This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

ECG - MI Novacode Serial Comparison

File Name	Data as of	Population	Data collected	One row per	Rows
ecg_mi_nova_ct_inv.dat	9/12/2005	CT	Main	ECG	116,914

For a summary of ECG data from CT participants, see the Feb. 2003 Progress Report, Section 6.5 ECG Data, page 6-5, for a short description, and Table 6.15 Cross-tabulation of ECG codes Suggesting an Incident MI and Locally Confirmed and Self-Reported MI, page 6-24.

ID - WHI Participant Common ID

Col 1

N	Missing
116,914	0

ECGBASEDAYS - Baseline ECG days since randomization

Col 2

N	Missing	Min	Max	Mean	StdDev
116,914	0	-313	5	-36.312	29.486

ECGBASENOVA - Baseline ECG MI novacode

Col 3

Usage Notes:

Use for comparison with a follow-up ECG Novacode.

Value	Description	N	%
5.0	No significant Q waves and no significant ST-T abnormalities	81,561	69.8
5.1	Q wave MI with major Q waves	215	0.2
5.2	Q wave MI with moderate Q waves and with ST-T abnormalities	136	0.1
5.3	Possible Q wave MI w/moderate Q waves w/o ST-T abnormalities	898	0.8
5.4	Possible Q wave MI w/minor Q waves with ST-T abnormalities	604	0.5
5.5	Profound ST-T abnormalities without Q waves	2,075	1.8
5.6	Significant ST-T abnormalities without Q waves	1,676	1.4
5.7	Minor Q waves without ST-T abnormalities	10,280	8.8
5.8	Minor ST-T abnormalities	19,469	16.7
5.6.1	STD or TN score >= 20 in any lead group	0	0
5.6.2	Q score < 15 in all lead groups	0	0

ECGFUDAYS - Follow-up ECG days since randomization

Col 4

N	Missing	Min	Max	Mean	StdDev
116,914	0	353	3,861	1,787.064	710.909

ECGFUVTYP - Follow-up ECG visit type

Col 5

Value	Description	N	%
2	Semi-annual	607	0.5
3	Annual	116,253	99.4
4	Non-routine	50	0
	Missing	4	0%

ECGFUVY - Follow-up ECG visit year

Col 6

N	Missing	Min	Max	Mean	StdDev
116,860	54	1	11	4.875	1.95

ECGVCLO - Closest to visit (follow-up ECG)

Col 7

For forms entered with the same visit type and year, indicates the one closest to that visit's target date. Valid for forms entered with an annual or semi-annual visit type.

Usage Notes:

See Data Preparation Document.

Value	Description	N	%
0	No	205	0.2
1	Yes	116,709	99.8

ECGEXP - Expected for visit (follow-up ECG)

Col 8

The ECG was expected for this visit. ECGs were expected at screening (baseline) and at years 3, 6 and 9.

Value	Description	N	%
0	No	2,220	1.9
1	Yes	114,694	98.1

ECGFUNOVA - Follow-up ECG MI novacode

Col 9

Value	Description	N	%
5.0	No significant Q waves and no significant ST-T abnormalities	75,691	64.7
5.1	Q wave MI with major Q waves	317	0.3
5.2	Q wave MI with moderate Q waves and with ST-T abnormalities	228	0.2
5.3	Possible Q wave MI w/moderate Q waves w/o ST-T abnormalities	1,166	1
5.4	Possible Q wave MI w/minor Q waves with ST-T abnormalities	1,002	0.9
5.5	Profound ST-T abnormalities without Q waves	3,015	2.6
5.6	Significant ST-T abnormalities without Q waves	2,085	1.8
5.7	Minor Q waves without ST-T abnormalities	12,724	10.9
5.8	Minor ST-T abnormalities	20,686	17.7
5.6.1	STD or TN score >= 20 in any lead group	0	0
5.6.2	Q score < 15 in all lead groups	0	0

ECGINCDNTNOVA - Incident novacode

Col 10

Usage Notes:

Based on serial ECG comparison. Reference: Rautaharju, P, et al. The Novacode criteria for classification of ECG abnormalities and their clinically significant progression and regression. J Electrocardiol. 1998 Jul;31(3):157-187.

Value	Description	N	%
5.0	No significant Q waves and no significant ST-T abnormalities	109,219	93.4
5.1	Q wave MI with major Q waves	48	0
5.2	Q wave MI with moderate Q waves and with ST-T abnormalities	82	0.1
5.3	Possible Q wave MI w/moderate Q waves w/o ST-T abnormalities	328	0.3
5.4	Possible Q wave MI w/minor Q waves with ST-T abnormalities	147	0.1
5.5	Profound ST-T abnormalities without Q waves	593	0.5
5.6	Significant ST-T abnormalities without Q waves	3	0
5.7	Minor Q waves without ST-T abnormalities	4,192	3.6
5.8	Minor ST-T abnormalities	2	0
5.6.1	STD or TN score >= 20 in any lead group	342	0.3
5.6.2	Q score < 15 in all lead groups	1,958	1.7

ECGSILNTMI - Silent MI (evolving Q-wave; first occurrence)

Col 11

First occurrence of an evolving Q-wave MI based on an incident Novacode of 5.1 or 5.2.

Usage Notes:

WHI-CCC does not count a silent MI occurring after a clinical MI.

Value	Description	N	%
0	No	116,794	99.9
1	Yes	120	0.1

ECGPOSMI - Possible silent MI (first occurrence)

Col 12

First occurrence of a possible evolving Q-wave MI based on an incident Novacode of 5.3 or 5.4.

Usage Notes:

WHI-CCC does not count a silent MI occurring after a clinical MI.

Value	Description	N	%
0	No	116,476	99.6
1	Yes	438	0.4