This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Core Analyte Results

File Name	Data as of	Population	Data collected	One row per	Rows
core_ctos_inv.dat	2/17/2024	CT+OS	Baseline, Main	Specimen Draw	17,328

Performed on the CT 6% subsample (W1) at baseline, Years 1, 3, and 6, and on the OS Measurement Precision Study participants (W2 - 1% of OS participants) at baseline and Month 3. The 20 core analytes include: - Coagulation Factors (citrate plasma): Factor VII Ag (antigen), Factor VIIC (activity), Fibrinogen - Lipids (EDTA plasma): HDL, HDL-2, HDL-3, LDL, Lp(a), total cholesterol, triglyceride - Micronutrients (serum): Alpha carotene, beta-carotene, alpha-tocopherol, gamma tocopherol, beta-cryptoxanthine, lycopene, lutein + zeaxanthin, retinol - Metabolic (serum): glucose, insulin

ID - WHI Participant Common ID

Col 1

N	Missing
17,328	0

COREDAYS - Core Days since randomization/enrollment

Col 2

Number of days from randomization/enrollment to date of blood draw.

N	Missing	Min	Max	Mean	StdDev
17,328	0	-629	3,282	721.871	834.444

COREVTYP - Visit Type

Col 3

Value	Description	N	%
1	Screening	5,488	31.7
2	Semi-Annual visit	1	0
3	Annual visit	10,946	63.2
4	Non-Routine visit	893	5.2

COREVY - Visit year

Col 4

Visit year for which the draw used for core analytes was collected.

N	Missing	Min	Max	Mean	StdDev
16,435	893	0	6	2.109	2.237

COREVCLO - Closest to visit within visit type and year

Col 5

For data with the same visit type and year, indicates the data closest to that visit's target date. Valid for data entered with an annual or semi-annual visit type.

Usage Notes:

See data preparation document.

Value	Description	N	%
0	No	905	5.2
1	Yes	16,423	94.8

COREEXPC - Expected for visit

Col 6

This data was expected for this visit. Core Analytes were expected of CT participants in the blood subsample at baseline and at years 1, 3, and 6. Core Analytes were expected for OS participants in the OS Measurement Precision Study (OS-MPS) at baseline and at a non-routine visit between 1 and 180 days after enrollment.

Usage Notes:

This includes forms from the subsample of OS participants at year 6 that were enrolled in the three clinical centers participating in the WHI Osteoporosis sub study, as height and weight were collected on OS participants at year 6 by design; see table 16.1; on page 16-18b of volume 2.

Value	Description	N	%
0	No	3	0
1	Yes	17,325	100

DRAWTIME - Draw time

Col 7

Time blood was drawn in military time. Format HH24:MI (e.g. 13:20).

N	Missing
17,328	0

CFUGTIME - Centrifuge time

Col 8

Time that centrifuging of blood began in military time. Format HH24:MI (e.g. 13:20).

N	Missing
17,315	13

VIALTIME - Cryovial time

Col 9

Time blood placed into cryovials in military time. Format HH24:MI (e.g. 13:20).

N	Missing
17,317	11

FREZTIME - Freeze time

Col 10

Time cryovials placed in freezer in military time. Format HH24:MI (e.g. 13:20).

N	Missing
17,309	19

FASTHRS - Fasting hours

Col 11

Number of hours since had anything to eat or drink besides water before blood draw.

N	Missing	Min	Max	Mean	StdDev
17,303	25	0	41	13.169	1.728

VIGACT - Vigorous activity in last 8 hours

Col 12

Engaged in vigorous physical activity in last eight hours before blood draw.

Value	Description	N	%
0	No	17,048	98.4
1	Yes	246	1.4
	Missing	34	0.2%

ANTIINFL - Anti-inflammatory use in last 48 hours

Col 13

Took aspirin or anti-inflammatory agents in last 48 hours before blood draw.

Value	Description	N	%
0	No	12,404	71.6
1	Yes	4,870	28.1
	Missing	54	0.3%

LIPEMIC - Serum is lipemic

Col 14

For HRT and HRT + DM screening visit and annual visits. Serum is lipemic.

Value	Description	N	%
0	No	16,348	94.3
1	Yes	125	0.7
	Missing	855	4.9%

COREACAR - Core Alpha-Carotene (ug/ml)

Col 15

N	Missing	Min	Max	Mean	StdDev
17,237	91	0	1.499	0.078	0.076

COREATOC - Core Alpha-Tocopherol (ug/ml)

Col 16

N	Missing	Min	Max	Mean	StdDev
17,239	89	0.11	99.71	17.377	8.026

COREBCAR - Core Beta-Carotene (ug/ml)

Col 17

N	Missing	Min	Max	Mean	StdDev
17,236	92	0.001	7.323	0.323	0.333

COREBCXA - Core Beta-Cryptoxanthine (ug/ml)

Col 18

N	Missing	Min	Max	Mean	StdDev
17,237	91	0.003	3.849	0.106	0.113

COREF7AG - Core Factor VII Antigen, activity (%)

Col 19

N	Missing	Min	Max	Mean	StdDev
16,663	665	18	895	126.261	32.322

COREF7C - Core Factor VII concentration (%)

Col 20

N	Missing	Min	Max	Mean	StdDev
16,471	857	10	300	127.809	31.673

COREFIBR - Core Fibrinogen (mg/dl)

Col 21

N	Missing	Min	Max	Mean	StdDev
16,641	687	63	763	299.854	61.637

COREGLUC - Core Glucose (Mg/dl)

Col 22

N	Missing	Min	Max	Mean	StdDev
17,281	47	4	452	101.706	29.598

COREGTOC - Core Gamma-Tocopherol (ug/ml)

Col 23

N	Missing	Min	Max	Mean	StdDev
17,238	90	0.03	26.75	1.897	1.375

COREHDL2 - Core High-Density Lipoprotein-2 (Mg/dl)

Col 24

N	Missing	Min	Max	Mean	StdDev
16,965	363	2	77	18.237	7.984

COREHDL3 - Core High-Density Lipoprotein-3 (Mg/dl)

Col 25

N	Missing	Min	Max	Mean	StdDev
16,971	357	10	91	40.779	9.05

COREHDLC - Core HDL Cholesterol (Mg/dl)

Col 26

High-Density Lipoprotein Cholesterol

N	Missing	Min	Max	Mean	StdDev
17,255	73	18	142	59.015	15.442

COREINSU - Core Insulin (uIU/ml) (RIA method)

Col 27

Usage Notes:

The insulin test for the core analytes changed. The majority of insulin testing used the RIA method. Later testing, however, used an automated ES300 method. Therefore, insulin results are split into two separate variables, dependent on the method used, RIA or ES300. The ES300 and RIA methods gave comparable results at insulin levels that WHI participants were likely to have, but the correlation between the ES300 and RIA methods was less good when insulin values exceeded 60 uIU/ml.

N	Missing	Min	Max	Mean	StdDev
13,786	3,542	2.8	427.4	12.212	9.679

COREINSU2 - Core Insulin (uIU/ml) (automated ES300 method)

Col 28

Usage Notes:

N	Missing	Min	Max	Mean	StdDev
2,999	14,329	0.5	1,749	11.517	35.283

CORELDLC - Core LDL Cholesterol (Mg/dl)

Col 29

Low-Density Lipoprotein Cholesterol

N	Missing	Min	Max	Mean	StdDev
16,991	337	21	447	128.156	35.112

CORELPA - Core Apolipoprotein(a) (Mg/dl)

Col 30

N	Missing	Min	Max	Mean	StdDev
17,043	285	1	282	27.864	27.109

CORELYCP - Core Lycopene (ug/ml)

Col 31

N	Missing	Min	Max	Mean	StdDev
17,238	90	0.001	1.692	0.388	0.199

CORELZXA - Core Lutein and Zeaxanthin (ug/ml)

Col 32

N	Missing	Min	Max	Mean	StdDev
17,238	90	0.011	2.532	0.216	0.109

CORERETI - Core Retinol (ug/ml)

Col 33

N	Missing	Min	Max	Mean	StdDev
17,239	89	0.08	1.8	0.606	0.155

CORETCHO - Core Total Cholesterol (Mg/dl)

Col 34

N	Missing	Min	Max	Mean	StdDev
17,295	33	68	560	217.145	37.716

CORETRI - Core Triglyceride (Mg/dl)

Col 35

N	Missing	Min	Max	Mean	StdDev
17,295	33	26	2,660	152.186	87.862