This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Self-Reported Outcomes, Extension Study 2, MRC Participants

File Name	Data as of	Population	Data collected	One row per	Rows
outc_self_x2_mrc_inv.dat	2/15/2025	MRC	Ext2	Participant	22,316

A self report is only counted if the first report of that outcome occurred after the start of the extension 2 phase of the study.

ID - WHI Participant Common ID

Col 1

N	Missing	Min	Max	Mean	StdDev
22,316	0	100,004	299,997	200,492.7	57,496.836

F33ANGHOSP - F33 Hospitalized Angina

Col 2

Value	Description	N	%
0	No	20,299	91
1	Yes	2,017	9

F33ANGHOSPDY - Days enrollment to F33 Hospitalized Angina

Col 3

N	Missing	Min	Max	Mean	StdDev
2,017	20,299	4,718	10,948	7,202.947	1,486.969

F33COPD - F33 COPD

Col 4

COPD, emphysema, or chronic bronchitis

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	18,874	84.6
1	Yes	3,442	15.4

F33COPDDY - Days enrollment to F33 COPD

Col 5

N	Missing	Min	Max	Mean	StdDev
3,442	18,874	4,469	10,975	7,107.184	1,410.123

F33AFIBHSP - F33 Hospitalized Atrial Fibrillation

Col 6

Usage Notes:

Only collected during the WHI Extension Study 2

Value	Description	N	%
0	No	19,702	88.3
1	Yes	2,614	11.7

F33AFIBHSPDY - Days enrollment to F33 Hospitalized Atrial Fibrillation

Col 7

N	Missing	Min	Max	Mean	StdDev
2,614	19,702	4,469	11,277	7,030.145	1,409.585

F33AFIBOP - F33 Outpatient Atrial Fibrillation

Col 8

Value	Description	N	%
0	No	20,498	91.9
1	Yes	1,818	8.1

F33AFIBOPDY - Days enrollment to F33 Outpatient Atrial Fibrillation

Col 9

N	Missing	Min	Max	Mean	StdDev
1,818	20,498	4,515	11,183	7,436.662	1,415.732

F33NMSC - Non-Melanoma Skin Cancer

Col 10

Value	Description	N	%
0	No	21,410	95.9
1	Yes	906	4.1

F33NMSCDY - Days enrollment to F33 Non-Melanoma Skin Cancer

Col 11

N	Missing	Min	Max	Mean	StdDev
906	21,410	4,742	11,013	8,001.832	1,521.793

F33BKULEG - F33 Broken Upper Leg

Col 12

Value	Description	N	%
0	No	21,663	97.1
1	Yes	653	2.9

F33BKULEGDY - Days enrollment to F33 Broken Upper Leg

Col 13

N	Missing	Min	Max	Mean	StdDev
653	21,663	4,725	11,068	7,888.757	1,561.546

F33BKPELV - F33 Broken Pelvis

Col 14

Value	Description	N	%
0	No	21,672	97.1
1	Yes	644	2.9

F33BKPELVDY - Days enrollment to F33 Broken Pelvis

Col 15

N	Missing	Min	Max	Mean	StdDev
644	21,672	4,748	10,863	7,675.963	1,541.453

F33BKKNEE - F33 Broken Knee

Col 16

Value	Description	N	%
0	No	21,808	97.7
1	Yes	508	2.3

F33BKKNEEDY - Days enrollment to F33 Broken Knee

Col 17

N	Missing	Min	Max	Mean	StdDev
508	21,808	4,738	10,891	7,277.508	1,520.991

F33BKSPINE - F33 Broken Spine

Col 18

Value	Description	N	%
0	No	21,145	94.8
1	Yes	1,171	5.2

F33BKSPINEDY - Days enrollment to F33 Broken Spine

Col 19

N	Missing	Min	Max	Mean	StdDev
1,171	21,145	4,717	11,108	7,509.981	1,558.589

F33BKUARM - F33 Broken Upper Arm

Col 20

Value	Description	N	%
0	No	21,162	94.8
1	Yes	1,154	5.2

F33BKUARMDY - Days enrollment to F33 Broken Upper Arm

Col 21

N	Missing	Min	Max	Mean	StdDev
1,154	21,162	4,669	11,096	7,547.016	1,549.208

F33BKLARM - F33 Broken Lower Arm

Col 22

Value	Description	N	%
0	No	21,006	94.1
1	Yes	1,310	5.9

F33BKLARMDY - Days enrollment to F33 Broken Lower Arm

Col 23

N	Missing	Min	Max	Mean	StdDev
1,310	21,006	4,655	10,975	7,318.971	1,557.365

F33BKHAND - F33 Broken Hand

Col 24

Value	Description	N	%
0	No	22,012	98.6
1	Yes	304	1.4

F33BKHANDDY - Days enrollment to F33 Broken Hand

Col 25

N	Missing	Min	Max	Mean	StdDev
304	22,012	4,760	11,018	7,336.888	1,522.531

F33BKLLEG - F33 Broken Lower Leg

Col 26

Value	Description	N	%
0	No	21,493	96.3
1	Yes	823	3.7

F33BKLLEGDY - Days enrollment to F33 Broken Lower Leg

Col 27

N	Missing	Min	Max	Mean	StdDev
823	21,493	4,727	10,975	7,268.859	1,505.923

F33BKFOOT - F33 Broken Foot

Col 28

Value	Description	N	%
0	No	21,702	97.2
1	Yes	614	2.8

F33BKFOOTDY - Days enrollment to F33 Broken Foot

Col 29

N	Missing	Min	Max	Mean	StdDev
614	21,702	4,732	10,886	7,192.735	1,511.361

F33BKTAILBN - F33 Broken Tailbone

Col 30

Value	Description	N	%
0	No	22,115	99.1
1	Yes	201	0.9

F33BKTAILBNDY - Days enrollment to F33 Broken Tailbone

Col 31

N	Missing	Min	Max	Mean	StdDev
201	22,115	4,752	11,090	7,680.517	1,525.145

F33BKELBOW - F33 Broken Elbow

Col 32

Value	Description	N	%
0	No	22,038	98.8
1	Yes	278	1.2

F33BKELBOWDY - Days enrollment to F33 Broken Elbow

Col 33

N	Missing	Min	Max	Mean	StdDev
278	22,038	4,655	11,024	7,387.993	1,531.899

F33BKOTHBNX2 - F33 Broken Other Bone

Col 34

Broken other bone, Extension 2 definition.

Usage Notes:

This variable does not map to the Broken Other Bone (F33BKOTHBN) variable collected prior to Extension Study 2, as the form question changed.

Value	Description	N	%
0	No	19,997	89.6
1	Yes	2,319	10.4

F33BKOTHBNX2DY - Days enrollment to F33 Broken Other Bone

Col 35

N	Missing	Min	Max	Mean	StdDev
2,319	19,997	4,712	11,126	7,342.728	1,511.366

F33ANYFXNONHIP - F33 Any Non-Hip Fracture

Col 36

Any fracture except hip (includes other bone).

Usage Notes:

F33ANYFXNONHIP is 1 if the participant has a first event for any of the individual fracture outcomes during Ext 2

Value	Description	N	%
0	No	15,417	69.1
1	Yes	6,899	30.9

F33ANYFXNONHIPDY - Days enrollment to F33 Any Non-Hip Fracture

Col 37

N	Missing	Min	Max	Mean	StdDev
6,899	15,417	4,655	11,126	7,187.902	1,504.8

F33HYST - F33 Hysterectomy Ever

Col 38

Value	Description	N	%
0	No	21,610	96.8
1	Yes	706	3.2

F33HYSTDY - Days enrollment to F33 Hysterectomy Ever

Col 39

N	Missing	Min	Max	Mean	StdDev
706	21,610	4,739	10,718	7,013.419	1,377.593

F33OSTEOAR - F33 Osteoarthritis

Col 40

Usage Notes:

Not collected on all versions of F33.

Value	Description	N	%
0	No	16,144	72.3
1	Yes	6,172	27.7

F33OSTEOARDY - Days enrollment to F33 Osteoarthritis

Col 41

N	Missing	Min	Max	Mean	StdDev
6,172	16,144	4,416	11,299	7,218.687	1,433.124

F33INTPOLYP - F33 Intestinal Polyps

Col 42

Value	Description	N	%
0	No	19,900	89.2
1	Yes	2,416	10.8

F33INTPOLYPDY - Days enrollment to F33 Intestinal Polyps

Col 43

N	Missing	Min	Max	Mean	StdDev
2,416	19,900	4,533	11,101	6,857.927	1,364.758

F33LUPUS - F33 Lupus

Col 44

Value	Description	N	%
0	No	22,184	99.4
1	Yes	132	0.6

F33LUPUSDY - Days enrollment to F33 Lupus

Col 45

N	Missing	Min	Max	Mean	StdDev
132	22,184	4,788	9,136	6,625.962	1,043.548

F33PILLSHYP - F33 Pills for Hypertension

Col 46

Value	Description	N	%
0	No	19,301	86.5
1	Yes	3,015	13.5

F33PILLSHYPDY - Days enrollment to F33 Pills For Hypertension

Col 47

N	Missing	Min	Max	Mean	StdDev
3,015	19,301	4,435	11,033	7,089.611	1,516.131

F33DIABTX - F33 Diabetes Treated

Col 48

Usage Notes:

Pills or insulin shots.

Value	Description	N	%
0	No	19,260	86.3
1	Yes	3,056	13.7

F33DIABTXDY - Days enrollment to F33 Diabetes Treated

Col 49

N	Missing	Min	Max	Mean	StdDev
3,056	19,260	4,469	11,044	7,394.861	1,566.575

F33DIABINSULIN - F33 Diabetes Insulin

Col 50

Value	Description	N	%
0	No	21,368	95.8
1	Yes	948	4.2

F33DIABINSULINDY - Days enrollment to F33 Diabetes Insulin

Col 51

N	Missing	Min	Max	Mean	StdDev
948	21,368	4,567	10,975	7,341.761	1,505.735

F33DIABPILLS - F33 Diabetes Pills

Col 52

Value	Description	N	%
0	No	19,313	86.5
1	Yes	3,003	13.5

F33DIABPILLSDY - Days enrollment to F33 Diabetes Pills

Col 53

N	Missing	Min	Max	Mean	StdDev
3,003	19,313	4,469	11,044	7,416.947	1,568.006

F33DIABDIEX - F33 Diabetes Diet and/or Exercise

Col 54

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	18,360	82.3
1	Yes	3,956	17.7

F33DIABDIEXDY - Days enrollment to Diabetes Diet and/or Exercise

Col 55

N	Missing	Min	Max	Mean	StdDev
3,956	18,360	4,446	11,114	7,128.38	1,450.355

F33PARKINSONS - F33 Parkinsons

Col 56

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	21,861	98
1	Yes	455	2

F33PARKINSONSDY - Days enrollment to F33 Parkinsons

Col 57

N	Missing	Min	Max	Mean	StdDev
455	21,861	4,668	10,946	7,590.785	1,513.825

F33ALZHEIMERS - F33 Moderate or severe memory problems, dementia or Alzheimers

Col 58

Moderate or severe memory problems, dementia or Alzheimers

Usage Notes:

For version 13 of Form 33, this is a 1 if either “Moderate or severe memory problems” or “Dementia or Alzheimer’s” questions are marked. Prior to version 13 this was a single question "Moderate or severe memory problems (dementia or Alzheimers)"

Value	Description	N	%
0	No	16,600	74.4
1	Yes	5,716	25.6

F33ALZHEIMERSDY - Days enrollment to F33 Alzheimers

Col 59

N	Missing	Min	Max	Mean	StdDev
5,716	16,600	4,469	11,147	8,018.051	1,491.049

F33MACDEGEN - F33 Macular Degeneration

Col 60

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	17,904	80.2
1	Yes	4,412	19.8

F33MACDEGENDY - Days enrollment to F33 Macular Degeneration

Col 61

N	Missing	Min	Max	Mean	StdDev
4,412	17,904	4,469	11,284	7,434.988	1,468.941

LAST33DY - Days enrollment to last form 33/33D

Col 62

Days from enrollment to last contact for outcomes information.

Usage Notes:

LAST33DY is calculated as the days from enrollment to the latest Form 33 during Extension Study 2. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33DY. LAST33DY may be missing if the ppt had no form 33s entered for extension 2.

N	Missing	Min	Max	Mean	StdDev
22,121	195	4,351	11,375	8,847.502	1,586.115

F33HOSPX2 - F33 Hospitalized During Extension Study 2

Col 63

Value	Description	N	%
0	No	6,701	30
1	Yes	15,615	70

F33HOSPTIMESX2 - F33 Number of Hospitalizations During Extension Study 2

Col 64

Value	Description	N	%
0	None	6,701	30
1	One	5,016	22.5
2	Two	3,707	16.6
3	Three or more	6,892	30.9