This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Self-Reported Outcomes, Main through Extension Study 1, CaD ppts

File Name	Data as of	Population	Data collected	One row per	Rows
outc_self_cad_inv.dat	2/17/2024	CaD	Main, Ext1	Participant	36,282

ID - WHI Participant Common ID

Col 1

N	Missing	Min	Max	Mean	StdDev
36,282	0	100,005	299,988	199,993.399	57,765.26

F33ANGHOSP - F33 Angina

Col 2

Usage Notes:

During the WHI Extension Study 1 this variable indicates self reported angina with hospitalization for a heart condition that may or may not be related to the angina. This variable differs from the WHI Extension Study 2 definition of self reported angina.

Value	Description	N	%
0	No	34,392	94.8
1	Yes	1,829	5
	Missing	61	0.2%

F33ANGHOSPDY - Days enrollment to F33 Angina

Col 3

N	Missing	Min	Max	Mean	StdDev
1,829	34,453	62	5,363	2,075.381	1,302.254

F33CHF - F33 Congestive Heart Failure

Col 4

Usage Notes:

Only hospitalized CHF was collected through the WHI Extension Study 1.

Value	Description	N	%
0	No	35,577	98.1
1	Yes	644	1.8
	Missing	61	0.2%

F33CHFDY - Days enrollment to F33 Congestive Heart Failure

Col 5

N	Missing	Min	Max	Mean	StdDev
644	35,638	99	5,497	2,277.689	1,452.981

F33DVT - F33 Deep Vein Thrombosis

Col 6

Value	Description	N	%
0	No	35,373	97.5
1	Yes	848	2.3
	Missing	61	0.2%

F33DVTDY - Days enrollment to F33 Deep Vein Thrombosis

Col 7

N	Missing	Min	Max	Mean	StdDev
848	35,434	72	5,460	2,432.032	1,379.198

F33PE - F33 Pulmonary Embolism

Col 8

Usage Notes:

Only hospitalized PE events were collected through the WHI Extension Study 1.

Value	Description	N	%
0	No	35,748	98.5
1	Yes	473	1.3
	Missing	61	0.2%

F33PEDY - Days enrollment to F33 Pulmonary Embolism

Col 9

N	Missing	Min	Max	Mean	StdDev
473	35,809	72	5,383	2,630.55	1,361.432

F33NMSC - F33 Non-Melanoma Skin cancer

Col 10

Value	Description	N	%
0	No	31,079	85.7
1	Yes	5,142	14.2
	Missing	61	0.2%

F33NMSCDY - Days enrollment to F33 Non-Melanoma Skin Cancer

Col 11

N	Missing	Min	Max	Mean	StdDev
5,142	31,140	62	5,374	2,211.891	1,357.545

F33BKULEG - F33 Broken Upper Leg

Col 12

Value	Description	N	%
0	No	35,895	98.9
1	Yes	326	0.9
	Missing	61	0.2%

F33BKULEGDY - Days enrollment to F33 Broken Upper Leg

Col 13

N	Missing	Min	Max	Mean	StdDev
326	35,956	167	5,406	2,999.402	1,309.445

F33BKPELV - F33 Broken Pelvis

Col 14

Value	Description	N	%
0	No	35,812	98.7
1	Yes	409	1.1
	Missing	61	0.2%

F33BKPELVDY - Days enrollment to F33 Broken Pelvis

Col 15

N	Missing	Min	Max	Mean	StdDev
409	35,873	161	5,497	2,918.768	1,290.302

F33BKKNEE - F33 Broken Knee

Col 16

Value	Description	N	%
0	No	35,642	98.2
1	Yes	579	1.6
	Missing	61	0.2%

F33BKKNEEDY - Days enrollment to F33 Broken Knee

Col 17

N	Missing	Min	Max	Mean	StdDev
579	35,703	68	5,264	2,616.473	1,371.871

F33BKSPINE - F33 Broken Spine

Col 18

Value	Description	N	%
0	No	35,042	96.6
1	Yes	1,179	3.2
	Missing	61	0.2%

F33BKSPINEDY - Days enrollment to F33 Broken Spine

Col 19

N	Missing	Min	Max	Mean	StdDev
1,179	35,103	154	5,448	2,812.087	1,347.648

F33BKUARM - F33 Broken Upper Arm

Col 20

Value	Description	N	%
0	No	35,138	96.8
1	Yes	1,083	3
	Missing	61	0.2%

F33BKUARMDY - Days enrollment to F33 Broken Upper Arm

Col 21

N	Missing	Min	Max	Mean	StdDev
1,083	35,199	122	5,373	2,573.811	1,362.222

F33BKLARM - F33 Broken Lower Arm

Col 22

Value	Description	N	%
0	No	34,143	94.1
1	Yes	2,078	5.7
	Missing	61	0.2%

F33BKLARMDY - Days enrollment to F33 Broken Lower Arm

Col 23

N	Missing	Min	Max	Mean	StdDev
2,078	34,204	89	5,468	2,351.781	1,373.482

F33BKHAND - F33 Broken Hand

Col 24

Value	Description	N	%
0	No	35,861	98.8
1	Yes	360	1
	Missing	61	0.2%

F33BKHANDDY - Days enrollment to F33 Broken Hand

Col 25

N	Missing	Min	Max	Mean	StdDev
360	35,922	88	5,116	2,445.439	1,402.667

F33BKLLEG - F33 Broken Lower Leg

Col 26

Value	Description	N	%
0	No	34,568	95.3
1	Yes	1,653	4.6
	Missing	61	0.2%

F33BKLLEGDY - Days enrollment to F33 Broken Lower Leg

Col 27

N	Missing	Min	Max	Mean	StdDev
1,653	34,629	62	5,396	2,295.909	1,376.702

F33BKFOOT - F33 Broken Foot

Col 28

Value	Description	N	%
0	No	34,769	95.8
1	Yes	1,452	4
	Missing	61	0.2%

F33BKFOOTDY - Days enrollment to F33 Broken Foot

Col 29

N	Missing	Min	Max	Mean	StdDev
1,452	34,830	62	5,296	2,338.315	1,382.569

F33BKTAILBN - F33 Broken Tailbone

Col 30

Value	Description	N	%
0	No	36,067	99.4
1	Yes	154	0.4
	Missing	61	0.2%

F33BKTAILBNDY - Days enrollment to F33 Broken Tailbone

Col 31

N	Missing	Min	Max	Mean	StdDev
154	36,128	134	5,296	2,731.227	1,402.74

F33BKELBOW - F33 Broken Elbow

Col 32

Value	Description	N	%
0	No	35,806	98.7
1	Yes	415	1.1
	Missing	61	0.2%

F33BKELBOWDY - Days enrollment to F33 Broken Elbow

Col 33

N	Missing	Min	Max	Mean	StdDev
415	35,867	62	5,111	2,271.333	1,407.626

F33BKOTHBN - F33 Broken Other Bone

Col 34

Usage Notes:

Any bone other than hip, upper leg, lower leg, upper arm, lower arm, hand, foot, elbow, knee, tailbone, or pelvis. Exceptions: for F33V1 and F33V2, tailbone and pelvis are included. During WHI Extension Study 1, cervical spine/neck is included.

Value	Description	N	%
0	No	31,600	87.1
1	Yes	4,621	12.7
	Missing	61	0.2%

F33BKOTHBNDY - Days enrollment to F33 Broken Other Bone

Col 35

N	Missing	Min	Max	Mean	StdDev
4,621	31,661	62	5,485	2,152.11	1,331.146

F33ANYFXNONHIP - F33 Any Non-Hip Fracture

Col 36

Any fracture except hip (includes other bone).

Value	Description	N	%
0	No	25,872	71.3
1	Yes	10,410	28.7

F33ANYFXNONHIPDY - Days enrollment to F33 Any Non-Hip Fracture

Col 37

Usage Notes:

Earliest F33 non-hip fracture.

N	Missing	Min	Max	Mean	StdDev
10,410	25,872	62	5,485	2,184.301	1,357.366

F33HYST - F33 Hysterectomy Ever

Col 38

Value	Description	N	%
0	No	34,581	95.3
1	Yes	1,640	4.5
	Missing	61	0.2%

F33HYSTDY - Days enrollment to F33 Hysterectomy Ever

Col 39

N	Missing	Min	Max	Mean	StdDev
1,640	34,642	84	5,361	2,156.537	1,328.82

F33DIABPILLS - F33 Diabetes Pills

Col 40

Value	Description	N	%
0	No	30,894	85.1
1	Yes	5,325	14.7
	Missing	63	0.2%

F33DIABPILLSDY - Days enrollment to F33 Diabetes Pills

Col 41

N	Missing	Min	Max	Mean	StdDev
5,325	30,957	62	5,400	1,953.639	1,411.599

F33DIABINSULIN - F33 Diabetes Insulin

Col 42

Value	Description	N	%
0	No	34,654	95.5
1	Yes	1,565	4.3
	Missing	63	0.2%

F33DIABINSULINDY - Days enrollment to F33 Diabetes Insulin

Col 43

N	Missing	Min	Max	Mean	StdDev
1,565	34,717	84	5,400	2,281.384	1,485.656

F33DIABTX - F33 Diabetes Treated

Col 44

Usage Notes:

Pills or insulin shots.

Value	Description	N	%
0	No	30,592	84.3
1	Yes	5,627	15.5
	Missing	63	0.2%

F33DIABTXDY - Days enrollment to F33 Diabetes Treated

Col 45

N	Missing	Min	Max	Mean	StdDev
5,627	30,655	62	5,400	1,926.066	1,417.81

F33DIABDIETEX - F33 Diet and/or Exercise for Diabetes

Col 46

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	27,967	77.1
1	Yes	1,895	5.2
	Missing	6,420	17.7%

F33DIABDIETEXDY - Days enrollment to F33 Diabetes Exercise

Col 47

N	Missing	Min	Max	Mean	StdDev
1,895	34,387	2,122	5,410	3,688.844	655.435

F33PILLSHYP - F33 Pills For Hypertension

Col 48

Value	Description	N	%
0	No	15,059	41.5
1	Yes	21,160	58.3
	Missing	63	0.2%

F33PILLSHYPDY - Days enrollment to F33 Pills For Hypertension

Col 49

N	Missing	Min	Max	Mean	StdDev
21,160	15,122	61	5,492	1,483.512	1,253.838

F33DEPRESSION - F33 Depression Tx

Col 50

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	26,859	74
1	Yes	3,003	8.3
	Missing	6,420	17.7%

F33DEPRESSIONDY - Days Enrollment to F33 Depression Tx

Col 51

N	Missing	Min	Max	Mean	StdDev
3,003	33,279	2,094	5,517	3,718.783	657.552

F33ANXIETY - F33 Anxiety Tx

Col 52

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	28,089	77.4
1	Yes	1,773	4.9
	Missing	6,420	17.7%

F33ANXIETYDY - Days enrollment to F33 Anxiety Tx

Col 53

N	Missing	Min	Max	Mean	StdDev
1,773	34,509	2,158	5,493	3,823.395	658.363

F33OSTEOPILLS - F33 Osteoporosis Pills

Col 54

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	24,714	68.1
1	Yes	4,915	13.5
	Missing	6,653	18.3%

F33OSTEOPILLSDY - Days enrollment to F33 Osteoporosis Pills

Col 55

N	Missing	Min	Max	Mean	StdDev
4,915	31,367	2,125	5,384	3,612.766	644.112

F33OSTEOPCALC - F33 Osteoporosis Calcium

Col 56

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	24,914	68.7
1	Yes	4,715	13
	Missing	6,653	18.3%

F33OSTEOPCALCDY - Days enrollment to F33 Osteoporosis Calcium

Col 57

N	Missing	Min	Max	Mean	StdDev
4,715	31,567	2,098	5,531	3,702.482	658.887

F33CHOLESPILLS - F33 Cholesterol Pills

Col 58

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	21,955	60.5
1	Yes	7,907	21.8
	Missing	6,420	17.7%

F33CHOLESPILLSDY - Days enrollment to F33 Cholesterol Pills

Col 59

N	Missing	Min	Max	Mean	StdDev
7,907	28,375	2,093	5,492	3,598.147	647.491

F33ESTROGEN - F33 Estrogen or Estrogen Combination Pills

Col 60

Usage Notes:

Only collected during the WHI Extension Study 1.

Value	Description	N	%
0	No	28,983	79.9
1	Yes	879	2.4
	Missing	6,420	17.7%

F33ESTROGENDY - Days Enrollment to F33 Estrogen or Estrogen Combo

Col 61

N	Missing	Min	Max	Mean	StdDev
879	35,403	2,168	5,529	3,700.801	647.184

F33GALL - F33 Gallbladder Disease

Col 62

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	33,459	92.2
1	Yes	2,760	7.6
	Missing	63	0.2%

F33GALLDY - Days enrollment to F33 Gallbladder Disease

Col 63

N	Missing	Min	Max	Mean	StdDev
2,760	33,522	77	3,482	1,372.201	814.75

F33GLAUCOMA - F33 Glaucoma

Col 64

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	32,214	88.8
1	Yes	4,005	11
	Missing	63	0.2%

F33GLAUCOMADY - Days enrollment to F33 Glaucoma

Col 65

N	Missing	Min	Max	Mean	StdDev
4,005	32,277	88	3,448	1,457.226	817.542

F33OSTEOP - F33 Osteoporosis

Col 66

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	28,514	78.6
1	Yes	7,705	21.2
	Missing	63	0.2%

F33OSTEOPDY - Days enrollment to F33 Osteoporosis

Col 67

N	Missing	Min	Max	Mean	StdDev
7,705	28,577	70	3,496	1,394.272	781.105

F33OSTEOAR - F33 Osteoarthritis

Col 68

Usage Notes:

Not collected on all versions of F33.

Value	Description	N	%
0	No	20,641	56.9
1	Yes	15,574	42.9
	Missing	67	0.2%

F33OSTEOARDY - Days enrollment to F33 Osteoarthritis

Col 69

N	Missing	Min	Max	Mean	StdDev
15,574	20,708	69	5,495	1,913.373	1,313.963

F33RHEUM - F33 Rheumatoid Arthritis

Col 70

Usage Notes:

Not collected after WHI study closeout.

Value	Description	N	%
0	No	34,090	94
1	Yes	2,129	5.9
	Missing	63	0.2%

F33RHEUMDY - Days enrollment to F33 Rheumatoid Arthritis

Col 71

N	Missing	Min	Max	Mean	StdDev
2,129	34,153	112	3,480	1,367.962	813.335

F33INTPOLYP - F33 Intestinal Polyps

Col 72

Value	Description	N	%
0	No	27,561	76
1	Yes	8,658	23.9
	Missing	63	0.2%

F33INTPOLYPDY - Days enrollment to F33 Intestinal Polyps

Col 73

N	Missing	Min	Max	Mean	StdDev
8,658	27,624	62	5,440	2,186.854	1,275.574

F33KIDNEYST - F33 Kidney Stones

Col 74

Usage Notes:

Not collected after WHI study closeout. Not collected on all versions of F33.

Value	Description	N	%
0	No	35,310	97.3
1	Yes	833	2.3
	Missing	139	0.4%

F33KIDNEYSTDY - Days enrollment to F33 Kidney Stones

Col 75

N	Missing	Min	Max	Mean	StdDev
833	35,449	93	3,476	1,641.413	787.14

F33LUPUS - F33 Lupus

Col 76

Value	Description	N	%
0	No	35,719	98.4
1	Yes	500	1.4
	Missing	63	0.2%

F33LUPUSDY - Days enrollment to F33 Lupus

Col 77

N	Missing	Min	Max	Mean	StdDev
500	35,782	130	5,354	2,141.67	1,357.117

F33CATARACT - F33 Cataracts

Col 78

Usage Notes:

Not collected after WHI study closeout. Not collected on all versions of F33.

Value	Description	N	%
0	No	23,368	64.4
1	Yes	12,775	35.2
	Missing	139	0.4%

F33CATARACTDY - Days enrollment to F33 Cataracts

Col 79

N	Missing	Min	Max	Mean	StdDev
12,775	23,507	61	3,479	1,361.565	795.051

F33PARKINSONS - F33 Parkinsons

Col 80

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	29,549	81.4
1	Yes	313	0.9
	Missing	6,420	17.7%

F33PARKINSONSDY - Days enrollment to F33 Parkinsons

Col 81

N	Missing	Min	Max	Mean	StdDev
313	35,969	2,389	5,347	3,797.77	648.857

F33ALZHEIMERS - F33 Alzheimers

Col 82

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	28,517	78.6
1	Yes	1,345	3.7
	Missing	6,420	17.7%

F33ALZHEIMERSDY - Days enrollment to F33 Alzheimers

Col 83

N	Missing	Min	Max	Mean	StdDev
1,345	34,937	2,158	5,496	3,900.045	685.408

F33MACDEGEN - F33 Macular Degeneration

Col 84

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	27,901	76.9
1	Yes	1,961	5.4
	Missing	6,420	17.7%

F33MACDEGENDY - Days enrollment to F33 Macular Degeneration

Col 85

N	Missing	Min	Max	Mean	StdDev
1,961	34,321	2,053	5,457	3,729.069	669.936

LAST33WHIDY - Days enrollment to last WHI Form 33/33D

Col 86

Usage Notes:

LAST33WHIDY is calculated as the days from enrollment to the latest Form 33 in the WHI study. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33WHIDY.

N	Missing	Min	Max	Mean	StdDev
36,221	61	75	3,548	2,574.486	508.28

LAST33EXT1DY - Days enrollment to last Ext1 Form 33/33D

Col 87

Usage Notes:

LAST33EXT1DY is calculated as the days from enrollment to the latest Form 33 in the Extension Study 1. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33EXT1DY.

N	Missing	Min	Max	Mean	StdDev
29,661	6,621	1,986	5,573	4,464.369	471.175

F33HOSPWHI - F33 Hospitalized Ever in WHI

Col 88

Value	Description	N	%
0	No	19,288	53.2
1	Yes	16,994	46.8

F33HOSPX1 - Hospitalized ever in Ext1

Col 89

Value	Description	N	%
0	No	18,130	50
1	Yes	11,531	31.8
	Missing	6,621	18.2%

F33HOSPTIMESWHI - F33 Number of Hospitalizations in WHI

Col 90

Value	Description	N	%
0	0	19,227	53
1	1	8,220	22.7
2	2	4,029	11.1
3	3 or more	4,745	13.1
	Missing	61	0.2%

F33HOSPTIMESX1 - F33 Number of Hospitalizations in Ext1

Col 91

Value	Description	N	%
0	0	18,130	50
1	1	6,290	17.3
2	2	2,811	7.7
3	3 or more	2,430	6.7
	Missing	6,621	18.2%