
161,805	0	49	83	63.487	7.231

RECENCY - Time since quitting HRT categorized

Col 4

Computed from Form 43. Time (years) from randomization/enrollment since quitting HRT use (unopposed estrogen and/or estrogen plus progesterone from pills or patch).

Value	Description	N	%
0	Non user	70,885	43.8
1	Past, <5 yrs	10,224	6.3
2	Past, 5 to <10 years	4,635	2.9
3	Past, >10 years	11,070	6.8
4	Current	64,855	40.1
	Missing	136	0.1%

OC - Oral contraceptive use ever

Col 5

Computed from Form 43. Indicator variable for ever use of oral contraceptives.

Value	Description	N	%
0	No	94,819	58.6
1	Yes	66,986	41.4

OCAGEMIN - Age first used OC

Col 6

Computed from Form 43. Age at first use of oral contraceptives.

N	Missing	Min	Max	Mean	StdDev
66,866	94,939	15	72	29.346	6.849

OCAGEMAX - Age last used OC

Col 7

Computed from Form 43. Age at last use of oral contraceptives.

N	Missing	Min	Max	Mean	StdDev
66,814	94,991	15	73	35.054	7.834

OCTIME - OC duration (years)

Col 8

Computed from Form 43. Total lifetime duration of use in years of oral contraceptives.

N	Missing	Min	Max	Mean	StdDev
66,937	94,868	0.083	47	5.28	5.242

OCBPREG - OC use before first term pregancy

Col 9

Value	Description	N	%
0	No	52,514	32.5
1	Yes	9,773	6
2	Never had full term pregnancy	4,343	2.7
	Missing	95,175	58.8%

OCBPTIME - OC use before first term preg duration (years)

Col 10

N	Missing	Min	Max	Mean	StdDev
9,562	152,243	0	26	2.807	2.574

DES - DES (diethylstilbestrol) use ever

Col 11

Value	Description	N	%
0	No	157,328	97.2
1	Yes	4,477	2.8

DESAGEMIN - Age started DES

Col 12

N	Missing	Min	Max	Mean	StdDev
4,469	157,336	15	74	27.209	5.772

DESAGEMAX - Age stopped DES

Col 13

N	Missing	Min	Max	Mean	StdDev
4,461	157,344	16	74	28.437	6.727

DESTIME - DES Duration (years)

Col 14

N	Missing	Min	Max	Mean	StdDev
4,473	157,332	0.083	44	0.869	2.339

DMPA - DMPA (depo-provera) use ever

Col 15

Value	Description	N	%
0	No	160,901	99.4
1	Yes	904	0.6

DMPAGEMIN - Age first used DMPA

Col 16

N	Missing	Min	Max	Mean	StdDev
900	160,905	16	71	38.563	10.974

DMPAGEMAX - Age last used DMPA

Col 17

N	Missing	Min	Max	Mean	StdDev
897	160,908	18	78	40.099	11.379

DMPATIME - DMPA duration (years)

Col 18

N	Missing	Min	Max	Mean	StdDev
901	160,904	0	26	1.512	2.653

DMPAFREQ - DMPA frequency of use

Col 19

Usage Notes:

Used in conjunction with DMPA frequency unit of measure (UOM)

N	Missing	Min	Max	Mean	StdDev
882	160,923	0	60	1.764	3.033

DMPAUOM - DMPA frequency UOM

Col 20

Usage Notes:

Used in conjunction with DMPA frequency of use

Value	Description	N	%
1	Day	9	0
2	Week	4	0
3	Month	520	0.3
4	Year	125	0.1
5	3 Months (Qtr)	197	0.1
	Missing	160,950	99.5%

TOTE - Unopposed estrogen use ever

Col 21

Computed from Form 43. Indicator for ever use of unopposed estrogen from pills or patches.

Value	Description	N	%
0	No	104,093	64.3
1	Yes	57,712	35.7

TOTECAT - Unopposed estrogen duration by category

Col 22

Computed from Form 43. Categorial variable of total duration in years of unopposed estrogen use from pills or patches.

Value	Description	N	%
0	None	104,093	64.3
1	<5 Years	21,435	13.2
2	5 to <10 Years	11,365	7
3	10 to <15 Years	8,890	5.5
4	15+ Years	16,020	9.9
	Missing	2	0%

TOTEMIN - Age first used unopposed estrogen

Col 23

Computed from Form 43. Age at first use of unopposed estrogen from pills or patches.

N	Missing	Min	Max	Mean	StdDev
57,712	104,093	20	79	48.397	8.535

TOTEMAX - Age last used unopposed estrogen

Col 24

Computed from Form 43. Age at last use of unopposed estrogen from pills or patches.

N	Missing	Min	Max	Mean	StdDev
57,605	104,200	20	81	59.413	8.961

TOTESTAT - Unopposed estrogen usage status

Col 25

Computed from Form 43. Unopposed estrogen use status (never, past, current) from pills or patches. Current means at the time Form 43 was completed.

Value	Description	N	%
0	Never used	104,235	64.4
1	Past user	20,866	12.9
2	Current user	36,597	22.6
	Missing	107	0.1%

TOTETIME - Lifetime unopposed estrogen duration

Col 26

Computed from Form 43. Total duration in years of unopposed estrogen use from pills or patches.

N	Missing	Min	Max	Mean	StdDev
57,710	104,095	0.25	54	10.067	9.082

TOTP - Estrogen + progesterone use ever

Col 27

Computed from Form 43. Indicator for ever use of estrogen plus progesterone from pills or patches.

Value	Description	N	%
0	No	119,708	74
1	Yes	42,097	26

TOTPCAT - Estrogen + progesterone duration by category

Col 28

Computed from Form 43. Categorial variable of total duration in years estrogen plus progesterone use from pills or patches.

Value	Description	N	%
0	None	119,708	74
1	<5 Years	21,249	13.1
2	5 to <10 Years	11,411	7.1
3	10 to <15 Years	6,359	3.9
4	15+ Years	3,076	1.9
	Missing	2	0%

TOTPMIN - Age first used estrogen + progesterone

Col 29

Computed from Form 43. Age at first use of estrogen plus progesterone from pills or patches.

N	Missing	Min	Max	Mean	StdDev
42,097	119,708	20	79	53.055	6.891

TOTPMAX - Age last used estrogen + progesterone

Col 30

Computed from Form 43. Age at last use of estrogen plus progesterone from pills or patches.

N	Missing	Min	Max	Mean	StdDev
42,050	119,755	21	80	59.261	7.077

TOTPSTAT - Estrogen + progesterone usage status

Col 31

Computed from Form 43. Total estrogen plus progesterone use status (never, past, current) from pills or patches. Current means at the time Form 43 was completed.

Value	Description	N	%
0	Never used	119,708	74
1	Past user	13,792	8.5
2	Current user	28,258	17.5
	Missing	47	0%

TOTPTIME - Lifetime estrogen + progest duration

Col 32

Computed from Form 43. Total duration in years of estrogen plus progesterone use from pills or patches.

N	Missing	Min	Max	Mean	StdDev
42,095	119,710	0.25	49	5.946	5.397

TOTH - HRT use ever

Col 33

Computed from Form 43. Indicator for ever use of unopposed estrogen and/or estrogen plus progesterone from pills or patches.

Value	Description	N	%
0	No	70,885	43.8
1	Yes	90,920	56.2

TOTHCAT - HRT duration by category

Col 34

Computed from Form 43. Categorial variable of total duration in years of unopposed estrogen and/or estrogen plus progesterone use from pills or patches.

Value	Description	N	%
0	None	70,885	43.8
1	< 5 Years	35,087	21.7
2	5 to < 10 Years	20,393	12.6
3	10 to < 15 Years	15,127	9.3
4	15+ Years	20,310	12.6
	Missing	3	0%

TOTHMIN - Age first used HRT

Col 35

Computed from Form 43. Age at first use of unopposed estrogen and/or estrogen plus progesterone from pills or patches.

N	Missing	Min	Max	Mean	StdDev
90,920	70,885	20	79	49.812	8.101

TOTHMAX - Age last used HRT

Col 36

Computed from Form 43. Age at last use of estrogen and/or estrogen plus progesterone from pills or patches.

N	Missing	Min	Max	Mean	StdDev
90,784	71,021	20	81	59.767	8.184

TOTHSTAT - HRT usage status

Col 37

Computed from Form 43. Total HRT (unopposed estrogen and/or estrogen plus progesterone) use status (never, past, current) from pills or patches. Current means at the time Form 43 was completed.

Value	Description	N	%
0	Never used	70,885	43.8
1	Past user	25,929	16
2	Current user	64,855	40.1
	Missing	136	0.1%

TOTHTIME - Lifetime HRT duration

Col 38

Computed from Form 43. Total duration in years of HRT (unopposed estrogen and/or estrogen plus progesterone) use from pills or patches.

N	Missing	Min	Max	Mean	StdDev
90,917	70,888	0	54.25	9.14	8.306

PCYCLE - Progesterone cycle during last PERT use

Col 39

Computed from Form 43. Progesterone cycle from last use of estrogen plus progesterone from pills or patch.

Value	Description	N	%
3	Premphase	212	0.1
4	Prempro - Every day	4,263	2.6
5	Prempro - Every other day	35	0
6	Prempro - Every week	0	0
7	Prempro - In cycles	182	0.1
8	Other	822	0.5
9	Every month	33,425	20.7
10	Every other month	216	0.1
11	Every three months	301	0.2
12	Every 4th month	46	0
	Missing	122,303	75.6%

TEST - Testosterone or other male hormone use

Col 40

Value	Description	N	%
0	No	161,542	99.8
1	Yes	263	0.2

TESTMIN - Age first used testosterone

Col 41

N	Missing	Min	Max	Mean	StdDev
229	161,576	20	73	47.157	11.177

TESTMAX - Age last used testosterone

Col 42

N	Missing	Min	Max	Mean	StdDev
228	161,577	21	76	51.886	11.81

TESTSTAT - Testosterone or other male hormone status

Col 43

Value	Description	N	%
0	Never used	161,542	99.8
1	Past user	145	0.1
2	Current user	83	0.1
	Missing	35	0%

TESTTIME - Testosterone or other male hormone duration (years)

Col 44

N	Missing	Min	Max	Mean	StdDev
228	161,577	0	32.5	4.587	6.057

ESTR - Estratest use

Col 45

Value	Description	N	%
0	No	160,338	99.1
1	Yes	1,467	0.9

ESTRMIN - Age first used estratest

Col 46

N	Missing	Min	Max	Mean	StdDev
1,455	160,350	27	77	54.698	6.998

ESTRMAX - Age last used estratest

Col 47

N	Missing	Min	Max	Mean	StdDev
1,450	160,355	31	79	57.992	6.513

ESTRSTAT - Estratest usage status

Col 48

Value	Description	N	%
0	Never used	160,338	99.1
1	Past user	312	0.2
2	Current user	1,138	0.7
	Missing	17	0%

ESTRTIME - Estratest duration (years)

Col 49

N	Missing	Min	Max	Mean	StdDev
1,452	160,353	0	34.5	3.294	4.408