This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Form 82 - Endometrial Aspiration

File Name	Data as of	Population	Data collected	One row per	Rows
f82_ht_inv.dat	9/12/2005	HT E+P	Baseline, Main	Form	22,986

ID - WHI Participant Common ID

Col 1

N	Missing
22,986	0

F82DAYS - F82 Days since randomization

Col 2

Days between randomization and initiation of form

N	Missing	Min	Max	Mean	StdDev
22,986	0	-272	3,367	264.928	606.208

F82VTYP - Visit Type

Col 3

Value	Description	N	%
1	Screening	16,607	72.2
2	Semi-Annual visit	384	1.7
3	Annual visit	2,790	12.1
4	Non-Routine visit	3,205	13.9

F82VY - Visit year

Col 4

Visit year for which this form was collected.

N	Missing	Min	Max	Mean	StdDev
19,781	3,205	0	9	0.502	1.339

F82VCLO - Closest to visit within visit type and year

Col 5

For forms entered with the same visit type and year, indicates the one closest to that visit's target date. Valid for forms entered with an annual visit type.

Usage Notes:

See data preparation document.

Value	Description	N	%
0	No	3,233	14.1
1	Yes	19,753	85.9

F82EXPC - Expected for visit

Col 6

This form/data was expected for this visit. Form 82 (Endometrial Aspiration) was expected at Baseline for all Estrogen plus Progestin (E+P) participants, and at years 3, 6, and 9 for a subsample of E+P participants as long as they did not have a hysterectomy. Endometrial aspirations were not expected after E+P study closure on 07/08/2002.

Usage Notes:

This includes forms from the subsample of OS participants at year 6 that were enrolled in the three clinical centers participating in the WHI Osteoporosis sub study, as height and weight were collected on OS participants at year 6 by design; see table 16.1; on page 16-18b of volume 2.

Value	Description	N	%
0	No	5,510	24
1	Yes	17,476	76

ENDODY - Days from randomization to endometrial aspiration

Col 7

N	Missing	Min	Max	Mean	StdDev
22,956	30	-465	3,342	257.926	601.644

EAPOSS - EA - Entry possible

Col 8

Was entry into uterus possible?

Value	Description	N	%
1	Yes	20,450	89
2	No, entry into the uterus not possible	2,300	10
3	No, participant refused	72	0.3
4	No, other	34	0.1
5	No, D&C results obtained	58	0.3
	Missing	72	0.3%

EADEPTH - Depth of uterus (cm)

Col 9

N	Missing	Min	Max	Mean	StdDev
19,556	3,430	2	15	6.594	1.123

EAFLUID - Significant cavity fluid

Col 10

Was significant endometrial cavity fluid found?

Usage Notes:

Not collected on all versions of Form 82.

Value	Description	N	%
0	No	18,714	81.4
1	Yes	411	1.8
	Missing	3,861	16.8%

EAREVDY - Days from randomization to endometrial aspiration report review

Col 11

N	Missing	Min	Max	Mean	StdDev
20,504	2,482	-481	3,367	288.082	610.773

EASUMM - Summary of endometrial aspiration report

Col 12

Value	Description	N	%
0	No endometrial tissue identified	2,815	12.2
1	Insufficient specimen	4,193	18.2
2	Normal atrophic endometrium	10,733	46.7
3	Normal secretory endometrium	307	1.3
4	Normal proliferative endometrium	1,970	8.6
5	Cystic (simple) hyperplasia present	106	0.5
6	Cystic (simple) hyperplasia with atypia	5	0
7	Adenomatous hyperplasia present	22	0.1
8	Adenomatous hyperplasia with atypia	12	0.1
9	Atypia present	21	0.1
10	Cancer present	19	0.1
11	Other	350	1.5
	Missing	2,433	10.6%

EAREFER - Endometrial Aspiration - Referral made for follow-up care

Col 13

Was a referral made for follow-up care (EA)?

Value	Description	N	%
0	No	19,445	84.6
1	Yes	440	1.9
	Missing	3,101	13.5%

EAREFDY - Days from randomization to endometrial aspiration referral

Col 14

Usage Notes:

Sub-question of F82 V2 Q13 "Referral made".

N	Missing	Min	Max	Mean	StdDev
407	22,579	-185	2,976	1,045.56	773.671

EAFURES - Endometrial aspiration follow-up results

Col 15

Endometiral aspiration follow-up results

Usage Notes:

Sub-question of F82 V2 Q13 "Referral made".

Value	Description	N	%
0	Normal	212	0.9
1	Hyperplasia	23	0.1
2	Cancer	19	0.1
	Missing	22,732	98.9%

CNTRDY - Days from randomization to central lab endometrial aspiration review

Col 16

N	Missing	Min	Max	Mean	StdDev
1,026	21,960	-88	2,410	524.575	280.604

CNTRSUMM - Central lab endometrial aspiration report summary

Col 17

Summary of central lab endometrial aspiration report

Value	Description	N	%
0	No endometrial tissue identified	31	0.1
1	Insufficient specimen	233	1
2	Normal atrophic endometrium	39	0.2
3	Normal secretory endometrium	11	0
4	Normal proliferative endometrium	597	2.6
5	Cystic (simple) hyperplasia present	28	0.1
6	Cystic (simple) hyperplasia with atypia	0	0
7	Adenomatous hyperplasia present	16	0.1
8	Adenomatous hyperplasia with atypia	0	0
9	Atypia present	3	0
10	Cancer present	3	0
11	Other	62	0.3
	Missing	21,963	95.5%