This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Stroke/Carotid Artery Disease Outcome Details (Form 121/132), CaD ppts

File NameData as ofPopulationData collectedOne row perRows
outc_strk_carotid_cad_inv.dat2/17/2024CaDMain, Ext1Outcome Form1,622

This file contains outcomes collected through the end of Ext1.

ID - WHI Participant Common ID
Col 1
NMissing
1,6220
ASCSOURCE - Ascertainment Source
Col 2
ValueDescriptionN%
1Local Form 12124114.9
2Central Form 1211126.9
3Central Form 1321,26978.2
CAROTID - Carotid Artery Disease
Col 3
Usage Notes:

Carotid Artery Disease was adjudicated for CT and OS participants through Ext1. Carotid Artery Disease occurring on or after a Stroke is not counted.

ValueDescriptionN%
0No00
1Yes35822.1
Missing1,26477.9%
STRKHEMO - Hemorrhagic Stroke
Col 4
Usage Notes:

Defined as a Stroke where the diagnosis question indicates a hemorrhagic stroke. Hemorrhagic Stroke is adjudicated for CT and OS participants. Form 121 and early versions of 132 were not able to record Hemorrhagic/Ischemic classification for procedure related Strokes. See the Stroke Diagnosis variable for more detail.

ValueDescriptionN%
0No00
1Yes19311.9
Missing1,42988.1%
STRKISCH - Ischemic Stroke
Col 5
Usage Notes:

Defined as a Stroke where the diagnosis question indicates an iscemic stroke. Ischemic Stroke is adjudicated for CT and OS participants. Form 121 and early versions of 132 were not able to record Hemorrhagic/Ischemic classification for procedure related Strokes. See the Stroke Diagnosis variable for more detail.

ValueDescriptionN%
0No00
1Yes1,06365.5
Missing55934.5%
STROKE - Stroke
Col 6
Usage Notes:

Defined as the first occurrence of Stroke or a Death due to Cerebrovascular. Stroke is adjudicated for CT and OS participants. In order to be able to classify strokes, WHI uses central adjudications if possible, even though Strokes were only fully centrally adjudicated in HT participants. This file does not include Strokes determined solely by the cause of death.

ValueDescriptionN%
0No00
1Yes1,26578
Missing35722%
STROKEDX - Stroke diagnosis
Col 7
Usage Notes:

Value 6 was only on form 121 and early versions of form 132. Strokes with a diagnosis code of 6 were unable to be classified as Hemorrhagic or Ischemic.

ValueDescriptionN%
1Subarachnoid hemorrhage442.7
2Intraparenchymal hemorrhage1469
3Other or unspec intracranial hemorrhage30.2
4Occlusion of cerebral arteries w/infarction1,06365.5
5Acute but ill-defined cerebrovascular disease80.5
6Central nervous system complications during/from procedure00
Missing35822.1%
STROKEPROC - Stroke occurred during or resulted from a procedure
Col 8
Usage Notes:

Not collected on early versions of F132. A stroke is defined as procedure-related if it occurs within 24 hours after any procedure or within 30 days after a cardioversion or invasive cardiovascular procedure.

ValueDescriptionN%
0No1,07166
1Yes674.1
9Unknown60.4
Missing47829.5%
STROKEOUTPAT - F132 Stroke diagnosed or managed as outpatient
Col 9

Was the stroke diagnosed or managed as an outpatient?* *The outpatient setting includes any emergency department or observation unit, short hospital stays of less than 24 hours duration or a direct admission to a rehab facility without an associated admission to an acute care hospital.

Usage Notes:

Only collected after WHI closeout.

ValueDescriptionN%
0No85852.9
1Yes382.3
Missing72644.8%
STROKEOXFORD - Oxfordshire Classification
Col 10
ValueDescriptionN%
1Total Anterior Circulation Infarction (TACI )593.6
2Partial Anterior Circulation Infarction (PACI)51031.4
3Lacunar Infarction (LACI)30018.5
4Posterior Circulation Infarction (POCI)18111.2
Missing57235.3%
STROKETOAST - TOAST Classification
Col 11

Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification

Usage Notes:

A "probable" diagnosis is made if the clinical findings, neuroimaging data, and results of diagnostic studies are consistent with one subtype and other etiologies have been excluded. A "possible" diagnosis is made when the clinical findings and neuroimaging data suggest a specific subtype but other studies are not done.

ValueDescriptionN%
1Probable large artery atherosclerosis654
2Probable cardioembolism21413.2
3Probable small vessel occlusion (lacune)1418.7
4Probable stroke of other determined etiology291.8
5Possible large artery atherosclerosis201.2
6Possible cardioembolism543.3
7Possible small vessel occlusion (lacune)563.5
10Possible Stroke of other determined etiology150.9
11Stroke undetermined two or more causes identified804.9
12Stroke undetermind negative evaluation21313.1
13Stroke undetermined incomplete evaluation16310
Missing57235.3%
STROKEBASE - Stroke diagnosis based on
Col 12
ValueDescriptionN%
1Rapid neuro deficit & CT/MRI lesion & w/o evid. of blood83151.2
2Rapid neuro deficit duration >= 24 hrs & rad n/a50.3
3Rapid neuro deficit duration >= 24hrs & rad early no acute16810.4
4Surgical evidence of ischemic infarction10.1
5CT or MRI blood hemor. in subarachnoid or intra-parenchymal18611.5
6Positive lumbar puncture00
7Surgical evidence of hemorrhage00
8None of the above734.5
Missing35822.1%
STROKE28DEATH - Hospitalized stroke within 28 days of death
Col 13

If stroke fatal: Hospitalized stroke within 28 days of death

ValueDescriptionN%
0No100.6
1Yes945.8
Missing1,51893.6%
STROKEPREV - Previous stroke and no other lethal disease
Col 14

If stroke fatal: Previous stroke and no known potentially lethal non-cerebrovascular disease process

ValueDescriptionN%
0No1036.4
1Yes10.1
Missing1,51893.6%
STROKEPOSTMORT - Stroke diagnosed at post-mortem
Col 15

If stroke fatal: Stroke diagnosed as cause of death at post-mortem examination

ValueDescriptionN%
0No1006.2
1Yes40.2
Missing1,51893.6%
STROKEDEATHCERT - Stroke listed on death certificate
Col 16

If stroke fatal: Stroke listed as underlying cause of death on death certificate

ValueDescriptionN%
0No211.3
1Yes835.1
Missing1,51893.6%
STROKEGLASGOW - Glascow stroke outcome scale
Col 17

Participant’s functional status at the time of discharge (Glasgow Outcome Scale)

ValueDescriptionN%
1Good recovery49030.2
2Moderately disabled31819.6
3Severely disabled29218
4Vegetative survival90.6
5Deceased996.1
6Unable to assign category493
Missing36522.5%
CARDX - Carotid artery disease diagnosis
Col 18
Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
1Occlusion/stenosis w/o documentation of cerebral infarction33820.8
2Occlusion/stenosis w documentation of cerebral infarcation171
Missing1,26778.1%
CARBHOSP - Carotid artery disease based on hosp discharge
Col 19

Carotid artery disease based on: Symptomatic disease with carotid artery disease listed on the hospital discharge summary

Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
0No22013.6
1Yes1338.2
Missing1,26978.2%
CARBABNORMAL - Carotid artery disease based on abnormal findings
Col 20

Carotid artery disease based on: Symptomatic disease with abnormal findings (>= 50% stenosis) on carotid angiogram, MRA, or Doppler flow study

Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
0No18911.7
1Yes16410.1
Missing1,26978.2%
CARBPROC - Carotid artery disease based on vasc/surg proc.
Col 21

Carotid artery disease based on: Vascular or surgical procedure to improve flow to the ipsilateral brain.

Usage Notes:

Collected on all versions of form 121, only collected on form 132 after WHI closeout.

ValueDescriptionN%
0No462.8
1Yes30718.9
Missing1,26978.2%