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Stroke/Carotid Artery Disease Outcome Details (Form 121/132)

File NameData as ofPopulationData collectedOne row perRows
outc_strk_carotid_inv.dat5/10/2026CT+OSMain, Ext1, Ext2Outcome Form12,071

In Ext2 stroke outcomes are adjudicated for all participants; carotid artery disease outcomes are only adjudicated for Medical Report Cohort (MRC) participants.

ID - WHI Participant Common ID
Col 1
NMissing
12,0710
ASCSOURCE - Ascertainment Source
Col 2
ValueDescriptionN%
1Local Form 1211,1129.2
2Central Form 1213993.3
3Central Form 13210,56087.5
CAROTID - Carotid Artery Disease
Col 3
Usage Notes:

Carotid Artery Disease was adjudicated for CT and OS participants through Ext1. In Ext2 It is only adjudicated for the Medical Record Cohort. Carotid Artery Disease occurring on or after a Stroke is not counted.

ValueDescriptionN%
0No00
1Yes1,66513.8
Missing10,40686.2%
STRKHEMO - Hemorrhagic Stroke
Col 4
Usage Notes:

Defined as a Stroke where the diagnosis question indicates a hemorrhagic stroke. With the completion of retrospective adjudications for stroke cases among Self Report Cohort (SRC) participants, hemorrhagic stroke is now adjudicated for all CT and OS participants through Ext2. Strokes from cause of death, Form 121 and early versions of 132 were not able to determine Hemorrhagic/Ischemic classification. Includes inpatient strokes for the core WHI study and inpatient and outpatient strokes after the core study closeout.

ValueDescriptionN%
0No00
1Yes1,40611.6
Missing10,66588.4%
STRKISCH - Ischemic Stroke
Col 5
Usage Notes:

Defined as a Stroke where the diagnosis question indicates an iscemic stroke. With the completion of retrospective adjudications for stroke cases among Self Report Cohort (SRC) participants, ischemic stroke is now adjudicated for all CT and OS participants through Ext2. Strokes from cause of death, Form 121 and early versions of 132 were not able to determine Hemorrhagic/Ischemic classification. Includes inpatient strokes for the core WHI study and inpatient and outpatient strokes after the core study closeout.

ValueDescriptionN%
0No00
1Yes8,94674.1
Missing3,12525.9%
STROKE - Stroke
Col 6
Usage Notes:

Defined as the first occurrence of Stroke or a Death due to Cerebrovascular. With the completion of retrospective adjudications for stroke cases among Self Report Cohort (SRC) participants, stroke is now adjudicated for all CT and OS participants through Ext2. In order to be able to classify strokes, WHI uses central adjudications where available. See the DEATH and DEATHSRC variables for details about the death adjudication process. Includes inpatient strokes for the core WHI study and inpatient and outpatient strokes after the core study closeout.

ValueDescriptionN%
0No00
1Yes10,40886.2
Missing1,66313.8%
STROKEDX - Stroke diagnosis
Col 7
Usage Notes:

Value 6 was only on form 121 and early versions of form 132. Strokes with a diagnosis code of 6 were unable to be classified as Hemorrhagic or Ischemic.

ValueDescriptionN%
1Subarachnoid hemorrhage2642.2
2Intraparenchymal hemorrhage1,1079.2
3Other or unspec intracranial hemorrhage350.3
4Occlusion of cerebral arteries w/infarction8,94674.1
5Acute but ill-defined cerebrovascular disease550.5
6Central nervous system complications during/from procedure00
Missing1,66413.8%
STROKEPROC - Stroke occurred during or resulted from a procedure
Col 8
Usage Notes:

Not collected on early versions of F132. A stroke is defined as procedure-related if it occurs within 24 hours after any procedure or within 30 days after a cardioversion or invasive cardiovascular procedure.

ValueDescriptionN%
0No9,56879.3
1Yes5154.3
9Unknown440.4
Missing1,94416.1%
STROKEOUTPAT - F132 Stroke diagnosed or managed as outpatient
Col 9

Was the stroke diagnosed or managed as an outpatient?* *The outpatient setting includes any emergency department or observation unit, short hospital stays of less than 24 hours duration or a direct admission to a rehab facility without an associated admission to an acute care hospital.

Usage Notes:

Only collected after WHI closeout.

ValueDescriptionN%
0No7,93965.8
1Yes3983.3
Missing3,73430.9%
STROKEOXFORD - Oxfordshire Classification
Col 10
ValueDescriptionN%
1Total Anterior Circulation Infarction (TACI )5314.4
2Partial Anterior Circulation Infarction (PACI)4,42136.6
3Lacunar Infarction (LACI)2,29819
4Posterior Circulation Infarction (POCI)1,50812.5
Missing3,31327.4%
STROKETOAST - TOAST Classification
Col 11

Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification

Usage Notes:

A "probable" diagnosis is made if the clinical findings, neuroimaging data, and results of diagnostic studies are consistent with one subtype and other etiologies have been excluded. A "possible" diagnosis is made when the clinical findings and neuroimaging data suggest a specific subtype but other studies are not done.

ValueDescriptionN%
1Probable large artery atherosclerosis4663.9
2Probable cardioembolism2,39119.8
3Probable small vessel occlusion (lacune)1,1379.4
4Probable stroke of other determined etiology1961.6
5Possible large artery atherosclerosis1381.1
6Possible cardioembolism5995
7Possible small vessel occlusion (lacune)4063.4
10Possible Stroke of other determined etiology780.6
11Stroke undetermined two or more causes identified9117.5
12Stroke undetermind negative evaluation1,43611.9
13Stroke undetermined incomplete evaluation1,1489.5
Missing3,16526.2%
STROKEBASE - Stroke diagnosis based on
Col 12
ValueDescriptionN%
1Rapid neuro deficit & CT/MRI lesion & w/o evid. of blood7,51662.3
2Rapid neuro deficit duration >= 24 hrs & rad n/a930.8
3Rapid neuro deficit duration >= 24hrs & rad early no acute9808.1
4Surgical evidence of ischemic infarction10
5CT or MRI blood hemor. in subarachnoid or intra-parenchymal1,32010.9
6Positive lumbar puncture40
7Surgical evidence of hemorrhage40
8None of the above4864
Missing1,66713.8%
STROKE28DEATH - Hospitalized stroke within 28 days of death
Col 13

If stroke fatal: Hospitalized stroke within 28 days of death

ValueDescriptionN%
0No510.4
1Yes8376.9
Missing11,18392.6%
STROKEPREV - Previous stroke and no other lethal disease
Col 14

If stroke fatal: Previous stroke and no known potentially lethal non-cerebrovascular disease process

ValueDescriptionN%
0No8617.1
1Yes270.2
Missing11,18392.6%
STROKEPOSTMORT - Stroke diagnosed at post-mortem
Col 15

If stroke fatal: Stroke diagnosed as cause of death at post-mortem examination

ValueDescriptionN%
0No8356.9
1Yes530.4
Missing11,18392.6%
STROKEDEATHCERT - Stroke listed on death certificate
Col 16

If stroke fatal: Stroke listed as underlying cause of death on death certificate

ValueDescriptionN%
0No2432
1Yes6445.3
Missing11,18492.7%
STROKEGLASGOW - Glasgow stroke outcome scale
Col 17

Participant’s functional status at the time of discharge (Glasgow Outcome Scale)

ValueDescriptionN%
1Good recovery3,22226.7
2Moderately disabled2,76822.9
3Severely disabled3,24626.9
4Vegetative survival720.6
5Deceased8256.8
6Unable to assign category2492.1
Missing1,68914%
CARDX - Carotid artery disease diagnosis
Col 18
Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
1Occlusion/stenosis w/o documentation of cerebral infarction1,55412.9
2Occlusion/stenosis w documentation of cerebral infarcation890.7
Missing10,42886.4%
CARBHOSP - Carotid artery disease based on hosp discharge
Col 19

Carotid artery disease based on: Symptomatic disease with carotid artery disease listed on the hospital discharge summary

Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
0No1,0508.7
1Yes5934.9
Missing10,42886.4%
CARBABNORMAL - Carotid artery disease based on abnormal findings
Col 20

Carotid artery disease based on: Symptomatic disease with abnormal findings (>= 50% stenosis) on carotid angiogram, MRA, or Doppler flow study

Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
0No9067.5
1Yes7376.1
Missing10,42886.4%
CARBPROC - Carotid artery disease based on vasc/surg proc.
Col 21

Carotid artery disease based on: Vascular or surgical procedure to improve flow to the ipsilateral brain.

Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
0No2562.1
1Yes1,38711.5
Missing10,42886.4%