This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Self-Reported Outcomes, Extension Study 2, MRC Participants

File Name	Data as of	Population	Data collected	One row per	Rows
outc_self_x2_mrc_inv.dat	2/19/2023	MRC	Ext2	Participant	22,316

A self report is only counted if the first report of that outcome occurred after the start of the extension 2 phase of the study.

ID - WHI Participant Common ID

Col 1

N	Missing	Min	Max	Mean	StdDev
22,316	0	100,004	299,997	200,492.7	57,496.836

F33ANGHOSP - F33 Hospitalized Angina

Col 2

Value	Description	N	%
0	No	20,458	91.7
1	Yes	1,858	8.3

F33ANGHOSPDY - Days enrollment to F33 Hospitalized Angina

Col 3

N	Missing	Min	Max	Mean	StdDev
1,858	20,458	4,718	10,563	6,967.503	1,296.05

F33COPD - F33 COPD

Col 4

COPD, emphysema, or chronic bronchitis

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	19,071	85.5
1	Yes	3,245	14.5

F33COPDDY - Days enrollment to F33 COPD

Col 5

N	Missing	Min	Max	Mean	StdDev
3,245	19,071	4,469	10,384	6,938.46	1,264.559

F33AFIBHSP - F33 Hospitalized Atrial Fibrillation

Col 6

Usage Notes:

Only collected during the WHI Extension Study 2

Value	Description	N	%
0	No	19,861	89
1	Yes	2,455	11

F33AFIBHSPDY - Days enrollment to F33 Hospitalized Atrial Fibrillation

Col 7

N	Missing	Min	Max	Mean	StdDev
2,455	19,861	4,469	10,359	6,841.694	1,231.011

F33AFIBOP - F33 Outpatient Atrial Fibrillation

Col 8

Value	Description	N	%
0	No	20,628	92.4
1	Yes	1,688	7.6

F33AFIBOPDY - Days enrollment to F33 Outpatient Atrial Fibrillation

Col 9

N	Missing	Min	Max	Mean	StdDev
1,688	20,628	4,515	10,352	7,238.671	1,262.811

F33NMSC - Non-Melanoma Skin Cancer

Col 10

Value	Description	N	%
0	No	21,543	96.5
1	Yes	773	3.5

F33NMSCDY - Days enrollment to F33 Non-Melanoma Skin Cancer

Col 11

N	Missing	Min	Max	Mean	StdDev
773	21,543	4,742	10,230	7,668.182	1,387.265

F33BKULEG - F33 Broken Upper Leg

Col 12

Value	Description	N	%
0	No	21,769	97.5
1	Yes	547	2.5

F33BKULEGDY - Days enrollment to F33 Broken Upper Leg

Col 13

N	Missing	Min	Max	Mean	StdDev
547	21,769	4,725	10,221	7,485.201	1,365.33

F33BKPELV - F33 Broken Pelvis

Col 14

Value	Description	N	%
0	No	21,746	97.4
1	Yes	570	2.6

F33BKPELVDY - Days enrollment to F33 Broken Pelvis

Col 15

N	Missing	Min	Max	Mean	StdDev
570	21,746	4,748	10,401	7,377.607	1,373.54

F33BKKNEE - F33 Broken Knee

Col 16

Value	Description	N	%
0	No	21,855	97.9
1	Yes	461	2.1

F33BKKNEEDY - Days enrollment to F33 Broken Knee

Col 17

N	Missing	Min	Max	Mean	StdDev
461	21,855	4,738	10,339	7,009.169	1,321.339

F33BKSPINE - F33 Broken Spine

Col 18

Value	Description	N	%
0	No	21,287	95.4
1	Yes	1,029	4.6

F33BKSPINEDY - Days enrollment to F33 Broken Spine

Col 19

N	Missing	Min	Max	Mean	StdDev
1,029	21,287	4,717	10,565	7,170.477	1,337.464

F33BKUARM - F33 Broken Upper Arm

Col 20

Value	Description	N	%
0	No	21,290	95.4
1	Yes	1,026	4.6

F33BKUARMDY - Days enrollment to F33 Broken Upper Arm

Col 21

N	Missing	Min	Max	Mean	StdDev
1,026	21,290	4,669	10,386	7,245.804	1,362.447

F33BKLARM - F33 Broken Lower Arm

Col 22

Value	Description	N	%
0	No	21,135	94.7
1	Yes	1,181	5.3

F33BKLARMDY - Days enrollment to F33 Broken Lower Arm

Col 23

N	Missing	Min	Max	Mean	StdDev
1,181	21,135	4,655	10,401	7,032.273	1,353.749

F33BKHAND - F33 Broken Hand

Col 24

Value	Description	N	%
0	No	22,038	98.8
1	Yes	278	1.2

F33BKHANDDY - Days enrollment to F33 Broken Hand

Col 25

N	Missing	Min	Max	Mean	StdDev
278	22,038	4,760	10,245	7,085.266	1,331.213

F33BKLLEG - F33 Broken Lower Leg

Col 26

Value	Description	N	%
0	No	21,558	96.6
1	Yes	758	3.4

F33BKLLEGDY - Days enrollment to F33 Broken Lower Leg

Col 27

N	Missing	Min	Max	Mean	StdDev
758	21,558	4,727	10,213	7,039.017	1,332.133

F33BKFOOT - F33 Broken Foot

Col 28

Value	Description	N	%
0	No	21,753	97.5
1	Yes	563	2.5

F33BKFOOTDY - Days enrollment to F33 Broken Foot

Col 29

N	Missing	Min	Max	Mean	StdDev
563	21,753	4,732	9,946	6,945.258	1,318.864

F33BKTAILBN - F33 Broken Tailbone

Col 30

Value	Description	N	%
0	No	22,133	99.2
1	Yes	183	0.8

F33BKTAILBNDY - Days enrollment to F33 Broken Tailbone

Col 31

N	Missing	Min	Max	Mean	StdDev
183	22,133	4,752	10,223	7,439.503	1,371.948

F33BKELBOW - F33 Broken Elbow

Col 32

Value	Description	N	%
0	No	22,068	98.9
1	Yes	248	1.1

F33BKELBOWDY - Days enrollment to F33 Broken Elbow

Col 33

N	Missing	Min	Max	Mean	StdDev
248	22,068	4,655	10,127	7,079.645	1,310.919

F33BKOTHBNX2 - F33 Broken Other Bone

Col 34

Broken other bone, Extension 2 definition.

Usage Notes:

This variable does not map to the Broken Other Bone (F33BKOTHBN) variable collected prior to Extension Study 2, as the form question changed.

Value	Description	N	%
0	No	20,215	90.6
1	Yes	2,101	9.4

F33BKOTHBNX2DY - Days enrollment to F33 Broken Other Bone

Col 35

N	Missing	Min	Max	Mean	StdDev
2,101	20,215	4,712	10,565	7,074.179	1,315.571

F33ANYFXNONHIP - F33 Any Non-Hip Fracture

Col 36

Any fracture except hip (includes other bone).

Usage Notes:

F33ANYFXNONHIP is 1 if the participant has a first event for any of the individual fracture outcomes during Ext 2

Value	Description	N	%
0	No	15,954	71.5
1	Yes	6,362	28.5

F33ANYFXNONHIPDY - Days enrollment to F33 Any Non-Hip Fracture

Col 37

N	Missing	Min	Max	Mean	StdDev
6,362	15,954	4,655	10,516	6,954.705	1,318.977

F33HYST - F33 Hysterectomy Ever

Col 38

Value	Description	N	%
0	No	21,643	97
1	Yes	673	3

F33HYSTDY - Days enrollment to F33 Hysterectomy Ever

Col 39

N	Missing	Min	Max	Mean	StdDev
673	21,643	4,739	10,332	6,873.966	1,251.459

F33OSTEOAR - F33 Osteoarthritis

Col 40

Usage Notes:

Not collected on all versions of F33.

Value	Description	N	%
0	No	16,532	74.1
1	Yes	5,784	25.9

F33OSTEOARDY - Days enrollment to F33 Osteoarthritis

Col 41

N	Missing	Min	Max	Mean	StdDev
5,784	16,532	4,416	10,456	7,035.913	1,283.262

F33INTPOLYP - F33 Intestinal Polyps

Col 42

Value	Description	N	%
0	No	19,991	89.6
1	Yes	2,325	10.4

F33INTPOLYPDY - Days enrollment to F33 Intestinal Polyps

Col 43

N	Missing	Min	Max	Mean	StdDev
2,325	19,991	4,533	10,195	6,738.173	1,243.682

F33LUPUS - F33 Lupus

Col 44

Value	Description	N	%
0	No	22,184	99.4
1	Yes	132	0.6

F33LUPUSDY - Days enrollment to F33 Lupus

Col 45

N	Missing	Min	Max	Mean	StdDev
132	22,184	4,788	9,136	6,625.962	1,043.548

F33PILLSHYP - F33 Pills for Hypertension

Col 46

Value	Description	N	%
0	No	19,509	87.4
1	Yes	2,807	12.6

F33PILLSHYPDY - Days enrollment to F33 Pills For Hypertension

Col 47

N	Missing	Min	Max	Mean	StdDev
2,807	19,509	4,435	10,516	6,877.969	1,342.894

F33DIABTX - F33 Diabetes Treated

Col 48

Usage Notes:

Pills or insulin shots.

Value	Description	N	%
0	No	19,552	87.6
1	Yes	2,764	12.4

F33DIABTXDY - Days enrollment to F33 Diabetes Treated

Col 49

N	Missing	Min	Max	Mean	StdDev
2,764	19,552	4,469	10,362	7,124.573	1,388.926

F33DIABINSULIN - F33 Diabetes Insulin

Col 50

Value	Description	N	%
0	No	21,444	96.1
1	Yes	872	3.9

F33DIABINSULINDY - Days enrollment to F33 Diabetes Insulin

Col 51

N	Missing	Min	Max	Mean	StdDev
872	21,444	4,567	10,498	7,116.251	1,345.472

F33DIABPILLS - F33 Diabetes Pills

Col 52

Value	Description	N	%
0	No	19,606	87.9
1	Yes	2,710	12.1

F33DIABPILLSDY - Days enrollment to F33 Diabetes Pills

Col 53

N	Missing	Min	Max	Mean	StdDev
2,710	19,606	4,469	10,339	7,142.572	1,390.149

F33DIABDIEX - F33 Diabetes Diet and/or Exercise

Col 54

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	18,587	83.3
1	Yes	3,729	16.7

F33DIABDIEXDY - Days enrollment to Diabetes Diet and/or Exercise

Col 55

N	Missing	Min	Max	Mean	StdDev
3,729	18,587	4,446	10,357	6,959.186	1,311.862

F33PARKINSONS - F33 Parkinsons

Col 56

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	21,916	98.2
1	Yes	400	1.8

F33PARKINSONSDY - Days enrollment to F33 Parkinsons

Col 57

N	Missing	Min	Max	Mean	StdDev
400	21,916	4,668	10,198	7,260.428	1,295.489

F33ALZHEIMERS - F33 Moderate or severe memory problems, dementia or Alzheimers

Col 58

Moderate or severe memory problems, dementia or Alzheimers

Usage Notes:

For version 13 of Form 33, this is a 1 if either “Moderate or severe memory problems” or “Dementia or Alzheimer’s” questions are marked. Prior to version 13 this was a single question "Moderate or severe memory problems (dementia or Alzheimers)"

Value	Description	N	%
0	No	17,476	78.3
1	Yes	4,840	21.7

F33ALZHEIMERSDY - Days enrollment to F33 Alzheimers

Col 59

N	Missing	Min	Max	Mean	StdDev
4,840	17,476	4,469	10,415	7,674	1,346.515

F33MACDEGEN - F33 Macular Degeneration

Col 60

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	18,277	81.9
1	Yes	4,039	18.1

F33MACDEGENDY - Days enrollment to F33 Macular Degeneration

Col 61

N	Missing	Min	Max	Mean	StdDev
4,039	18,277	4,469	10,403	7,205.21	1,308.115

LAST33DY - Days enrollment to last form 33/33D

Col 62

Days from enrollment to last contact for outcomes information.

Usage Notes:

LAST33DY is calculated as the days from enrollment to the latest Form 33 during Extension Study 2. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33DY. LAST33DY may be missing if the ppt had no form 33s entered for extension 2.

N	Missing	Min	Max	Mean	StdDev
22,120	196	4,351	10,608	8,482.994	1,327.179

F33HOSPX2 - F33 Hospitalized During Extension Study 2

Col 63

Value	Description	N	%
0	No	7,031	31.5
1	Yes	15,285	68.5

F33HOSPTIMESX2 - F33 Number of Hospitalizations During Extension Study 2

Col 64

Value	Description	N	%
0	None	7,031	31.5
1	One	5,025	22.5
2	Two	3,669	16.4
3	Three or more	6,591	29.5