This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Cardiovascular Outcome Details (Form 121), CaD ppts

File NameData as ofPopulationData collectedOne row perRows
outc_cardio_cad_inv.dat2/17/2024CaDMain, Ext1Outcome Form4,516

This file contains outcomes collected through the end of Ext1. This file has one row for every form 121 recording outcome(s). A participant may have more than one of these forms and one form may record several different types of outcomes. Only the first occurrence of each outcome is counted, e.g. Limiting the file to rows where MI=1 will find a single row for each participant with a MI outcome. Note: strokes and carotid artery disease are in a separate file.

ID - WHI Participant Common ID
Col 1
NMissing
4,5160
ASCSOURCE - Ascertainment Source
Col 2
ValueDescriptionN%
1Local Form 1212,86863.5
2Central Form 1211,64836.5
ANGINA - Angina
Col 3
Usage Notes:

Angina was adjudicated for CT and OS participants during the core WHI study. Angina occurring on or after a Clinical MI is not counted.

ValueDescriptionN%
0No00
1Yes1,11724.7
Missing3,39975.3%
CABG - CABG
Col 4

Coronary Artery Bypass Graft (CABG)

Usage Notes:

CABG was adjudicated for CT and OS participants through Ext1.

ValueDescriptionN%
0No00
1Yes69715.4
Missing3,81984.6%
CHF - CHF
Col 5

Congestive Heart Failure (CHF)

Usage Notes:

CHF was adjudicated for CT and OS participants during the core WHI study.

ValueDescriptionN%
0No00
1Yes80617.8
Missing3,71082.2%
MI - Clinical MI
Col 6
Usage Notes:

Clinical MI was adjudicated for CT and OS participants through Ext1.

ValueDescriptionN%
0No00
1Yes1,32529.3
Missing3,19170.7%
CREVASC - Coronary Revascularization
Col 7

Coronary revascularization procedure (CABG or PTCA)

Usage Notes:

Defined as the first occurrence of CABG or PTCA. Coronary Revascularization was adjudicated for CT and OS participants through Ext1.

ValueDescriptionN%
0No00
1Yes2,03445
Missing2,48255%
PERIPH - PAD
Col 8

Peripheral Arterial Disease (PAD)

Usage Notes:

PAD was adjudicated for CT and OS participants through Ext1.

ValueDescriptionN%
0No00
1Yes3307.3
Missing4,18692.7%
PTCA - PTCA
Col 9

Percutaneous Transluminal Coronary Angioplasty (PTCA)

Usage Notes:

PTCA was adjudicated for CT and OS participants through Ext1.

ValueDescriptionN%
0No00
1Yes1,48933
Missing3,02767%
ECGPATTR - ECG pattern
Col 10
Usage Notes:

Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
1Evolving Q-wave AND evolv ST-T abnormalities2034.5
2Equiv Q-wave,evolv ST-T,new left BBB3738.3
3Q-waves or ST-T abnormalities suggestive of MI62913.9
8Other ECG pattern,ECG uncodable or normal ECG2,13147.2
9ECG not available60013.3
Missing58012.8%
CARDENZY - Cardiac enzyme info available
Col 11

Cardiac enzyme information available?

Usage Notes:

Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No1,15925.7
1Yes2,79261.8
Missing56512.5%
CKMGE2XP - CK-MB >= 2x uln for % or index
Col 12

CK-MB at least 2x upper limit of normal for % or index

Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,38652.8
1Yes3918.7
Missing1,73938.5%
CKMLT2XP - CK-MB > uln & < 2x uln
Col 13

CK-MB greater than upper limit of normal but less than 2x upper limit of normal for % or index

Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,58657.3
1Yes1914.2
Missing1,73938.5%
CKMNORMP - CK-MB within norm % or index
Col 14

CK-MB within normal limits for % or index

Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,42253.6
1Yes3557.9
Missing1,73938.5%
CKMGE2XU - CK-MB >= 2x uln for units
Col 15

CK-MB at least 2x upper limit of normal for units

Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,08946.3
1Yes68815.2
Missing1,73938.5%
CKMLT2XU - CK-MB > uln & < 2x uln units
Col 16

CK-MB greater than upper limit of normal but less than 2x upper limit of normal for units

Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,54356.3
1Yes2345.2
Missing1,73938.5%
CKMNORMU - CK-MB within normal for units
Col 17

CK-MB within normal limits for units

Usage Notes:

Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No1,74938.7
1Yes69815.5
Missing2,06945.8%
CKMBPRES - CK-MB `present` w/o quantification
Col 18

CK-MB reported as "present” without quantification

Usage Notes:

Not collected after the WHI study closeout. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No1,97743.8
1Yes40.1
Missing2,53556.1%
CKMBWEAK - CK-MB `weakly present` w/o quantification
Col 19

CK-MB reported as “weakly present” without quantification

Usage Notes:

Not collected after the WHI study closeout. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No1,97743.8
1Yes40.1
Missing2,53556.1%
TCKGE2X - Total CK >=2x upper limit of normal
Col 20

Total CK at least 2x upper limit of normal

Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,64458.5
1Yes1332.9
Missing1,73938.5%
TCKLT2X - Total CK> uln & <2x uln
Col 21

Total CK greater than upper limit of normal but less than 2x upper limit of normal

Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,66859.1
1Yes1092.4
Missing1,73938.5%
TCKNORM - Total CK within normal limits
Col 22
Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,17348.1
1Yes60413.4
Missing1,73938.5%
CKRESNA - CK result not available
Col 23
Usage Notes:

Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
0No2,48455
1Yes2936.5
Missing1,73938.5%
SERUMLDH - Serum lactate dehydrogenase
Col 24

Serum lactate dehydrogenase (LDH): (Complete only if no other cardiac enzymes are available.)

Usage Notes:

Not collected after the WHI study closeout. Coded for MI, Coronary Death (hosp), Coronary Revascularization, Angina and CHF.

ValueDescriptionN%
1LDH1 >= LDH220
2LDH1 < LDH2100.2
3LDH1 >= 2x ULN10
4LDH1 > ULN AND < 2x ULN40.1
5LDH1 within normal limits60.1
6Total LDH >= 2x ULN240.5
7Total LDH > ULN and < 2x ULN501.1
8Total LDH within normal limits1002.2
9LDH results not available1,46032.3
Missing2,85963.3%
TROPLTES - Troponin Lab Test
Col 25
Usage Notes:

Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
1Troponin C50.1
2Troponin I1,89842
3Troponin T1984.4
4Troponin, not specified1964.3
9Troponin not available4459.9
Missing1,77439.3%
TROPLRES - Troponin Lab Results
Col 26

Results (Mark the one category that applies best.) Troponin values should be coded using the upper limit of normal (ULN) and not upper limit of indeterminate/indecisive as the reference value. Thus, if 2 cutpoints are given, choose the lower cutpoint for the upper limit of normal.

Usage Notes:

Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.

ValueDescriptionN%
1Troponin >= 2x ULN1,23827.4
2Troponin > ULN & < 2x ULN1713.8
3Troponin within normal limits87919.5
9Other120.3
Missing2,21649.1%
CARDPAIN - Cardiac pain
Col 27

Cardiac pain defined as: an acute episode of pain, discomfort or tightness in the chest, arm, throat or jaw

Usage Notes:

Only coded for MIs through the core WHI study. In Ext1 it was coded for MI, coronary death (hosp) and coronary revascularization.

ValueDescriptionN%
1Present1,45132.1
2Absent3648.1
9Unknown/Not recorded2465.4
Missing2,45554.4%
MIDX - Clinical MI Diagnosis
Col 28
Usage Notes:

Not collected on early versions of Form 121. An MI is defined as procedure-related if it occurs within 30 days after any procedure.

ValueDescriptionN%
1MI not result of or during procedure1,12725
2MI during or resulting from procedure1844.1
Missing3,20571%
MIPROCTYP - MI Procedure Type
Col 29
Usage Notes:

Only coded for MIs. Only collected during Ext1.

ValueDescriptionN%
1MI within 24 hrs after cardiac procedure220.5
2MI 2-30 days after cardiac procedure130.3
3MI 30 days after non-cardiac procedure380.8
Missing4,44398.4%
THRMAGNT - Thrombolytic agent or revasc procedure
Col 30

Was a thrombolytic agent administered or emergent revascularization procedure (e.g., angioplasty or stent) performed?

Usage Notes:

Not collected on early versions of Form 121. Only coded for MI.

ValueDescriptionN%
0No98221.7
1Yes2806.2
9Unknown511.1
Missing3,20370.9%
MIABORT - Was MI aborted
Col 31

Was the myocardial infarction aborted? (Diagnosis of an aborted MI requires: symptoms and ECG evidence for acute MI at presentation; intervention [thrombolytic therapy or a procedure] followed by resolution of ECG changes; and all cardiac enzymes within normal limits.)

Usage Notes:

Not collected on early versions of Form 121. Not collected after the WHI closeout. Only has values if THRMAGNT is equal to 1 or 9.

ValueDescriptionN%
0No2024.5
1Yes80.2
9Unknown180.4
Missing4,28895%
MIFATAL - Was the MI fatal
Col 32

Was the myocardial infarction fatal?

Usage Notes:

Not collected on early versions of Form 121.

ValueDescriptionN%
0No1,20026.6
1Yes801.8
Missing3,23671.7%
ANGADMT - Angina MD diagnosis & treatment this admit
Col 33

Angina based on: Physician diagnosis of angina and receiving medical treatment at discharge, for angina on this admission (e.g., nitrate, beta-blocker, or calcium-channel blocker)

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No1443.2
1Yes96921.5
Missing3,40375.4%
ANGADMTP - Angina MD diagnosis & treament & cath hist.
Col 34

Angina based on: Physician diagnosis of angina and receiving medical treatment for angina on this admission plus current medical record documenting a history of coronary heart disease by previous catheterization or revascularization procedure

Usage Notes:

Not collected on early versions of F121. Not collected after the WHI study closeout.

ValueDescriptionN%
0No86219.1
1Yes2265
Missing3,42875.9%
CABGOTHR - Angina CABG or other revasc this admit
Col 35

Angina based on: CABG surgery or other revascularization procedure on this admission.

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No55312.2
1Yes56012.4
Missing3,40375.4%
ANG70GT - Angina based on >= 70% obstruc
Col 36

Angina based on: 70% or greater obstruction of any coronary artery on angiography on this admission

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No48410.7
1Yes62913.9
Missing3,40375.4%
STSEGMNT - Angina based on ST-segment dep
Col 37

Angina based on: Horizontal or down-sloping ST-segment depression or abnormal ST elevation >= 1 mm on exercise or pharmacological stress testing with pain on this admission

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No1,06523.6
1Yes481.1
Missing3,40375.4%
STRETEST - Angina Stress test positive for ischemia
Col 38

Angina based on: Scintigraphic or echocardiographic stress test positive for ischemia on this admission

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No96821.4
1Yes1453.2
Missing3,40375.4%
ANGECGST - Angina based on ECG STs
Col 39

Angina based on: Resting ECG shows horizontal or down-sloping ST depression or abnormal ST elevation >= 1 mm with pain that is not present on ECG without pain on this admission

Usage Notes:

Not collected on early versions of F121. Not collected after the WHI study closeout.

ValueDescriptionN%
0No1,06523.6
1Yes230.5
Missing3,42875.9%
CHFDXTX - CHF MD diagnosis & treatment this admit
Col 40

CHF based on: Congestive failure diagnosed by physician and receiving medical treatment for CHF on this admission (e.g., diuretic, digitalis, vasodilator and/or angiotensin-converting enzyme inhibitor)

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No942.1
1Yes71015.7
Missing3,71282.2%
CHFDXTXI - CHF MD Diagnosis, treatment + imaging
Col 41

CHF based on: Congestive failure diagnosed by physician and receiving medical treatment on this admission plus current medical record documents a history of an imaging procedure showing impaired systolic or diastolic LV function

Usage Notes:

Not collected on early versions of Form 121. Not collected after the WHI study closeout.

ValueDescriptionN%
0No63114
1Yes1643.6
Missing3,72182.4%
CHFPULM - CHF Pulmonary edema chest X-ray this admit
Col 42

CHF based on: Pulmonary edema\congestion by chest X-ray on this admission

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No2585.7
1Yes54612.1
Missing3,71282.2%
CHFDIVNT - CHF Dilated ventricle or poor left function
Col 43

CHF based on: On this admission, dilated ventricle or poor left (or right-side) ventricular function (e.g., wall motion abnormalities) by echocardiography; radionuclide ventriculogram (RVG)/multigated acquisition (MUGA), or other contrast ventriculography, or evidence of left ventricular diastolic dysfunction

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No52911.7
1Yes2756.1
Missing3,71282.2%
CHFFATAL - CHF fatal
Col 44

Was the congestive heart failure fatal?

Usage Notes:

Not collected after the WHI study closeout.

ValueDescriptionN%
0No71615.9
1Yes210.5
Missing3,77983.7%
CORR2MI - Coronary revasc: Second MI
Col 45

Second myocardial infarction (MI) (i.e., second MI not already reported in Question 4) occurring as a result of or during the revascularization procedure.

Usage Notes:

Not collected on early versions of Form 121. Only coded for coronary revascularizations (CABG/PTCA).

ValueDescriptionN%
0No1,57034.8
1Yes380.8
9Unknown3357.4
Missing2,57357%
PADDX - PAD diagnosis
Col 46

Diagnosis: (Mark the one category that applies best.)

Usage Notes:

Value 4 was not available on early versions of form 121.

ValueDescriptionN%
1Lower extremity claudication932.1
2Atherosclerosis of arteries of the lower extremities1513.3
3Arterial embolism and/or thrombosis of the lower extremities350.8
4Abdominal aortic anuerysm (AAA)481.1
Missing4,18992.8%
PADPLAQ - Ultrasonography or angiography
Col 47

PAD based on: Ultrasonographically- or angiographically-demonstrated obstruction, or ulcerated plaque (>= 50% of the diameter or >= 75% of the cross-sectional area) demonstrated on ultrasound or angiogram of the iliac arteries or below

ValueDescriptionN%
0No1633.6
1Yes1653.7
Missing4,18892.7%
PADABDOP - No Doppler pulse in vessels
Col 48

PAD based on: Absence of pulse by doppler in any major vessel of lower extremities

ValueDescriptionN%
0No3026.7
1Yes260.6
Missing4,18892.7%
PADEXER - Positive exercise test
Col 49

PAD based on: Exercise test that is positive for lower extremity claudication

ValueDescriptionN%
0No3247.2
1Yes40.1
Missing4,18892.7%
PADSURG - Surgery, angioplasty or thromb
Col 50

PAD based on: Surgery, angioplasty, or thrombolysis for peripheral arterial disease

ValueDescriptionN%
0No972.1
1Yes2315.1
Missing4,18892.7%
PADAMP - PAD Amputation of one or more toes
Col 51

PAD based on: Amputation of one or more toes or part of the lower extremity because of ischemia or gangrene

ValueDescriptionN%
0No3147
1Yes140.3
Missing4,18892.7%
PADLEG - Exertional leg pain
Col 52

PAD based on: Exertional leg pain relieved by rest and at least one of the following: (1) claudication diagnosed by physician, or (2) ankle-arm systolic blood pressure ratio <= 0.8

ValueDescriptionN%
0No2565.7
1Yes721.6
Missing4,18892.7%
PADULANR - Abdominal aortic aneurysm
Col 53

PAD based on: Ultrasonographically- or angiographically-demonstrated abdominal aortic aneurysm

Usage Notes:

Not collected on early versions of Form 121.

ValueDescriptionN%
0No2846.3
1Yes330.7
Missing4,19993%
PADSRANR - Surgical/Vascular proc for AAA
Col 54

PAD based on: Surgical or vascular procedure for abdominal aortic aneurysm

Usage Notes:

Not collected on early versions of Form 121.

ValueDescriptionN%
0No2736
1Yes441
Missing4,19993%