This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Form 45 - Current Supplements

File Name	Data as of	Population	Data collected	One row per	Rows
f45_ctos_inv.dat	2/15/2025	CT+OS	Baseline, Main	Form	443,994

ID - WHI Participant Common ID

Col 1

N	Missing
443,994	0

F45DAYS - F45 Days since randomization/enrollment

Col 2

N	Missing	Min	Max	Mean	StdDev
443,994	0	-595	3,892	801.077	887.279

F45VTYP - Visit Type

Col 3

Value	Description	N	%
1	Screening Visit	161,806	36.4
2	Semi-Annual Visit	1,711	0.4
3	Annual Visit	279,804	63
4	Non-Routine Visit	673	0.2

F45VY - Visit year

Col 4

Visit year for which this form was collected.

N	Missing	Min	Max	Mean	StdDev
443,318	676	0	11	2.208	2.355

F45VCLO - Closest to visit within visit type and year

Col 5

For forms entered with the same visit type and year, indicates the one closest to that visit's target date. Valid for forms entered with an annual or semi-annual visit type.

Usage Notes:

See data preparation document.

Value	Description	N	%
0	No	1,501	0.3
1	Yes	442,493	99.7

F45EXPC - Expected for visit

Col 6

This form/data was expected for this visit. Form 45 (Current Supplements) was expected at Baseline for all CT and OS, for all CT at years 1, 3, 6, and 9, and for all OS at year 3.

Usage Notes:

This includes forms from the subsample of OS participants at year 6 that were enrolled in the three clinical centers participating in the WHI Osteoporosis sub study, as height and weight were collected on OS participants at year 6 by design; see table 16.1; on page 16-18b of volume 2.

Value	Description	N	%
0	No	8,110	1.8
1	Yes	435,884	98.2

F45VITA - Supplemental Vitamin A, mcg RE

Col 7

Average daily supplemental vitamin A, mcg RE

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	125,025	978.949	1,533.635

F45VITE - Supplemental Alpha-tocopherol, IU

Col 8

Average daily supplemental alpha-tocopherol, IU

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	20,458.571	180.575	301.249

F45VITB1 - Supplemental Vitamin B1 (Thiamine), mg

Col 9

Average daily supplemental vitamin B1 (Thiamine), mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	4,000	4.763	23.312

F45VTB12 - Supplemental Vitamin B12, mcg

Col 10

Average daily supplemental vitamin B12, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	6,226.286	18.318	81.089

F45VITB2 - Supplemental Vitamin B2 (Riboflavin), mg

Col 11

Average daily supplemental vitamin B2 (Riboflavin), mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	4,000	4.103	19.632

F45VITB6 - Supplemental Vitamin B6, mg

Col 12

Average daily supplemental vitamin B6, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	2,500	6.675	30.288

F45BETA - Supplemental Beta-carotene, mcg

Col 13

Average daily supplemental beta-carotene, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	500,000	2,646.57	4,333.832

F45BIOT - Supplemental Biotin, mcg

Col 14

Average daily supplemental biotin, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	16,800	8.623	76.873

F45VITC - Supplemental Vitamin C, mg

Col 15

Average daily supplemental vitamin C, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	40,365	277.289	574.96

F45CALC - Supplemental Calcium, mg

Col 16

Average daily supplemental calcium, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	95,314.286	378.907	589.111

F45CHROM - Supplemental Chromium, mcg

Col 17

Average daily supplemental chromium, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	18,000	6.31	64.52

F45COPP - Supplemental Copper, mg

Col 18

Average daily supplemental copper, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	360	0.949	2.08

F45VITD - Supplemental Vitamin D, mcg

Col 19

Average daily supplemental vitamin D, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	438.571	5.709	6.486

F45FOLIC - Supplemental Folic Acid, mcg

Col 20

Average daily supplemental folic acid, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	20,400	212.552	262.066

F45IRON - Supplemental Iron, mg

Col 21

Average daily supplemental iron, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	5,443.714	8.842	21.071

F45MAGN - Supplemental Magnesium, mg

Col 22

Average daily supplemental magnesium, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	45,357.143	68.901	151.507

F45MANG - Supplemental Manganese, mg

Col 23

Average daily supplemental manganese, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	200	0.261	2.244

F45MOLYB - Supplemental Molybdenum, mcg

Col 24

Average daily supplemental molybdenum, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	25,000	0.778	60.504

F45NIAC - Supplemental Niacin, mg

Col 25

Average daily supplemental niacin, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	32,020	22.573	118.766

F45PANTO - Supplemental Pantothenic Acid, mg

Col 26

Average daily supplemental pantothenic acid, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	6,000	4.213	32.029

F45RETIN - Supplemental Retinol, mcg

Col 27

Average daily supplemental retinol, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	82,500	533.703	955.98

F45SELEN - Supplemental Selenium, mcg

Col 28

Average daily supplemental selenium, mcg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	3,000	17.49	45.627

F45ZINC - Supplemental Zinc, mg

Col 29

Average daily supplemental zinc, mg

N	Missing	Min	Max	Mean	StdDev
443,994	0	0	922.143	8.386	13.552

F45MULTI - Multivitamin without Minerals

Col 30

Value	Description	N	%
0	No	429,666	96.8
1	Yes	14,328	3.2

F45MVMIN - Multivitamin with Minerals

Col 31

Value	Description	N	%
0	No	263,260	59.3
1	Yes	180,734	40.7

F45STRES - Stress Formula Pills

Col 32

Value	Description	N	%
0	No	433,744	97.7
1	Yes	10,250	2.3

F45OTHCM - Other Comb Pill (not multivit/stress)

Col 33

Value	Description	N	%
0	No	312,417	70.4
1	Yes	131,577	29.6

F45COMBP - Any Combination Pill

Col 34

Value	Description	N	%
0	No	185,058	41.7
1	Yes	258,936	58.3

TKVITA - F45 Taking vitamin A from single sup

Col 35

Value	Description	N	%
0	No	423,047	95.3
1	Yes	20,947	4.7

TKVITE - F45 Taking alpha-toco from single sup

Col 36

Value	Description	N	%
0	No	294,540	66.3
1	Yes	149,454	33.7

TKVITB1 - F45 Taking vitamin B1 from single sup

Col 37

Value	Description	N	%
0	No	439,686	99
1	Yes	4,308	1

TKVITB12 - F45 Taking vitamin B12 from single sup

Col 38

Value	Description	N	%
0	No	428,452	96.5
1	Yes	15,542	3.5

TKVITB2 - F45 Taking vitamin B2 from single sup

Col 39

Value	Description	N	%
0	No	440,898	99.3
1	Yes	3,096	0.7

TKVITB6 - F45 Taking vitamin B6 from single sup

Col 40

Value	Description	N	%
0	No	430,135	96.9
1	Yes	13,859	3.1

TKBETA - F45 Taking beta-carotene from single sup

Col 41

Value	Description	N	%
0	No	430,025	96.9
1	Yes	13,969	3.1

TKBIOT - F45 Taking biotin from single sup

Col 42

Value	Description	N	%
0	No	440,805	99.3
1	Yes	3,189	0.7

TKVITC - F45 Taking vitamin C from single sup

Col 43

Value	Description	N	%
0	No	330,812	74.5
1	Yes	113,182	25.5

TKCALC - F45 Taking calcium from single sup

Col 44

Value	Description	N	%
1	Yes	90,209	20.3
0	No	353,785	79.7

TKCHROM - F45 Taking chromium from single sup

Col 45

Value	Description	N	%
0	No	436,419	98.3
1	Yes	7,575	1.7

TKCOPP - F45 Taking copper from single sup

Col 46

Value	Description	N	%
0	No	442,372	99.6
1	Yes	1,622	0.4

TKVITD - F45 Taking vitamin D from single sup

Col 47

Value	Description	N	%
0	No	424,197	95.5
1	Yes	19,797	4.5

TKFOLIC - F45 Taking folic acid from single sup

Col 48

Value	Description	N	%
0	No	430,721	97
1	Yes	13,273	3

TKIRON - F45 Taking iron from single sup

Col 49

Value	Description	N	%
0	No	437,455	98.5
1	Yes	6,539	1.5

TKMAGN - F45 Taking magnesium from single sup

Col 50

Value	Description	N	%
0	No	432,191	97.3
1	Yes	11,803	2.7

TKMANG - F45 Taking manganese from single sup

Col 51

Value	Description	N	%
0	No	442,133	99.6
1	Yes	1,861	0.4

TKMOLYB - F45 Taking molybdenum from single sup

Col 52

Value	Description	N	%
0	No	443,763	99.9
1	Yes	231	0.1

TKNIAC - F45 Taking niacin from single sup

Col 53

Value	Description	N	%
0	No	436,500	98.3
1	Yes	7,494	1.7

TKPANTO - F45 Taking pantothenic acid from single sup

Col 54

Value	Description	N	%
0	No	441,179	99.4
1	Yes	2,815	0.6

TKRETIN - F45 Taking retinol from single sup

Col 55

Value	Description	N	%
0	No	434,298	97.8
1	Yes	9,696	2.2

TKSELEN - F45 Taking selenium from single sup

Col 56

Value	Description	N	%
0	No	431,738	97.2
1	Yes	12,256	2.8

TKZINC - F45 Taking zinc from single sup

Col 57

Value	Description	N	%
0	No	430,932	97.1
1	Yes	13,062	2.9

F45MVYR - Multivitamin without Minerals adult years taken

Col 58

Number of adult years using a multivitamin without minerals

N	Missing	Min	Max	Mean	StdDev
14,328	429,666	0.08	61.3	9.714	10.868

F45MVMYR - Multivitamin with Minerals adult years taken

Col 59

Number of adult years using a multivitamin with minerals

N	Missing	Min	Max	Mean	StdDev
180,734	263,260	0.08	65.25	8.535	9.488

F45STRYR - Stress Formula Pills adult years taken

Col 60

Number of adult years using a stress formula pill

N	Missing	Min	Max	Mean	StdDev
10,250	433,744	0.08	59	7.311	8.674

F45OTHYR - Other Comb Pill (not multivit/stress) adult years taken

Col 61

Number of adult years using an other combination pill

N	Missing	Min	Max	Mean	StdDev
131,577	312,417	0.08	63.49	6.626	7.317

F45CALCY - Calcium adult years taken

Col 62

Longest duration in years as an adult taking calcium from a combination pill or single supplement

N	Missing	Min	Max	Mean	StdDev
273,012	170,982	0.08	65.25	8.405	8.926

F45VITDY - Vitamin D adult years taken

Col 63

Longest duration in years as an adult taking vitamin D from a combination pill or single supplement

N	Missing	Min	Max	Mean	StdDev
239,750	204,244	0.08	65.25	8.5	9.296