This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Fracture Outcome Details (Form 123)

File Name	Data as of	Population	Data collected	One row per	Rows
outc_fracture_inv.dat	2/17/2024	CT+OS	Main, Ext1, Ext2	Outcome Form	15,453

This file has one row for every form 123 recording outcome(s). A participant may have more than one of these forms. Only the first occurrence of each outcome is counted, e.g. Limiting the file to rows where BKANKLE=1 will find a single row for each participant with an ankle fracture outcome.

ID - WHI Participant Common ID

Col 1

N	Missing
15,453	0

ASCSOURCE - Ascertainment Source

Col 2

Value	Description	N	%
1	Local Form 123	10,477	67.8
2	Central Form 123	4,976	32.2

BKANKLE - Ankle Fracture

Col 3

Usage Notes:

Ankle Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Ankle Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	1,482	9.6
	Missing	13,971	90.4%

BKCARPAL - Carpal Fracture

Col 4

Carpal bones in wrist

Usage Notes:

Carpal Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Carpal Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	205	1.3
	Missing	15,248	98.7%

BKCLAVICLE - Clavical Fracture

Col 5

Usage Notes:

Clavical Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Clavical Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	161	1
	Missing	15,292	99%

BKELBOWNOS - Elbow NOS Fracture

Col 6

Elbow, not otherwise specified

Usage Notes:

Elbow NOS Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Elbow NOS Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	32	0.2
	Missing	15,421	99.8%

BKHIP - Hip Fracture

Col 7

Usage Notes:

Hip Fracture was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort.

Value	Description	N	%
0	No	0	0
1	Yes	4,980	32.2
	Missing	10,473	67.8%

BKLELBOW - Lower End of Humerus Fracture

Col 8

Usage Notes:

Lower End of Humerus Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Lower End of Humerus Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	114	0.7
	Missing	15,339	99.3%

BKHAND - Metacarpal Fracture

Col 9

Usage Notes:

Metacarpal Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Metacarpal Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	299	1.9
	Missing	15,154	98.1%

BKPATELLA - Patella Fracture

Col 10

Usage Notes:

Patella Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Patella Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	388	2.5
	Missing	15,065	97.5%

BKPELVIS - Pelvis Fracture

Col 11

Usage Notes:

Pelvis Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Pelvis Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	415	2.7
	Missing	15,038	97.3%

BKLARM - Radius or Ulna Fracture

Col 12

Usage Notes:

Radius or Ulna Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Radius or Ulna Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	2,437	15.8
	Missing	13,016	84.2%

BKCOCCYX - Sacrum or Coccyx Fracture

Col 13

Usage Notes:

Sacrum or Coccyx Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Sacrum or Coccyx Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	120	0.8
	Missing	15,333	99.2%

BKSCAPULA - Scapula Fracture

Col 14

Usage Notes:

Scapula Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Scapula Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	43	0.3
	Missing	15,410	99.7%

BKUPPERLEG - Shaft of Femur Fracture

Col 15

Usage Notes:

Shaft of Femur Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Shaft of Femur Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	122	0.8
	Missing	15,331	99.2%

BKOHUMERUS - Shaft of Humerus Fracture

Col 16

Fracture of humerus, shaft or unspecified part

Usage Notes:

Shaft of Humerus Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Shaft of Humerus Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	93	0.6
	Missing	15,360	99.4%

BKFOOT - Tarsal or Metatarsal Fracture

Col 17

Usage Notes:

Tarsal or Metatarsal Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tarsal or Metatarsal Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	1,420	9.2
	Missing	14,033	90.8%

BKTIBIAFIBULA - Tibia or Fibula Fracture

Col 18

Usage Notes:

Tibia or Fibula Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tibia or Fibula Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	673	4.4
	Missing	14,780	95.6%

BKTIBIAL - Tibial Plateau Fracture

Col 19

Usage Notes:

Tibial Plateau Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tibial Plateau Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	186	1.2
	Missing	15,267	98.8%

BKUHUMERUS - Upper End of Humerus Fracture

Col 20

Usage Notes:

Upper End of Humerus Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Upper End of Humerus Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	915	5.9
	Missing	14,538	94.1%

BKUELBOW - Upper Radius/Ulna Fracture

Col 21

Usage Notes:

Upper Radius/Ulna Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Upper Radius/Ulna Fracture is not counted if pathologic.

Value	Description	N	%
0	No	0	0
1	Yes	416	2.7
	Missing	15,037	97.3%

BKSPINE - Vertebral Fracture

Col 22

Usage Notes:

Defined as the first occurrence of Lumbar Spine Fracture or Thoracic Spine Fracture. Vertebral Fracture was adjudicated during the core WHI study. They are adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Does not include cervical fractures.

Value	Description	N	%
0	No	0	0
1	Yes	952	6.2
	Missing	14,501	93.8%

HIPFSITE - Fracture site (hip)

Col 23

Value	Description	N	%
1	Neck of femur	2,793	18.1
2	Intertrochanteric fracture	1,927	12.5
3	Greater trochanter	151	1
4	Unspecified part of proximal femur	108	0.7
	Missing	10,474	67.8%

HIPFSIDE - Side of hip fracture

Col 24

Value	Description	N	%
1	Right	2,477	16
2	Left	2,496	16.2
3	Both sides	2	0
9	Unknown	2	0
	Missing	10,476	67.8%

HIPFBASE - Hip Fracture Based On

Col 25

Usage Notes:

Not collected on early versions of F123. Value 5 was not collected after WHI closeout.

Value	Description	N	%
1	Radiology & discharge summary dx new hip fracture	4,279	27.7
2	Radiology dx of hip fx, but not on discharge summary	230	1.5
3	Discharge, equiv. xray, unequiv. scan/MRI dx hip fx	98	0.6
4	Hip fracture dx in discharge summary, but no radiology rprt	362	2.3
5	Uncertain radiology report of hip fracture without add. doc	11	0.1
	Missing	10,473	67.8%

HIPFPATH - Pathologic fracture (of hip)

Col 26

Pathologic hip fracture: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone or joint prostheses, or surgical manipulation.Osteoporotic fracture is not considered a pathologic fracture.)

Value	Description	N	%
0	No	4,745	30.7
1	Yes	147	1
2	Possible	86	0.6
	Missing	10,475	67.8%

FRACSIDE - F123 Side of fracture (non hip)

Col 27

Usage Notes:

Not collected after WHI closeout.

Value	Description	N	%
1	Right	4,365	28.2
2	Left	4,816	31.2
3	Both sides	85	0.6
4	Not applicable (e.g. tailbone)	988	6.4
9	Unknown	87	0.6
	Missing	5,112	33.1%

FRACCONF - F123 Fracture confirmed as (non hip)

Col 28

Usage Notes:

Not collected after WHI closeout.

Value	Description	N	%
1	Non vertebal: Radiology report new fracture	7,255	46.9
2	Non vertebal: Radiology report healing fracture	254	1.6
3	Non vertebal: Non radiology report new/healing fracture	2,161	14
4	Non vertebal: Init. rad.report equiv., subs report dx fract.	125	0.8
5	Vertebal: Radiology report based on AP/lateral thoracolumbar	422	2.7
6	Vertebal: Radiology rprt not based AP/lateral thoracolumbar	148	1
	Missing	5,088	32.9%

FRACPATH - F123 Pathologic fracture (non hip)

Col 29

Pathologic fracture other than hip: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone and joint prostheses, or surgical manipulation. Osteoporotic fracture is not considered a pathologic fracture.)

Usage Notes:

Not collected after WHI closeout. Non vertebral fractures are not counted if they are pathologic.

Value	Description	N	%
0	No	9,930	64.3
1	Yes	36	0.2
2	Possible	66	0.4
	Missing	5,421	35.1%