This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Self-Reported Outcomes, Extension Study 2, MRC Participants

File Name	Data as of	Population	Data collected	One row per	Rows
outc_self_x2_mrc_inv.dat	2/17/2024	MRC	Ext2	Participant	22,316

A self report is only counted if the first report of that outcome occurred after the start of the extension 2 phase of the study.

ID - WHI Participant Common ID

Col 1

N	Missing	Min	Max	Mean	StdDev
22,316	0	100,004	299,997	200,492.7	57,496.836

F33ANGHOSP - F33 Hospitalized Angina

Col 2

Value	Description	N	%
0	No	20,366	91.3
1	Yes	1,950	8.7

F33ANGHOSPDY - Days enrollment to F33 Hospitalized Angina

Col 3

N	Missing	Min	Max	Mean	StdDev
1,950	20,366	4,718	10,710	7,102.268	1,405.933

F33COPD - F33 COPD

Col 4

COPD, emphysema, or chronic bronchitis

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	18,960	85
1	Yes	3,356	15

F33COPDDY - Days enrollment to F33 COPD

Col 5

N	Missing	Min	Max	Mean	StdDev
3,356	18,960	4,469	10,863	7,030.566	1,341.738

F33AFIBHSP - F33 Hospitalized Atrial Fibrillation

Col 6

Usage Notes:

Only collected during the WHI Extension Study 2

Value	Description	N	%
0	No	19,774	88.6
1	Yes	2,542	11.4

F33AFIBHSPDY - Days enrollment to F33 Hospitalized Atrial Fibrillation

Col 7

N	Missing	Min	Max	Mean	StdDev
2,542	19,774	4,469	10,703	6,940.43	1,320.868

F33AFIBOP - F33 Outpatient Atrial Fibrillation

Col 8

Value	Description	N	%
0	No	20,565	92.2
1	Yes	1,751	7.8

F33AFIBOPDY - Days enrollment to F33 Outpatient Atrial Fibrillation

Col 9

N	Missing	Min	Max	Mean	StdDev
1,751	20,565	4,515	10,710	7,329.826	1,328.793

F33NMSC - Non-Melanoma Skin Cancer

Col 10

Value	Description	N	%
0	No	21,462	96.2
1	Yes	854	3.8

F33NMSCDY - Days enrollment to F33 Non-Melanoma Skin Cancer

Col 11

N	Missing	Min	Max	Mean	StdDev
854	21,462	4,742	10,737	7,869.759	1,464.455

F33BKULEG - F33 Broken Upper Leg

Col 12

Value	Description	N	%
0	No	21,714	97.3
1	Yes	602	2.7

F33BKULEGDY - Days enrollment to F33 Broken Upper Leg

Col 13

N	Missing	Min	Max	Mean	StdDev
602	21,714	4,725	10,712	7,700.012	1,475.082

F33BKPELV - F33 Broken Pelvis

Col 14

Value	Description	N	%
0	No	21,708	97.3
1	Yes	608	2.7

F33BKPELVDY - Days enrollment to F33 Broken Pelvis

Col 15

N	Missing	Min	Max	Mean	StdDev
608	21,708	4,748	10,863	7,533.898	1,465.633

F33BKKNEE - F33 Broken Knee

Col 16

Value	Description	N	%
0	No	21,825	97.8
1	Yes	491	2.2

F33BKKNEEDY - Days enrollment to F33 Broken Knee

Col 17

N	Missing	Min	Max	Mean	StdDev
491	21,825	4,738	10,750	7,175.619	1,441.691

F33BKSPINE - F33 Broken Spine

Col 18

Value	Description	N	%
0	No	21,216	95.1
1	Yes	1,100	4.9

F33BKSPINEDY - Days enrollment to F33 Broken Spine

Col 19

N	Missing	Min	Max	Mean	StdDev
1,100	21,216	4,717	10,886	7,344.711	1,458.401

F33BKUARM - F33 Broken Upper Arm

Col 20

Value	Description	N	%
0	No	21,225	95.1
1	Yes	1,091	4.9

F33BKUARMDY - Days enrollment to F33 Broken Upper Arm

Col 21

N	Missing	Min	Max	Mean	StdDev
1,091	21,225	4,669	10,780	7,399.151	1,458.334

F33BKLARM - F33 Broken Lower Arm

Col 22

Value	Description	N	%
0	No	21,064	94.4
1	Yes	1,252	5.6

F33BKLARMDY - Days enrollment to F33 Broken Lower Arm

Col 23

N	Missing	Min	Max	Mean	StdDev
1,252	21,064	4,655	10,864	7,189.246	1,466.521

F33BKHAND - F33 Broken Hand

Col 24

Value	Description	N	%
0	No	22,028	98.7
1	Yes	288	1.3

F33BKHANDDY - Days enrollment to F33 Broken Hand

Col 25

N	Missing	Min	Max	Mean	StdDev
288	22,028	4,760	10,245	7,179.938	1,401.611

F33BKLLEG - F33 Broken Lower Leg

Col 26

Value	Description	N	%
0	No	21,521	96.4
1	Yes	795	3.6

F33BKLLEGDY - Days enrollment to F33 Broken Lower Leg

Col 27

N	Missing	Min	Max	Mean	StdDev
795	21,521	4,727	10,768	7,169.541	1,432.979

F33BKFOOT - F33 Broken Foot

Col 28

Value	Description	N	%
0	No	21,727	97.4
1	Yes	589	2.6

F33BKFOOTDY - Days enrollment to F33 Broken Foot

Col 29

N	Missing	Min	Max	Mean	StdDev
589	21,727	4,732	10,886	7,070.844	1,418.079

F33BKTAILBN - F33 Broken Tailbone

Col 30

Value	Description	N	%
0	No	22,127	99.2
1	Yes	189	0.8

F33BKTAILBNDY - Days enrollment to F33 Broken Tailbone

Col 31

N	Missing	Min	Max	Mean	StdDev
189	22,127	4,752	10,465	7,515.899	1,416.841

F33BKELBOW - F33 Broken Elbow

Col 32

Value	Description	N	%
0	No	22,053	98.8
1	Yes	263	1.2

F33BKELBOWDY - Days enrollment to F33 Broken Elbow

Col 33

N	Missing	Min	Max	Mean	StdDev
263	22,053	4,655	10,465	7,227.407	1,411.486

F33BKOTHBNX2 - F33 Broken Other Bone

Col 34

Broken other bone, Extension 2 definition.

Usage Notes:

This variable does not map to the Broken Other Bone (F33BKOTHBN) variable collected prior to Extension Study 2, as the form question changed.

Value	Description	N	%
0	No	20,095	90
1	Yes	2,221	10

F33BKOTHBNX2DY - Days enrollment to F33 Broken Other Bone

Col 35

N	Missing	Min	Max	Mean	StdDev
2,221	20,095	4,712	10,912	7,219.4	1,420.471

F33ANYFXNONHIP - F33 Any Non-Hip Fracture

Col 36

Any fracture except hip (includes other bone).

Usage Notes:

F33ANYFXNONHIP is 1 if the participant has a first event for any of the individual fracture outcomes during Ext 2

Value	Description	N	%
0	No	15,653	70.1
1	Yes	6,663	29.9

F33ANYFXNONHIPDY - Days enrollment to F33 Any Non-Hip Fracture

Col 37

N	Missing	Min	Max	Mean	StdDev
6,663	15,653	4,655	10,886	7,084.158	1,422.828

F33HYST - F33 Hysterectomy Ever

Col 38

Value	Description	N	%
0	No	21,622	96.9
1	Yes	694	3.1

F33HYSTDY - Days enrollment to F33 Hysterectomy Ever

Col 39

N	Missing	Min	Max	Mean	StdDev
694	21,622	4,739	10,504	6,960.382	1,327.626

F33OSTEOAR - F33 Osteoarthritis

Col 40

Usage Notes:

Not collected on all versions of F33.

Value	Description	N	%
0	No	16,308	73.1
1	Yes	6,008	26.9

F33OSTEOARDY - Days enrollment to F33 Osteoarthritis

Col 41

N	Missing	Min	Max	Mean	StdDev
6,008	16,308	4,416	10,788	7,139.574	1,366.547

F33INTPOLYP - F33 Intestinal Polyps

Col 42

Value	Description	N	%
0	No	19,936	89.3
1	Yes	2,380	10.7

F33INTPOLYPDY - Days enrollment to F33 Intestinal Polyps

Col 43

N	Missing	Min	Max	Mean	StdDev
2,380	19,936	4,533	10,915	6,808.17	1,312.296

F33LUPUS - F33 Lupus

Col 44

Value	Description	N	%
0	No	22,184	99.4
1	Yes	132	0.6

F33LUPUSDY - Days enrollment to F33 Lupus

Col 45

N	Missing	Min	Max	Mean	StdDev
132	22,184	4,788	9,136	6,625.962	1,043.548

F33PILLSHYP - F33 Pills for Hypertension

Col 46

Value	Description	N	%
0	No	19,397	86.9
1	Yes	2,919	13.1

F33PILLSHYPDY - Days enrollment to F33 Pills For Hypertension

Col 47

N	Missing	Min	Max	Mean	StdDev
2,919	19,397	4,435	10,760	6,987.984	1,429.769

F33DIABTX - F33 Diabetes Treated

Col 48

Usage Notes:

Pills or insulin shots.

Value	Description	N	%
0	No	19,401	86.9
1	Yes	2,915	13.1

F33DIABTXDY - Days enrollment to F33 Diabetes Treated

Col 49

N	Missing	Min	Max	Mean	StdDev
2,915	19,401	4,469	10,954	7,261.398	1,476.215

F33DIABINSULIN - F33 Diabetes Insulin

Col 50

Value	Description	N	%
0	No	21,405	95.9
1	Yes	911	4.1

F33DIABINSULINDY - Days enrollment to F33 Diabetes Insulin

Col 51

N	Missing	Min	Max	Mean	StdDev
911	21,405	4,567	10,562	7,225.823	1,416.748

F33DIABPILLS - F33 Diabetes Pills

Col 52

Value	Description	N	%
0	No	19,453	87.2
1	Yes	2,863	12.8

F33DIABPILLSDY - Days enrollment to F33 Diabetes Pills

Col 53

N	Missing	Min	Max	Mean	StdDev
2,863	19,453	4,469	10,954	7,282.796	1,478.263

F33DIABDIEX - F33 Diabetes Diet and/or Exercise

Col 54

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	18,463	82.7
1	Yes	3,853	17.3

F33DIABDIEXDY - Days enrollment to Diabetes Diet and/or Exercise

Col 55

N	Missing	Min	Max	Mean	StdDev
3,853	18,463	4,446	10,719	7,048.54	1,382.199

F33PARKINSONS - F33 Parkinsons

Col 56

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	21,884	98.1
1	Yes	432	1.9

F33PARKINSONSDY - Days enrollment to F33 Parkinsons

Col 57

N	Missing	Min	Max	Mean	StdDev
432	21,884	4,668	10,611	7,452.28	1,423.362

F33ALZHEIMERS - F33 Moderate or severe memory problems, dementia or Alzheimers

Col 58

Moderate or severe memory problems, dementia or Alzheimers

Usage Notes:

For version 13 of Form 33, this is a 1 if either “Moderate or severe memory problems” or “Dementia or Alzheimer’s” questions are marked. Prior to version 13 this was a single question "Moderate or severe memory problems (dementia or Alzheimers)"

Value	Description	N	%
0	No	16,978	76.1
1	Yes	5,338	23.9

F33ALZHEIMERSDY - Days enrollment to F33 Alzheimers

Col 59

N	Missing	Min	Max	Mean	StdDev
5,338	16,978	4,469	10,868	7,866.634	1,421.609

F33MACDEGEN - F33 Macular Degeneration

Col 60

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	18,069	81
1	Yes	4,247	19

F33MACDEGENDY - Days enrollment to F33 Macular Degeneration

Col 61

N	Missing	Min	Max	Mean	StdDev
4,247	18,069	4,469	10,780	7,328.662	1,389.929

LAST33DY - Days enrollment to last form 33/33D

Col 62

Days from enrollment to last contact for outcomes information.

Usage Notes:

LAST33DY is calculated as the days from enrollment to the latest Form 33 during Extension Study 2. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33DY. LAST33DY may be missing if the ppt had no form 33s entered for extension 2.

N	Missing	Min	Max	Mean	StdDev
22,119	197	4,351	11,031	8,674.986	1,458.514

F33HOSPX2 - F33 Hospitalized During Extension Study 2

Col 63

Value	Description	N	%
0	No	6,857	30.7
1	Yes	15,459	69.3

F33HOSPTIMESX2 - F33 Number of Hospitalizations During Extension Study 2

Col 64

Value	Description	N	%
0	None	6,857	30.7
1	One	5,020	22.5
2	Two	3,686	16.5
3	Three or more	6,753	30.3