This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Self-Reported Outcomes, Extension Study 2, SRC Participants

File Name	Data as of	Population	Data collected	One row per	Rows
outc_self_x2_src_inv.dat	2/17/2024	SRC	Ext2	Participant	71,251

A self report is only counted if the first report of that outcome occurred after the start of the extension 2 phase of the study.

ID - WHI Participant Common ID

Col 1

N	Missing	Min	Max	Mean	StdDev
71,251	0	100,001	299,995	200,065.604	57,737.29

F33DVT - F33 Deep Vein Thrombosis

Col 2

Inpatient or outpatient DVT.

Value	Description	N	%
0	No	67,913	95.3
1	Yes	3,338	4.7

F33DVTDY - F33 Days enrollment to F33 Deep Vein Thrombosis

Col 3

N	Missing	Min	Max	Mean	StdDev
3,338	67,913	4,713	10,703	7,317.445	1,437.437

F33PEHSP - F33 Hospitalized Pulmonary Embolism

Col 4

Value	Description	N	%
0	No	69,897	98.1
1	Yes	1,354	1.9

F33PEHSPDY - Days enrollment to F33 Hospitalized Pulmonary Embolism

Col 5

N	Missing	Min	Max	Mean	StdDev
1,354	69,897	4,733	10,880	7,035.647	1,301.898

F33PEOP - F33 Outpatient Pulmonary Embolism

Col 6

Value	Description	N	%
0	No	71,036	99.7
1	Yes	215	0.3

F33PEOPDY - Days enrollment to F33 Outpatient Pulmonary Embolism

Col 7

N	Missing	Min	Max	Mean	StdDev
215	71,036	4,733	10,376	7,295.135	1,358.939

F33VTEHOSP - F33 Hospitalized Blood Clot (DVT or PE)

Col 8

F33VTEHOSP is 1 if any of the individual outcomes included in F33VTEHOSP are 1, i.e., the participant has a first event for any of the individual outcomes during Ext 2.

Value	Description	N	%
0	No	68,857	96.6
1	Yes	2,394	3.4

F33VTEHOSPDY - Days enrollment to F33 Hospitalized Blood Clot

Col 9

N	Missing	Min	Max	Mean	StdDev
2,394	68,857	4,713	10,880	7,004.674	1,311.568

F33VTEOP - F33 Outpatient DVT or PE

Col 10

F33VTEOP is 1 if any of the individual outcomes included in F33VTEOP are 1, i.e., the participant has a first event for any of the individual outcomes during Ext 2.

Value	Description	N	%
0	No	69,671	97.8
1	Yes	1,580	2.2

F33VTEOPDY - Days enrollment to F33 Outpatient DVT or PE

Col 11

N	Missing	Min	Max	Mean	StdDev
1,580	69,671	4,730	10,381	7,088.7	1,260.251

F33MIHSP - F33 Hospitalized MI

Col 12

Value	Description	N	%
0	No	68,857	96.6
1	Yes	2,394	3.4

F33MIHSPDY - Days enrollment to F33 Hospitalized MI

Col 13

N	Missing	Min	Max	Mean	StdDev
2,394	68,857	4,474	10,753	7,002.14	1,267.936

F33MIOP - F33 Outpatient MI

Col 14

Usage Notes:

Outpatient MIs were only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	71,003	99.7
1	Yes	248	0.3

F33MIOPDY - Days enrollment to F33 Outpatient MI

Col 15

N	Missing	Min	Max	Mean	StdDev
248	71,003	4,760	10,261	7,188.98	1,269.926

F33CHFHOSP - F33 Hospitalized Heart Failure

Col 16

Value	Description	N	%
0	No	67,229	94.4
1	Yes	4,022	5.6

F33CHFHOSPDY - Days enrollment to F33 Hospitalized Heart Failure

Col 17

N	Missing	Min	Max	Mean	StdDev
4,022	67,229	4,713	10,942	7,166.354	1,304.007

F33CHFOP - F33 Outpatient CHF

Col 18

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	69,512	97.6
1	Yes	1,739	2.4

F33CHFOPDY - Days enrollment to F33 Outpatient CHF

Col 19

N	Missing	Min	Max	Mean	StdDev
1,739	69,512	4,733	10,608	7,532.357	1,316.671

F33CABGHSP - F33 Hospitalized CABG

Col 20

Value	Description	N	%
0	No	70,519	99
1	Yes	732	1

F33CABGHSPDY - Days enrollment to F33 Hospitalized CABG

Col 21

N	Missing	Min	Max	Mean	StdDev
732	70,519	4,713	10,583	6,563.033	1,183.034

F33CABGOP - F33 Outpatient CABG

Col 22

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	71,231	100
1	Yes	20	0

F33CABGOPDY - Days enrollment to F33 Outpatient CABG

Col 23

N	Missing	Min	Max	Mean	StdDev
20	71,231	5,032	8,387	6,890.55	1,075.321

F33PTCAHSP - F33 Hospitalized PTCA

Col 24

Value	Description	N	%
0	No	68,943	96.8
1	Yes	2,308	3.2

F33PTCAHSPDY - Days enrollment to F33 Hospitalized PTCA

Col 25

N	Missing	Min	Max	Mean	StdDev
2,308	68,943	4,474	10,899	6,857.196	1,241.391

F33PTCAOP - F33 Outpatient PTCA

Col 26

Value	Description	N	%
0	No	70,826	99.4
1	Yes	425	0.6

F33PTCAOPDY - Days enrollment to F33 Outpatient PTCA

Col 27

N	Missing	Min	Max	Mean	StdDev
425	70,826	4,743	10,595	7,190.581	1,288.661

F33CAROTIDHSP - F33 Hospitalized Carotid Endarterectomy

Col 28

Hospitalized for carotid endarterectomy, carotid angioplasty, or carotid stent.

Value	Description	N	%
0	No	70,490	98.9
1	Yes	761	1.1

F33CAROTIDHSPDY - Days enrollment to F33 Hospitalized Carotid Endarterectomy

Col 29

N	Missing	Min	Max	Mean	StdDev
761	70,490	4,718	10,395	6,801.79	1,214.392

F33CAROTIDOP - F33 Outpatient Carotid Endarterectomy

Col 30

Outpatient carotid endarterectomy, carotid angioplasty, or carotid stent.

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	71,118	99.8
1	Yes	133	0.2

F33CAROTIDOPDY - Days enrollment to F33 Outpatient Carotid Endarterectomy

Col 31

N	Missing	Min	Max	Mean	StdDev
133	71,118	4,739	10,595	6,842.233	1,335.339

F33PADHSP - F33 Hospitalized Peripheral Arterial Disease

Col 32

Hospitalized for poor blood circulation or any procedure to unblock narrowed arteries to legs or feet

Value	Description	N	%
0	No	70,313	98.7
1	Yes	938	1.3

F33PADHSPDY - Days enrollment to F33 Hospitalized Peripheral Arterial Disease

Col 33

N	Missing	Min	Max	Mean	StdDev
938	70,313	4,504	10,880	7,026.205	1,304.723

F33PADOP - F33 Outpatient Peripheral Arterial Disease

Col 34

Poor blood circulation or any procedure to unblock narrowed arteries to legs or feet

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	69,019	96.9
1	Yes	2,232	3.1

F33PADOPDY - Days enrollment to F33 Outpatient Peripheral Arterial Disease

Col 35

N	Missing	Min	Max	Mean	StdDev
2,232	69,019	4,713	10,827	7,134.715	1,289.285

F33HRTVLVHSP - F33 Hospitalized Heart Valve

Col 36

Hospitalized for heart valve problem or surgery

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	69,215	97.1
1	Yes	2,036	2.9

F33HRTVLVHSPDY - Days enrollment to F33 Hospitalized Heart Valve

Col 37

N	Missing	Min	Max	Mean	StdDev
2,036	69,215	4,714	10,631	7,103.102	1,304.318

F33HRTVLVOP - F33 Outpatient Heart Valve

Col 38

Outpatient heart valve problem or surgery

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	70,030	98.3
1	Yes	1,221	1.7

F33HRTVLVOPDY - Days enrollment to F33 Outpatient Heart Valve

Col 39

N	Missing	Min	Max	Mean	StdDev
1,221	70,030	4,733	10,595	7,167.9	1,304.751

F33AFIBHSP - F33 Hospitalized Atrial Fibrillation

Col 40

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	62,719	88
1	Yes	8,532	12

F33AFIBHSPDY - Days enrollment to F33 Hospitalized Atrial Fibrillation

Col 41

N	Missing	Min	Max	Mean	StdDev
8,532	62,719	4,451	10,669	6,838.925	1,242.035

F33AFIBOP - F33 Outpatient Atrial Fibrillation

Col 42

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	64,059	89.9
1	Yes	7,192	10.1

F33AFIBOPDY - Days enrollment to F33 Outpatient Atrial Fibrillation

Col 43

N	Missing	Min	Max	Mean	StdDev
7,192	64,059	4,711	10,756	7,053.006	1,260.643

F33AAAHSP - F33 Hospitalized Abdominal Aortic Aneurysm

Col 44

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	70,608	99.1
1	Yes	643	0.9

F33AAAHSPDY - Days enrollment to F33 Hospitalized Abdominal Aortic Aneurysm

Col 45

N	Missing	Min	Max	Mean	StdDev
643	70,608	4,713	10,336	6,768.285	1,229.762

F33AAAOP - F33 Outpatient Abdominal Aortic Aneurysm

Col 46

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	71,113	99.8
1	Yes	138	0.2

F33AAAOPDY - Days enrollment to F33 Outpatient Abdominal Aortic Aneurysm

Col 47

N	Missing	Min	Max	Mean	StdDev
138	71,113	4,780	10,191	7,048.319	1,169.136

F33STRKHSP - F33 Hospitalized Stroke

Col 48

Value	Description	N	%
0	No	66,384	93.2
1	Yes	4,867	6.8

F33STRKHSPDY - Days enrollment to F33 Hospitalized Stroke

Col 49

N	Missing	Min	Max	Mean	StdDev
4,867	66,384	4,714	10,942	7,424.057	1,399.357

F33STRKOP - F33 Outpatient Stroke

Col 50

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	70,299	98.7
1	Yes	952	1.3

F33STRKOPDY - Days enrollment to F33 Outpatient Stroke

Col 51

N	Missing	Min	Max	Mean	StdDev
952	70,299	4,597	10,658	7,475.709	1,440.423

F33ANGHOSP - F33 Hospitalized Angina

Col 52

Value	Description	N	%
0	No	65,212	91.5
1	Yes	6,039	8.5

F33ANGHOSPDY - Days enrollment to F33 Hospitalized Angina

Col 53

N	Missing	Min	Max	Mean	StdDev
6,039	65,212	4,713	10,898	7,239.005	1,423.447

F33COPD - F33 COPD

Col 54

COPD, emphysema, or chronic bronchitis

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	61,393	86.2
1	Yes	9,858	13.8

F33COPDDY - Days enrollment to F33 COPD

Col 55

N	Missing	Min	Max	Mean	StdDev
9,858	61,393	4,473	10,893	7,106.291	1,361.535

F33NMSC - F33 Non-Melanoma Skin Cancer

Col 56

Value	Description	N	%
0	No	65,797	92.3
1	Yes	5,454	7.7

F33NMSCDY - Days enrollment since F33 Non-Melanoma Skin Cancer

Col 57

N	Missing	Min	Max	Mean	StdDev
5,454	65,797	4,716	10,735	7,761.197	1,469.665

F33BKHIP - F33 Broken Hip

Col 58

Value	Description	N	%
0	No	66,394	93.2
1	Yes	4,857	6.8

F33BKHIPDY - Days enrollment to F33 Broken Hip

Col 59

N	Missing	Min	Max	Mean	StdDev
4,857	66,394	4,515	10,906	7,629.775	1,434.325

F33BKULEG - F33 Broken Upper Leg

Col 60

Value	Description	N	%
0	No	68,787	96.5
1	Yes	2,464	3.5

F33BKULEGDY - Days enrollment to F33 Broken Upper Leg

Col 61

N	Missing	Min	Max	Mean	StdDev
2,464	68,787	4,471	10,619	7,607.859	1,448.1

F33BKPELV - F33 Broken Pelvis

Col 62

Value	Description	N	%
0	No	68,812	96.6
1	Yes	2,439	3.4

F33BKPELVDY - Days enrollment to F33 Broken Pelvis

Col 63

N	Missing	Min	Max	Mean	StdDev
2,439	68,812	4,715	10,576	7,433.816	1,423.61

F33BKKNEE - F33 Broken Knee

Col 64

Value	Description	N	%
0	No	69,503	97.5
1	Yes	1,748	2.5

F33BKKNEEDY - Days enrollment to F33 Broken Knee

Col 65

N	Missing	Min	Max	Mean	StdDev
1,748	69,503	4,718	10,576	7,268.295	1,425.578

F33BKSPINE - F33 Broken Spine

Col 66

Value	Description	N	%
0	No	66,214	92.9
1	Yes	5,037	7.1

F33BKSPINEDY - Days enrollment to F33 Broken Spine

Col 67

N	Missing	Min	Max	Mean	StdDev
5,037	66,214	4,715	10,963	7,346.279	1,471.047

F33BKUARM - F33 Broken Upper Arm

Col 68

Value	Description	N	%
0	No	67,386	94.6
1	Yes	3,865	5.4

F33BKUARMDY - Days enrollment to F33 Broken Upper Arm

Col 69

N	Missing	Min	Max	Mean	StdDev
3,865	67,386	4,711	10,906	7,416.524	1,454.284

F33BKLARM - F33 Broken Lower Arm

Col 70

Value	Description	N	%
0	No	66,677	93.6
1	Yes	4,574	6.4

F33BKLARMDY - Days enrollment to F33 Broken Lower Arm

Col 71

N	Missing	Min	Max	Mean	StdDev
4,574	66,677	4,667	10,773	7,275.528	1,405.226

F33BKHAND - F33 Broken Hand

Col 72

Value	Description	N	%
0	No	70,197	98.5
1	Yes	1,054	1.5

F33BKHANDDY - Days enrollment to F33 Broken Hand

Col 73

N	Missing	Min	Max	Mean	StdDev
1,054	70,197	4,712	10,669	7,227.999	1,390.021

F33BKLLEG - F33 Broken Lower Leg

Col 74

Value	Description	N	%
0	No	68,373	96
1	Yes	2,878	4

F33BKLLEGDY - Days enrollment to F33 Broken Lower Leg

Col 75

N	Missing	Min	Max	Mean	StdDev
2,878	68,373	4,710	10,614	7,164.781	1,413.291

F33BKFOOT - F33 Broken Foot

Col 76

Value	Description	N	%
0	No	68,561	96.2
1	Yes	2,690	3.8

F33BKFOOTDY - Days enrollment to F33 Broken Foot

Col 77

N	Missing	Min	Max	Mean	StdDev
2,690	68,561	4,646	10,603	7,084.559	1,365.331

F33BKTAILBN - F33 Broken Tailbone

Col 78

Value	Description	N	%
0	No	70,386	98.8
1	Yes	865	1.2

F33BKTAILBNDY - Days enrollment to F33 Broken Tailbone

Col 79

N	Missing	Min	Max	Mean	StdDev
865	70,386	4,719	10,563	7,338.052	1,423.55

F33BKELBOW - F33 Broken Elbow

Col 80

Value	Description	N	%
0	No	70,131	98.4
1	Yes	1,120	1.6

F33BKELBOWDY - Days enrollment to F33 Broken Elbow

Col 81

N	Missing	Min	Max	Mean	StdDev
1,120	70,131	4,729	10,667	7,314.867	1,435.516

F33BKOTHBNX2 - F33 Broken Other Bone

Col 82

Broken other bone, Extension 2 definition.

Usage Notes:

This variable does not map to the Broken Other Bone (F33BKOTHBN) variable collected prior to Extension Study 2, as the form question changed.

Value	Description	N	%
0	No	62,109	87.2
1	Yes	9,142	12.8

F33BKOTHBNX2DY - Days enrollment to F33 Broken Other Bone

Col 83

N	Missing	Min	Max	Mean	StdDev
9,142	62,109	4,581	10,932	7,172.7	1,409.363

F33ANYFXNONHIP - F33 Any Non-Hip Fracture

Col 84

Any fracture except hip (includes other bone).

Usage Notes:

F33ANYFXNONHIP is 1 if the participant has a first event for any of the individual fracture outcomes during Ext 2

Value	Description	N	%
0	No	45,524	63.9
1	Yes	25,727	36.1

F33ANYFXNONHIPDY - Days enrollment to F33 Any Non-Hip Fracture

Col 85

Usage Notes:

Earliest F33 non-hip fracture.

N	Missing	Min	Max	Mean	StdDev
25,727	45,524	4,471	10,963	7,041.112	1,406.415

F33HYST - F33 Hysterectomy Ever

Col 86

Value	Description	N	%
0	No	69,052	96.9
1	Yes	2,199	3.1

F33HYSTDY - Days enrollment to F33 Hysterectomy Ever

Col 87

N	Missing	Min	Max	Mean	StdDev
2,199	69,052	4,709	10,584	7,073.54	1,371.522

F33OSTEOAR - F33 Osteoarthritis

Col 88

Usage Notes:

Not collected on all versions of F33.

Value	Description	N	%
0	No	51,285	72
1	Yes	19,966	28

F33OSTEOARDY - Days enrollment to F33 Osteoarthritis

Col 89

N	Missing	Min	Max	Mean	StdDev
19,966	51,285	4,543	10,941	7,159.329	1,338.569

F33INTPOLYP - F33 Intestinal Polyps

Col 90

Value	Description	N	%
0	No	63,519	89.1
1	Yes	7,732	10.9

F33INTPOLYPDY - Days enrollment to F33 Intestinal Polyps

Col 91

N	Missing	Min	Max	Mean	StdDev
7,732	63,519	4,558	10,631	6,955.228	1,345.298

F33LUPUS - F33 Lupus

Col 92

Value	Description	N	%
0	No	70,872	99.5
1	Yes	379	0.5

F33LUPUSDY - Days enrollment to F33 Lupus

Col 93

N	Missing	Min	Max	Mean	StdDev
379	70,872	4,733	9,092	6,815.293	999.921

F33PILLSHYP - F33 Pills For Hypertension

Col 94

Value	Description	N	%
0	No	60,387	84.8
1	Yes	10,864	15.2

F33PILLSHYPDY - Days enrollment to F33 Pills For Hypertension

Col 95

N	Missing	Min	Max	Mean	StdDev
10,864	60,387	4,447	10,803	7,112.738	1,475.637

F33DIABTX - F33 Diabetes Treated

Col 96

Usage Notes:

Pills or insulin shots.

Value	Description	N	%
0	No	61,284	86
1	Yes	9,967	14

F33DIABTXDY - Days enrollment to F33 Diabetes Treated

Col 97

N	Missing	Min	Max	Mean	StdDev
9,967	61,284	4,451	10,875	7,549.015	1,499.854

F33DIABINSULIN - F33 Diabetes Insulin

Col 98

Value	Description	N	%
0	No	69,400	97.4
1	Yes	1,851	2.6

F33DIABINSULINDY - Days enrollment to F33 Diabetes Insulin

Col 99

N	Missing	Min	Max	Mean	StdDev
1,851	69,400	4,577	10,620	7,326.789	1,412.84

F33DIABPILLS - F33 Diabetes Pills

Col 100

Value	Description	N	%
0	No	61,467	86.3
1	Yes	9,784	13.7

F33DIABPILLSDY - Days enrollment to F33 Diabetes Pills

Col 101

N	Missing	Min	Max	Mean	StdDev
9,784	61,467	4,451	10,875	7,556.58	1,500.53

F33DIABDIEX - F33 Diabetes Diet and/or Exercise

Col 102

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	60,989	85.6
1	Yes	10,262	14.4

F33DIABDIEXDY - Days enrollment to Diabetes Diet and/or Exercise

Col 103

N	Missing	Min	Max	Mean	StdDev
10,262	60,989	4,714	10,930	7,178.453	1,427.445

F33PARKINSONS - F33 Parkinsons

Col 104

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	69,572	97.6
1	Yes	1,679	2.4

F33PARKINSONSDY - Days enrollment to F33 Parkinsons

Col 105

N	Missing	Min	Max	Mean	StdDev
1,679	69,572	4,715	10,770	7,391.962	1,415.448

F33ALZHEIMERS - F33 Moderate or severe memory problems, dementia or Alzheimers

Col 106

Moderate or severe memory problems, dementia or Alzheimers

Usage Notes:

For version 13 of Form 33, this is a 1 if either “Moderate or severe memory problems” or “Dementia or Alzheimer’s” questions are marked. Prior to version 13 this was a single question "Moderate or severe memory problems (dementia or Alzheimers)"

Value	Description	N	%
0	No	55,304	77.6
1	Yes	15,947	22.4

F33ALZHEIMERSDY - Days enrollment to F33 Alzheimers

Col 107

N	Missing	Min	Max	Mean	StdDev
15,947	55,304	4,524	10,906	7,905.629	1,422.27

F33MACDEGEN - F33 Macular Degeneration

Col 108

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	56,648	79.5
1	Yes	14,603	20.5

F33MACDEGENDY - Days enrollment to F33 Macular Degeneration

Col 109

N	Missing	Min	Max	Mean	StdDev
14,603	56,648	4,549	10,906	7,364.619	1,405.58

LAST33DY - Days enrollment to last form 33/33D

Col 110

Days from enrollment to last contact for outcomes information.

Usage Notes:

LAST33DY is calculated as the days from enrollment to the latest Form 33 during Extension Study 2. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33DY. LAST33DY may be missing if the ppt had no form 33s entered for extension 2.

N	Missing	Min	Max	Mean	StdDev
70,201	1,050	4,471	10,978	8,731.999	1,450.174

F33HOSPX2 - F33 Hospitalized During Extension Study 2

Col 111

Value	Description	N	%
0	No	21,944	30.8
1	Yes	49,307	69.2

F33HOSPTIMESX2 - F33 Number of Hospitalizations During Extension Study 2

Col 112

Value	Description	N	%
0	None	21,944	30.8
1	One	13,809	19.4
2	Two	11,111	15.6
3	Three or more	24,387	34.2