This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Self-Reported Outcomes, Main through Extension Study 1

File Name	Data as of	Population	Data collected	One row per	Rows
outc_self_ctos_inv.dat	2/17/2024	CT+OS	Main, Ext1	Participant	161,808

ID - WHI Participant Common ID

Col 1

N	Missing	Min	Max	Mean	StdDev
161,808	0	100,001	299,999	199,984.746	57,687.336

F33ANGHOSP - F33 Angina

Col 2

Usage Notes:

During the WHI Extension Study 1 this variable indicates self reported angina with hospitalization for a heart condition that may or may not be related to the angina. This variable differs from the WHI Extension Study 2 definition of self reported angina.

Value	Description	N	%
0	No	152,324	94.1
1	Yes	8,607	5.3
	Missing	877	0.5%

F33ANGHOSPDY - Days enrollment to F33 Angina

Col 3

N	Missing	Min	Max	Mean	StdDev
8,607	153,201	18	5,957	2,202.43	1,354.538

F33CHF - F33 Congestive Heart Failure

Col 4

Usage Notes:

Only hospitalized CHF was collected through the WHI Extension Study 1.

Value	Description	N	%
0	No	157,980	97.6
1	Yes	2,951	1.8
	Missing	877	0.5%

F33CHFDY - Days enrollment to F33 Congestive Heart Failure

Col 5

N	Missing	Min	Max	Mean	StdDev
2,951	158,857	48	5,973	2,415.428	1,453.356

F33DVT - F33 Deep Vein Thrombosis

Col 6

Value	Description	N	%
0	No	157,572	97.4
1	Yes	3,359	2.1
	Missing	877	0.5%

F33DVTDY - Days enrollment to F33 Deep Vein Thrombosis

Col 7

N	Missing	Min	Max	Mean	StdDev
3,359	158,449	42	5,922	2,586.481	1,396.657

F33PE - F33 Pulmonary Embolism

Col 8

Usage Notes:

Only hospitalized PE events were collected through the WHI Extension Study 1.

Value	Description	N	%
0	No	159,019	98.3
1	Yes	1,912	1.2
	Missing	877	0.5%

F33PEDY - Days enrollment to F33 Pulmonary Embolism

Col 9

N	Missing	Min	Max	Mean	StdDev
1,912	159,896	10	5,812	2,874.839	1,446.098

F33NMSC - F33 Non-Melanoma Skin Cancer

Col 10

Value	Description	N	%
0	No	136,756	84.5
1	Yes	24,175	14.9
	Missing	877	0.5%

F33NMSCDY - Days enrollment to F33 Non-Melanoma Skin Cancer

Col 11

N	Missing	Min	Max	Mean	StdDev
24,175	137,633	71	5,926	2,422.385	1,406.862

F33BKULEG - F33 Broken Upper Leg

Col 12

Value	Description	N	%
0	No	159,381	98.5
1	Yes	1,550	1
	Missing	877	0.5%

F33BKULEGDY - Days enrollment to F33 Broken Upper Leg

Col 13

N	Missing	Min	Max	Mean	StdDev
1,550	160,258	170	5,945	3,192.106	1,387.768

F33BKPELV - F33 Broken Pelvis

Col 14

Value	Description	N	%
0	No	158,713	98.1
1	Yes	2,218	1.4
	Missing	877	0.5%

F33BKPELVDY - Days enrollment to F33 Broken Pelvis

Col 15

N	Missing	Min	Max	Mean	StdDev
2,218	159,590	30	5,865	3,041.18	1,383.013

F33BKKNEE - F33 Broken Knee

Col 16

Value	Description	N	%
0	No	158,342	97.9
1	Yes	2,589	1.6
	Missing	877	0.5%

F33BKKNEEDY - Days enrollment to F33 Broken Knee

Col 17

N	Missing	Min	Max	Mean	StdDev
2,589	159,219	167	5,810	2,788.441	1,456.127

F33BKSPINE - F33 Broken Spine

Col 18

Value	Description	N	%
0	No	155,087	95.8
1	Yes	5,844	3.6
	Missing	877	0.5%

F33BKSPINEDY - Days enrollment to F33 Broken Spine

Col 19

N	Missing	Min	Max	Mean	StdDev
5,844	155,964	155	5,846	2,985.949	1,389.395

F33BKUARM - F33 Broken Upper Arm

Col 20

Value	Description	N	%
0	No	156,256	96.6
1	Yes	4,675	2.9
	Missing	877	0.5%

F33BKUARMDY - Days enrollment to F33 Broken Upper Arm

Col 21

N	Missing	Min	Max	Mean	StdDev
4,675	157,133	30	5,790	2,814.857	1,440.04

F33BKLARM - F33 Broken Lower Arm

Col 22

Value	Description	N	%
0	No	151,700	93.8
1	Yes	9,231	5.7
	Missing	877	0.5%

F33BKLARMDY - Days enrollment to F33 Broken Lower Arm

Col 23

N	Missing	Min	Max	Mean	StdDev
9,231	152,577	56	5,913	2,484.305	1,436.175

F33BKHAND - F33 Broken Hand

Col 24

Value	Description	N	%
0	No	159,344	98.5
1	Yes	1,587	1
	Missing	877	0.5%

F33BKHANDDY - Days enrollment to F33 Broken Hand

Col 25

N	Missing	Min	Max	Mean	StdDev
1,587	160,221	166	5,846	2,734.948	1,499.103

F33BKLLEG - F33 Broken Lower Leg

Col 26

Value	Description	N	%
0	No	153,768	95
1	Yes	7,163	4.4
	Missing	877	0.5%

F33BKLLEGDY - Days enrollment to F33 Broken Lower Leg

Col 27

N	Missing	Min	Max	Mean	StdDev
7,163	154,645	43	5,898	2,435.969	1,449.106

F33BKFOOT - F33 Broken Foot

Col 28

Value	Description	N	%
0	No	154,373	95.4
1	Yes	6,558	4.1
	Missing	877	0.5%

F33BKFOOTDY - Days enrollment to F33 Broken Foot

Col 29

N	Missing	Min	Max	Mean	StdDev
6,558	155,250	72	5,904	2,510.983	1,452.189

F33BKTAILBN - F33 Broken Tailbone

Col 30

Value	Description	N	%
0	No	160,220	99
1	Yes	711	0.4
	Missing	877	0.5%

F33BKTAILBNDY - Days enrollment to F33 Broken Tailbone

Col 31

N	Missing	Min	Max	Mean	StdDev
711	161,097	168	5,799	3,029.94	1,410.118

F33BKELBOW - F33 Broken Elbow

Col 32

Value	Description	N	%
0	No	158,980	98.3
1	Yes	1,951	1.2
	Missing	877	0.5%

F33BKELBOWDY - Days enrollment to F33 Broken Elbow

Col 33

N	Missing	Min	Max	Mean	StdDev
1,951	159,857	121	5,788	2,596.969	1,450.42

F33BKOTHBN - F33 Broken Other Bone

Col 34

Usage Notes:

Any bone other than hip, upper leg, lower leg, upper arm, lower arm, hand, foot, elbow, knee, tailbone, or pelvis. Exceptions: for F33V1 and F33V2, tailbone and pelvis are included. During WHI Extension Study 1, cervical spine/neck is included.

Value	Description	N	%
0	No	138,570	85.6
1	Yes	22,361	13.8
	Missing	877	0.5%

F33BKOTHBNDY - Days enrollment to F33 Broken Other Bone

Col 35

N	Missing	Min	Max	Mean	StdDev
22,361	139,447	21	5,978	2,316.353	1,381.042

F33ANYFXNONHIP - F33 Any Non-Hip Fracture

Col 36

Usage Notes:

Any F33 fracture except hip (includes other bone).

Value	Description	N	%
0	No	113,265	70
1	Yes	47,666	29.5
	Missing	877	0.5%

F33ANYFXNONHIPDY - Days enrollment to F33 Any Non-Hip Fracture

Col 37

Usage Notes:

Earliest F33 non-hip fracture.

N	Missing	Min	Max	Mean	StdDev
47,666	114,142	21	5,978	2,316.109	1,409.859

F33HYST - F33 Hysterectomy Ever

Col 38

Value	Description	N	%
0	No	152,883	94.5
1	Yes	8,048	5
	Missing	877	0.5%

F33HYSTDY - Days enrollment to F33 Hysterectomy Ever

Col 39

N	Missing	Min	Max	Mean	StdDev
8,048	153,760	49	5,821	2,247.051	1,372.343

F33GALL - F33 Gallbladder Disease

Col 40

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	148,227	91.6
1	Yes	12,659	7.8
	Missing	922	0.6%

F33GALLDY - Days enrollment to F33 Gallbladder Disease

Col 41

N	Missing	Min	Max	Mean	StdDev
12,659	149,149	61	4,094	1,567.044	885.473

F33GLAUCOMA - F33 Glaucoma

Col 42

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	142,692	88.2
1	Yes	18,194	11.2
	Missing	922	0.6%

F33GLAUCOMADY - Days enrollment to F33 Glaucoma

Col 43

N	Missing	Min	Max	Mean	StdDev
18,194	143,614	129	4,009	1,667.44	905.233

F33OSTEOP - F33 Osteoporosis

Col 44

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	120,614	74.5
1	Yes	40,272	24.9
	Missing	922	0.6%

F33OSTEOPDY - Days enrollment to F33 Osteoporosis

Col 45

N	Missing	Min	Max	Mean	StdDev
40,272	121,536	91	4,017	1,534.727	863.002

F33OSTEOAR - F33 Osteoarthritis

Col 46

Usage Notes:

Not collected on all versions of F33.

Value	Description	N	%
0	No	89,153	55.1
1	Yes	71,620	44.3
	Missing	1,035	0.6%

F33OSTEOARDY - Days enrollment to F33 Osteoarthritis

Col 47

N	Missing	Min	Max	Mean	StdDev
71,620	90,188	33	5,873	2,037.784	1,341.752

F33RHEUM - F33 Rheumatoid Arthritis

Col 48

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	150,459	93
1	Yes	10,427	6.4
	Missing	922	0.6%

F33RHEUMDY - Days enrollment to F33 Rheumatoid Arthritis

Col 49

N	Missing	Min	Max	Mean	StdDev
10,427	151,381	152	3,994	1,527.039	896.908

F33INTPOLYP - F33 Intestinal Polyps

Col 50

Value	Description	N	%
0	No	122,981	76
1	Yes	37,905	23.4
	Missing	922	0.6%

F33INTPOLYPDY - Days enrollment to F33 Intestinal Polyps

Col 51

N	Missing	Min	Max	Mean	StdDev
37,905	123,903	75	5,999	2,314.556	1,332.575

F33KIDNEYST - F33 Kidney Stones

Col 52

Usage Notes:

Not collected after WHI study closeout. Not collected on all versions of F33.

Value	Description	N	%
0	No	155,017	95.8
1	Yes	4,928	3
	Missing	1,863	1.2%

F33KIDNEYSTDY - Days enrollment to F33 Kidney Stones

Col 53

N	Missing	Min	Max	Mean	StdDev
4,928	156,880	152	3,970	1,797.405	852.124

F33LUPUS - F33 Lupus

Col 54

Value	Description	N	%
0	No	158,438	97.9
1	Yes	2,448	1.5
	Missing	922	0.6%

F33LUPUSDY - Days enrollment to F33 Lupus

Col 55

N	Missing	Min	Max	Mean	StdDev
2,448	159,360	151	5,754	2,229.156	1,378.934

F33CATARACT - F33 Cataracts

Col 56

Usage Notes:

Not collected after WHI study closeout. Not collected on all versions of F33.

Value	Description	N	%
0	No	100,020	61.8
1	Yes	59,925	37
	Missing	1,863	1.2%

F33CATARACTDY - Days enrollment to F33 Cataracts

Col 57

N	Missing	Min	Max	Mean	StdDev
59,925	101,883	119	4,056	1,614.787	843.02

F33PILLSHYP - F33 Pills For Hypertension

Col 58

Value	Description	N	%
0	No	67,947	42
1	Yes	92,939	57.4
	Missing	922	0.6%

F33PILLSHYPDY - Days enrollment to F33 Pills For Hypertension

Col 59

N	Missing	Min	Max	Mean	StdDev
92,939	68,869	0	5,916	1,583.979	1,318.14

F33DIABTX - F33 Diabetes Treated

Col 60

Pills or insulin shots

Usage Notes:

Pills or insulin shots.

Value	Description	N	%
0	No	138,788	85.8
1	Yes	22,098	13.7
	Missing	922	0.6%

F33DIABTXDY - Days enrollment to F33 Diabetes Treated

Col 61

N	Missing	Min	Max	Mean	StdDev
22,098	139,710	1	5,951	2,056.877	1,502.375

F33DIABINSULIN - F33 Diabetes Insulin

Col 62

Value	Description	N	%
0	No	154,281	95.3
1	Yes	6,605	4.1
	Missing	922	0.6%

F33DIABINSULINDY - Days enrollment to F33 Diabetes Insulin

Col 63

N	Missing	Min	Max	Mean	StdDev
6,605	155,203	1	5,961	2,367.742	1,582.521

F33DIABPILLS - F33 Diabetes Pills

Col 64

Value	Description	N	%
0	No	140,066	86.6
1	Yes	20,820	12.9
	Missing	922	0.6%

F33DIABPILLSDY - Days enrollment to F33 Diabetes Pills

Col 65

N	Missing	Min	Max	Mean	StdDev
20,820	140,988	33	5,951	2,107.348	1,492.303

F33OSTEOPILLS - F33 Osteoporosis Pills

Col 66

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	94,071	58.1
1	Yes	20,662	12.8
	Missing	47,075	29.1%

F33OSTEOPILLSDY - Days enrollment to F33 Osteoporosis Pills

Col 67

N	Missing	Min	Max	Mean	StdDev
20,662	141,146	2,498	5,962	3,919.101	660.841

F33OSTEOPCALC - F33 Osteoporosis Calcium

Col 68

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	94,390	58.3
1	Yes	20,343	12.6
	Missing	47,075	29.1%

F33OSTEOPCALCDY - Days enrollment to F33 Osteoporosis Calcium

Col 69

N	Missing	Min	Max	Mean	StdDev
20,343	141,465	2,500	5,962	3,998.047	671.092

F33PARKINSONS - F33 Parkinsons

Col 70

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	114,084	70.5
1	Yes	1,323	0.8
	Missing	46,401	28.7%

F33PARKINSONSDY - Days enrollment to F33 Parkinsons

Col 71

N	Missing	Min	Max	Mean	StdDev
1,323	160,485	2,505	5,902	4,146.733	659.948

F33ALZHEIMERS - F33 Alzheimers

Col 72

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	109,673	67.8
1	Yes	5,734	3.5
	Missing	46,401	28.7%

F33ALZHEIMERSDY - Days enrollment to F33 Alzheimers

Col 73

N	Missing	Min	Max	Mean	StdDev
5,734	156,074	2,505	5,973	4,230.207	681.423

F33CHOLESPILLS - F33 Cholesterol Pills

Col 74

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	85,051	52.6
1	Yes	30,356	18.8
	Missing	46,401	28.7%

F33CHOLESPILLSDY - Days enrollment to F33 Cholesterol Pills

Col 75

N	Missing	Min	Max	Mean	StdDev
30,356	131,452	2,498	5,957	3,898.75	662.452

F33ESTROGEN - F33 Estrogen or Estrogen Combination Pills

Col 76

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	111,300	68.8
1	Yes	4,107	2.5
	Missing	46,401	28.7%

F33ESTROGENDY - Days Enrollment to F33 Estrogen or Estrogen Combo

Col 77

N	Missing	Min	Max	Mean	StdDev
4,107	157,701	2,501	5,990	3,981.911	671.114

F33DEPRESSION - F33 Treatment for Depression

Col 78

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	102,609	63.4
1	Yes	12,798	7.9
	Missing	46,401	28.7%

F33DEPRESSIONDY - Days Enrollment to F33 Treatment for Depression

Col 79

N	Missing	Min	Max	Mean	StdDev
12,798	149,010	2,455	5,989	4,023.262	672.802

F33ANXIETY - F33 Treatment for Anxiety

Col 80

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	107,254	66.3
1	Yes	8,153	5
	Missing	46,401	28.7%

F33ANXIETYDY - Days enrollment to F33 Treatment for Anxiety

Col 81

N	Missing	Min	Max	Mean	StdDev
8,153	153,655	2,505	5,973	4,090.097	679.457

F33DIABDIETEX - F33 Diet and/or Exercise for Diabetes

Col 82

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	108,345	67
1	Yes	7,062	4.4
	Missing	46,401	28.7%

F33DIABDIETEXDY - Days enrollment to F33 Diet/Exercise for Diabetes

Col 83

N	Missing	Min	Max	Mean	StdDev
7,062	154,746	2,500	5,961	3,988.818	673.48

F33MACDEGEN - F33 Macular Degeneration

Col 84

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	107,012	66.1
1	Yes	8,395	5.2
	Missing	46,401	28.7%

F33MACDEGENDY - Days enrollment to F33 Macular Degeneration

Col 85

N	Missing	Min	Max	Mean	StdDev
8,395	153,413	2,499	5,983	4,031.98	683.415

LAST33WHIDY - Days enrollment to last WHI form 33/33D

Col 86

Usage Notes:

LAST33WHIDY is calculated as the days from enrollment to the latest Form 33 in the WHI study. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33WHIDY.

N	Missing	Min	Max	Mean	StdDev
160,931	877	1	4,094	2,834.256	594.954

LAST33EXT1DY - Days enrollment to last Ext1 form 33/33D

Col 87

Usage Notes:

LAST33EXT1DY is calculated as the days from enrollment to the latest Form 33 in Extension Study 1. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33EXT1DY.

N	Missing	Min	Max	Mean	StdDev
114,837	46,971	2,455	6,047	4,813.252	474.872

F33HOSPWHI - F33 Hospitalized Ever in WHI

Col 88

Value	Description	N	%
0	No	82,877	51.2
1	Yes	78,931	48.8

F33HOSPX1 - F33 Hospitalized Ever in Ext1

Col 89

Value	Description	N	%
0	No	68,734	42.5
1	Yes	46,103	28.5
	Missing	46,971	29%

F33HOSPTIMESWHI - F33 Number of WHI Hospitalizations Categorized

Col 90

Value	Description	N	%
0	0	82,000	50.7
1	1	37,047	22.9
2	2	18,678	11.5
3	3 or more	23,206	14.3
	Missing	877	0.5%

F33HOSPTIMESX1 - F33 Number of Ext1 Hospitalizations Categorized

Col 91

Value	Description	N	%
0	0	68,734	42.5
1	1	24,595	15.2
2	2	11,254	7
3	3 or more	10,254	6.3
	Missing	46,971	29%