This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Fracture Outcome Details (Form 123), CaD ppts

File Name	Data as of	Population	Data collected	One row per	Rows
outc_fracture_cad_inv.dat	2/17/2024	CaD	Main, Ext1	Outcome Form	5,339

This file contains outcomes collected through the end of Ext1. This file has one row for every form 123 recording outcome(s). A participant may have more than one of these forms. Only the first occurrence of each outcome is counted, e.g. Limiting the file to rows where BKANKLE=1 will find a single row for each participant with an ankle fracture outcome.

ID - WHI Participant Common ID

Col 1

N	Missing
5,339	0

ASCSOURCE - Ascertainment Source

Col 2

Value	Description	N	%
1	Local Form 123	4,528	84.8
2	Central Form 123	811	15.2

BKANKLE - Ankle Fracture

Col 3

Usage Notes:

Ankle Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Ankle Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	663	12.4
	Missing	4,676	87.6%

BKCARPAL - Carpal Fracture

Col 4

Carpal bones in wrist

Usage Notes:

Carpal Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Carpal Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	86	1.6
	Missing	5,253	98.4%

BKCLAVICLE - Clavical Fracture

Col 5

Usage Notes:

Clavical Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Clavical Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	69	1.3
	Missing	5,270	98.7%

BKELBOWNOS - Elbow NOS Fracture

Col 6

Elbow, not otherwise specified

Usage Notes:

Elbow NOS Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Elbow NOS Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	13	0.2
	Missing	5,326	99.8%

BKHIP - Hip Fracture

Col 7

Usage Notes:

This file contains outcomes collected through Ext1.

Value	Description	N	%
0	No	0	0
1	Yes	812	15.2
	Missing	4,527	84.8%

BKLELBOW - Lower End of Humerus Fracture

Col 8

Usage Notes:

Lower End of Humerus Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Lower End of Humerus Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	45	0.8
	Missing	5,294	99.2%

BKHAND - Metacarpal Fracture

Col 9

Usage Notes:

Metacarpal Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Metacarpal Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	127	2.4
	Missing	5,212	97.6%

BKPATELLA - Patella Fracture

Col 10

Usage Notes:

Patella Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Patella Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	171	3.2
	Missing	5,168	96.8%

BKPELVIS - Pelvis Fracture

Col 11

Usage Notes:

Pelvis Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Pelvis Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	164	3.1
	Missing	5,175	96.9%

BKLARM - Radius or Ulna Fracture

Col 12

Usage Notes:

Radius or Ulna Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Radius or Ulna Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	1,044	19.6
	Missing	4,295	80.4%

BKCOCCYX - Sacrum or Coccyx Fracture

Col 13

Usage Notes:

Sacrum or Coccyx Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Sacrum or Coccyx Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	43	0.8
	Missing	5,296	99.2%

BKSCAPULA - Scapula Fracture

Col 14

Usage Notes:

Scapula Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Scapula Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	14	0.3
	Missing	5,325	99.7%

BKUPPERLEG - Shaft of Femur Fracture

Col 15

Usage Notes:

Shaft of Femur Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Shaft of Femur Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	50	0.9
	Missing	5,289	99.1%

BKOHUMERUS - Shaft of Humerus Fracture

Col 16

Fracture of humerus, shaft or unspecified part

Usage Notes:

Shaft of Humerus Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Shaft of Humerus Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	39	0.7
	Missing	5,300	99.3%

BKFOOT - Tarsal or Metatarsal Fracture

Col 17

Usage Notes:

Tarsal or Metatarsal Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tarsal or Metatarsal Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	618	11.6
	Missing	4,721	88.4%

BKTIBIAFIBULA - Tibia or Fibula Fracture

Col 18

Usage Notes:

Tibia or Fibula Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tibia or Fibula Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	294	5.5
	Missing	5,045	94.5%

BKTIBIAL - Tibial Plateau Fracture

Col 19

Usage Notes:

Tibial Plateau Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tibial Plateau Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	89	1.7
	Missing	5,250	98.3%

BKUHUMERUS - Upper End of Humerus Fracture

Col 20

Usage Notes:

Upper End of Humerus Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Upper End of Humerus Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	417	7.8
	Missing	4,922	92.2%

BKUELBOW - Upper Radius/Ulna Fracture

Col 21

Usage Notes:

Upper Radius/Ulna Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Upper Radius/Ulna Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	200	3.7
	Missing	5,139	96.3%

BKSPINE - Vertebral Fracture

Col 22

Usage Notes:

Defined as the first occurrence of Lumbar Spine Fracture or Thoracic Spine Fracture. Vertebral Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Does not include cervical fractures.

Value	Description	N	%
0	No	0	0
1	Yes	381	7.1
	Missing	4,958	92.9%

HIPFSITE - Fracture site (hip)

Col 23

Value	Description	N	%
1	Neck of femur	505	9.5
2	Intertrochanteric fracture	257	4.8
3	Greater trochanter	29	0.5
4	Unspecified part of proximal femur	21	0.4
	Missing	4,527	84.8%

HIPFSIDE - Side of hip fracture

Col 24

Value	Description	N	%
1	Right	404	7.6
2	Left	407	7.6
3	Both sides	1	0
9	Unknown	0	0
	Missing	4,527	84.8%

HIPFBASE - Hip Fracture Based On

Col 25

Usage Notes:

Not collected on early versions of F123. Value 5 was not collected after WHI closeout.

Value	Description	N	%
1	Radiology & discharge summary dx new hip fracture	677	12.7
2	Radiology dx of hip fx, but not on discharge summary	44	0.8
3	Discharge, equiv. xray, unequiv. scan/MRI dx hip fx	15	0.3
4	Hip fracture dx in discharge summary, but no radiology rprt	75	1.4
5	Uncertain radiology report of hip fracture without add. doc	1	0
	Missing	4,527	84.8%

HIPFPATH - Pathologic fracture (of hip)

Col 26

Pathologic hip fracture: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone or joint prostheses, or surgical manipulation.Osteoporotic fracture is not considered a pathologic fracture.)

Value	Description	N	%
0	No	767	14.4
1	Yes	29	0.5
2	Possible	16	0.3
	Missing	4,527	84.8%

FRACSIDE - F123 Side of fracture (non hip)

Col 27

Usage Notes:

Not collected after WHI closeout.

Value	Description	N	%
1	Right	1,951	36.5
2	Left	2,068	38.7
3	Both sides	30	0.6
4	Not applicable (e.g. tailbone)	380	7.1
9	Unknown	32	0.6
	Missing	878	16.4%

FRACCONF - F123 Fracture confirmed as (non hip)

Col 28

Usage Notes:

Not collected after WHI closeout.

Value	Description	N	%
1	Non vertebal: Radiology report new fracture	3,177	59.5
2	Non vertebal: Radiology report healing fracture	107	2
3	Non vertebal: Non radiology report new/healing fracture	917	17.2
4	Non vertebal: Init. rad.report equiv., subs report dx fract.	43	0.8
5	Vertebal: Radiology report based on AP/lateral thoracolumbar	172	3.2
6	Vertebal: Radiology rprt not based AP/lateral thoracolumbar	68	1.3
	Missing	855	16%

FRACPATH - F123 Pathologic fracture (non hip)

Col 29

Pathologic fracture other than hip: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone and joint prostheses, or surgical manipulation. Osteoporotic fracture is not considered a pathologic fracture.)

Usage Notes:

Not collected after WHI closeout. Non vertebral fractures are not counted if they are pathologic.

Value	Description	N	%
0	No	4,281	80.2
1	Yes	13	0.2
2	Possible	27	0.5
	Missing	1,018	19.1%