This document can be used to prepare or evaluate feasibility of ancillary study proposals and paper proposals, but is NOT intended for publication.

Self-Reported Outcomes, Extension Study 2, SRC Participants

File Name	Data as of	Population	Data collected	One row per	Rows
outc_self_x2_src_inv.dat	2/15/2025	SRC	Ext2	Participant	71,251

A self report is only counted if the first report of that outcome occurred after the start of the extension 2 phase of the study.

ID - WHI Participant Common ID

Col 1

N	Missing	Min	Max	Mean	StdDev
71,251	0	100,001	299,995	200,065.604	57,737.29

F33DVT - F33 Deep Vein Thrombosis

Col 2

Inpatient or outpatient DVT.

Value	Description	N	%
0	No	67,742	95.1
1	Yes	3,509	4.9

F33DVTDY - F33 Days enrollment to F33 Deep Vein Thrombosis

Col 3

N	Missing	Min	Max	Mean	StdDev
3,509	67,742	4,713	10,938	7,452.052	1,527.253

F33PEHSP - F33 Hospitalized Pulmonary Embolism

Col 4

Value	Description	N	%
0	No	69,854	98
1	Yes	1,397	2

F33PEHSPDY - Days enrollment to F33 Hospitalized Pulmonary Embolism

Col 5

N	Missing	Min	Max	Mean	StdDev
1,397	69,854	4,733	10,919	7,138.654	1,394.283

F33PEOP - F33 Outpatient Pulmonary Embolism

Col 6

Value	Description	N	%
0	No	71,020	99.7
1	Yes	231	0.3

F33PEOPDY - Days enrollment to F33 Outpatient Pulmonary Embolism

Col 7

N	Missing	Min	Max	Mean	StdDev
231	71,020	4,733	10,624	7,422.671	1,434.891

F33VTEHOSP - F33 Hospitalized Blood Clot (DVT or PE)

Col 8

F33VTEHOSP is 1 if any of the individual outcomes included in F33VTEHOSP are 1, i.e., the participant has a first event for any of the individual outcomes during Ext 2.

Value	Description	N	%
0	No	68,779	96.5
1	Yes	2,472	3.5

F33VTEHOSPDY - Days enrollment to F33 Hospitalized Blood Clot

Col 9

N	Missing	Min	Max	Mean	StdDev
2,472	68,779	4,713	10,928	7,108.328	1,405.9

F33VTEOP - F33 Outpatient DVT or PE

Col 10

F33VTEOP is 1 if any of the individual outcomes included in F33VTEOP are 1, i.e., the participant has a first event for any of the individual outcomes during Ext 2.

Value	Description	N	%
0	No	69,614	97.7
1	Yes	1,637	2.3

F33VTEOPDY - Days enrollment to F33 Outpatient DVT or PE

Col 11

N	Missing	Min	Max	Mean	StdDev
1,637	69,614	4,730	10,781	7,179.866	1,342.283

F33MIHSP - F33 Hospitalized MI

Col 12

Value	Description	N	%
0	No	68,774	96.5
1	Yes	2,477	3.5

F33MIHSPDY - Days enrollment to F33 Hospitalized MI

Col 13

N	Missing	Min	Max	Mean	StdDev
2,477	68,774	4,474	11,073	7,102.836	1,367.884

F33MIOP - F33 Outpatient MI

Col 14

Usage Notes:

Outpatient MIs were only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	70,986	99.6
1	Yes	265	0.4

F33MIOPDY - Days enrollment to F33 Outpatient MI

Col 15

N	Missing	Min	Max	Mean	StdDev
265	70,986	4,760	11,022	7,341.26	1,396.182

F33CHFHOSP - F33 Hospitalized Heart Failure

Col 16

Value	Description	N	%
0	No	67,095	94.2
1	Yes	4,156	5.8

F33CHFHOSPDY - Days enrollment to F33 Hospitalized Heart Failure

Col 17

N	Missing	Min	Max	Mean	StdDev
4,156	67,095	4,713	11,102	7,263.938	1,387.686

F33CHFOP - F33 Outpatient CHF

Col 18

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	69,419	97.4
1	Yes	1,832	2.6

F33CHFOPDY - Days enrollment to F33 Outpatient CHF

Col 19

N	Missing	Min	Max	Mean	StdDev
1,832	69,419	4,733	10,990	7,660.193	1,405.623

F33CABGHSP - F33 Hospitalized CABG

Col 20

Value	Description	N	%
0	No	70,510	99
1	Yes	741	1

F33CABGHSPDY - Days enrollment to F33 Hospitalized CABG

Col 21

N	Missing	Min	Max	Mean	StdDev
741	70,510	4,713	10,640	6,595.95	1,227.491

F33CABGOP - F33 Outpatient CABG

Col 22

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	71,226	100
1	Yes	25	0

F33CABGOPDY - Days enrollment to F33 Outpatient CABG

Col 23

N	Missing	Min	Max	Mean	StdDev
25	71,226	5,032	10,561	7,156.44	1,399.658

F33PTCAHSP - F33 Hospitalized PTCA

Col 24

Value	Description	N	%
0	No	68,893	96.7
1	Yes	2,358	3.3

F33PTCAHSPDY - Days enrollment to F33 Hospitalized PTCA

Col 25

N	Missing	Min	Max	Mean	StdDev
2,358	68,893	4,474	11,073	6,930.039	1,321.041

F33PTCAOP - F33 Outpatient PTCA

Col 26

Value	Description	N	%
0	No	70,813	99.4
1	Yes	438	0.6

F33PTCAOPDY - Days enrollment to F33 Outpatient PTCA

Col 27

N	Missing	Min	Max	Mean	StdDev
438	70,813	4,743	10,989	7,272.852	1,362.874

F33CAROTIDHSP - F33 Hospitalized Carotid Endarterectomy

Col 28

Hospitalized for carotid endarterectomy, carotid angioplasty, or carotid stent.

Value	Description	N	%
0	No	70,476	98.9
1	Yes	775	1.1

F33CAROTIDHSPDY - Days enrollment to F33 Hospitalized Carotid Endarterectomy

Col 29

N	Missing	Min	Max	Mean	StdDev
775	70,476	4,718	10,599	6,867.569	1,291.087

F33CAROTIDOP - F33 Outpatient Carotid Endarterectomy

Col 30

Outpatient carotid endarterectomy, carotid angioplasty, or carotid stent.

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	71,113	99.8
1	Yes	138	0.2

F33CAROTIDOPDY - Days enrollment to F33 Outpatient Carotid Endarterectomy

Col 31

N	Missing	Min	Max	Mean	StdDev
138	71,113	4,739	10,707	6,955.819	1,416.114

F33PADHSP - F33 Hospitalized Peripheral Arterial Disease

Col 32

Hospitalized for poor blood circulation or any procedure to unblock narrowed arteries to legs or feet

Value	Description	N	%
0	No	70,285	98.6
1	Yes	966	1.4

F33PADHSPDY - Days enrollment to F33 Hospitalized Peripheral Arterial Disease

Col 33

N	Missing	Min	Max	Mean	StdDev
966	70,285	4,504	11,080	7,101.318	1,387.572

F33PADOP - F33 Outpatient Peripheral Arterial Disease

Col 34

Poor blood circulation or any procedure to unblock narrowed arteries to legs or feet

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	68,935	96.7
1	Yes	2,316	3.3

F33PADOPDY - Days enrollment to F33 Outpatient Peripheral Arterial Disease

Col 35

N	Missing	Min	Max	Mean	StdDev
2,316	68,935	4,713	11,194	7,236.282	1,381.258

F33HRTVLVHSP - F33 Hospitalized Heart Valve

Col 36

Hospitalized for heart valve problem or surgery

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	69,150	97.1
1	Yes	2,101	2.9

F33HRTVLVHSPDY - Days enrollment to F33 Hospitalized Heart Valve

Col 37

N	Missing	Min	Max	Mean	StdDev
2,101	69,150	4,714	10,941	7,192.328	1,385.706

F33HRTVLVOP - F33 Outpatient Heart Valve

Col 38

Outpatient heart valve problem or surgery

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	69,978	98.2
1	Yes	1,273	1.8

F33HRTVLVOPDY - Days enrollment to F33 Outpatient Heart Valve

Col 39

N	Missing	Min	Max	Mean	StdDev
1,273	69,978	4,733	10,912	7,281.391	1,400.092

F33AFIBHSP - F33 Hospitalized Atrial Fibrillation

Col 40

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	62,542	87.8
1	Yes	8,709	12.2

F33AFIBHSPDY - Days enrollment to F33 Hospitalized Atrial Fibrillation

Col 41

N	Missing	Min	Max	Mean	StdDev
8,709	62,542	4,451	11,211	6,906.255	1,315.903

F33AFIBOP - F33 Outpatient Atrial Fibrillation

Col 42

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	63,844	89.6
1	Yes	7,407	10.4

F33AFIBOPDY - Days enrollment to F33 Outpatient Atrial Fibrillation

Col 43

N	Missing	Min	Max	Mean	StdDev
7,407	63,844	4,711	11,211	7,142.72	1,349.949

F33AAAHSP - F33 Hospitalized Abdominal Aortic Aneurysm

Col 44

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	70,601	99.1
1	Yes	650	0.9

F33AAAHSPDY - Days enrollment to F33 Hospitalized Abdominal Aortic Aneurysm

Col 45

N	Missing	Min	Max	Mean	StdDev
650	70,601	4,713	10,651	6,849.812	1,317.014

F33AAAOP - F33 Outpatient Abdominal Aortic Aneurysm

Col 46

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	71,106	99.8
1	Yes	145	0.2

F33AAAOPDY - Days enrollment to F33 Outpatient Abdominal Aortic Aneurysm

Col 47

N	Missing	Min	Max	Mean	StdDev
145	71,106	4,780	10,694	7,197.441	1,328.404

F33STRKHSP - F33 Hospitalized Stroke

Col 48

Value	Description	N	%
0	No	66,098	92.8
1	Yes	5,153	7.2

F33STRKHSPDY - Days enrollment to F33 Hospitalized Stroke

Col 49

N	Missing	Min	Max	Mean	StdDev
5,153	66,098	4,714	11,144	7,607.146	1,511.146

F33STRKOP - F33 Outpatient Stroke

Col 50

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	70,264	98.6
1	Yes	987	1.4

F33STRKOPDY - Days enrollment to F33 Outpatient Stroke

Col 51

N	Missing	Min	Max	Mean	StdDev
987	70,264	4,597	11,051	7,627.815	1,525.568

F33ANGHOSP - F33 Hospitalized Angina

Col 52

Value	Description	N	%
0	No	64,951	91.2
1	Yes	6,300	8.8

F33ANGHOSPDY - Days enrollment to F33 Hospitalized Angina

Col 53

N	Missing	Min	Max	Mean	StdDev
6,300	64,951	4,713	11,103	7,361.101	1,514.791

F33COPD - F33 COPD

Col 54

COPD, emphysema, or chronic bronchitis

Usage Notes:

Only collected during the WHI Extension Study 2.

Value	Description	N	%
0	No	61,087	85.7
1	Yes	10,164	14.3

F33COPDDY - Days enrollment to F33 COPD

Col 55

N	Missing	Min	Max	Mean	StdDev
10,164	61,087	4,473	11,044	7,197.367	1,438.788

F33NMSC - F33 Non-Melanoma Skin Cancer

Col 56

Value	Description	N	%
0	No	65,410	91.8
1	Yes	5,841	8.2

F33NMSCDY - Days enrollment since F33 Non-Melanoma Skin Cancer

Col 57

N	Missing	Min	Max	Mean	StdDev
5,841	65,410	4,716	11,270	7,921.258	1,545.472

F33BKHIP - F33 Broken Hip

Col 58

Value	Description	N	%
0	No	66,030	92.7
1	Yes	5,221	7.3

F33BKHIPDY - Days enrollment to F33 Broken Hip

Col 59

N	Missing	Min	Max	Mean	StdDev
5,221	66,030	4,515	11,296	7,805.754	1,531.377

F33BKULEG - F33 Broken Upper Leg

Col 60

Value	Description	N	%
0	No	68,588	96.3
1	Yes	2,663	3.7

F33BKULEGDY - Days enrollment to F33 Broken Upper Leg

Col 61

N	Missing	Min	Max	Mean	StdDev
2,663	68,588	4,471	10,961	7,794.784	1,543.018

F33BKPELV - F33 Broken Pelvis

Col 62

Value	Description	N	%
0	No	68,675	96.4
1	Yes	2,576	3.6

F33BKPELVDY - Days enrollment to F33 Broken Pelvis

Col 63

N	Missing	Min	Max	Mean	StdDev
2,576	68,675	4,715	11,335	7,580.46	1,520.426

F33BKKNEE - F33 Broken Knee

Col 64

Value	Description	N	%
0	No	69,431	97.4
1	Yes	1,820	2.6

F33BKKNEEDY - Days enrollment to F33 Broken Knee

Col 65

N	Missing	Min	Max	Mean	StdDev
1,820	69,431	4,718	11,289	7,385.959	1,514.671

F33BKSPINE - F33 Broken Spine

Col 66

Value	Description	N	%
0	No	65,917	92.5
1	Yes	5,334	7.5

F33BKSPINEDY - Days enrollment to F33 Broken Spine

Col 67

N	Missing	Min	Max	Mean	StdDev
5,334	65,917	4,715	11,299	7,505.181	1,575.001

F33BKUARM - F33 Broken Upper Arm

Col 68

Value	Description	N	%
0	No	67,179	94.3
1	Yes	4,072	5.7

F33BKUARMDY - Days enrollment to F33 Broken Upper Arm

Col 69

N	Missing	Min	Max	Mean	StdDev
4,072	67,179	4,711	11,165	7,557.094	1,544.299

F33BKLARM - F33 Broken Lower Arm

Col 70

Value	Description	N	%
0	No	66,470	93.3
1	Yes	4,781	6.7

F33BKLARMDY - Days enrollment to F33 Broken Lower Arm

Col 71

N	Missing	Min	Max	Mean	StdDev
4,781	66,470	4,667	11,065	7,398.914	1,494.594

F33BKHAND - F33 Broken Hand

Col 72

Value	Description	N	%
0	No	70,142	98.4
1	Yes	1,109	1.6

F33BKHANDDY - Days enrollment to F33 Broken Hand

Col 73

N	Missing	Min	Max	Mean	StdDev
1,109	70,142	4,712	11,125	7,371.301	1,496.749

F33BKLLEG - F33 Broken Lower Leg

Col 74

Value	Description	N	%
0	No	68,232	95.8
1	Yes	3,019	4.2

F33BKLLEGDY - Days enrollment to F33 Broken Lower Leg

Col 75

N	Missing	Min	Max	Mean	StdDev
3,019	68,232	4,710	11,044	7,302.595	1,516.635

F33BKFOOT - F33 Broken Foot

Col 76

Value	Description	N	%
0	No	68,449	96.1
1	Yes	2,802	3.9

F33BKFOOTDY - Days enrollment to F33 Broken Foot

Col 77

N	Missing	Min	Max	Mean	StdDev
2,802	68,449	4,646	11,319	7,209.672	1,473.794

F33BKTAILBN - F33 Broken Tailbone

Col 78

Value	Description	N	%
0	No	70,329	98.7
1	Yes	922	1.3

F33BKTAILBNDY - Days enrollment to F33 Broken Tailbone

Col 79

N	Missing	Min	Max	Mean	StdDev
922	70,329	4,719	10,742	7,512.229	1,539.508

F33BKELBOW - F33 Broken Elbow

Col 80

Value	Description	N	%
0	No	70,069	98.3
1	Yes	1,182	1.7

F33BKELBOWDY - Days enrollment to F33 Broken Elbow

Col 81

N	Missing	Min	Max	Mean	StdDev
1,182	70,069	4,729	10,920	7,464.61	1,537.557

F33BKOTHBNX2 - F33 Broken Other Bone

Col 82

Broken other bone, Extension 2 definition.

Usage Notes:

This variable does not map to the Broken Other Bone (F33BKOTHBN) variable collected prior to Extension Study 2, as the form question changed.

Value	Description	N	%
0	No	61,695	86.6
1	Yes	9,556	13.4

F33BKOTHBNX2DY - Days enrollment to F33 Broken Other Bone

Col 83

N	Missing	Min	Max	Mean	StdDev
9,556	61,695	4,581	11,338	7,304.11	1,512.225

F33ANYFXNONHIP - F33 Any Non-Hip Fracture

Col 84

Any fracture except hip (includes other bone).

Usage Notes:

F33ANYFXNONHIP is 1 if the participant has a first event for any of the individual fracture outcomes during Ext 2

Value	Description	N	%
0	No	44,602	62.6
1	Yes	26,649	37.4

F33ANYFXNONHIPDY - Days enrollment to F33 Any Non-Hip Fracture

Col 85

Usage Notes:

Earliest F33 non-hip fracture.

N	Missing	Min	Max	Mean	StdDev
26,649	44,602	4,471	11,338	7,150.097	1,498.636

F33HYST - F33 Hysterectomy Ever

Col 86

Value	Description	N	%
0	No	68,995	96.8
1	Yes	2,256	3.2

F33HYSTDY - Days enrollment to F33 Hysterectomy Ever

Col 87

N	Missing	Min	Max	Mean	StdDev
2,256	68,995	4,709	11,025	7,152.864	1,441.174

F33OSTEOAR - F33 Osteoarthritis

Col 88

Usage Notes:

Not collected on all versions of F33.

Value	Description	N	%
0	No	50,727	71.2
1	Yes	20,524	28.8

F33OSTEOARDY - Days enrollment to F33 Osteoarthritis

Col 89

N	Missing	Min	Max	Mean	StdDev
20,524	50,727	4,543	11,300	7,241.033	1,409.37

F33INTPOLYP - F33 Intestinal Polyps

Col 90

Value	Description	N	%
0	No	63,354	88.9
1	Yes	7,897	11.1

F33INTPOLYPDY - Days enrollment to F33 Intestinal Polyps

Col 91

N	Missing	Min	Max	Mean	StdDev
7,897	63,354	4,558	11,044	7,021.832	1,408.226

F33LUPUS - F33 Lupus

Col 92

Value	Description	N	%
0	No	70,872	99.5
1	Yes	379	0.5

F33LUPUSDY - Days enrollment to F33 Lupus

Col 93

N	Missing	Min	Max	Mean	StdDev
379	70,872	4,733	9,092	6,815.293	999.921

F33PILLSHYP - F33 Pills For Hypertension

Col 94

Value	Description	N	%
0	No	60,004	84.2
1	Yes	11,247	15.8

F33PILLSHYPDY - Days enrollment to F33 Pills For Hypertension

Col 95

N	Missing	Min	Max	Mean	StdDev
11,247	60,004	4,447	11,308	7,217.627	1,555.917

F33DIABTX - F33 Diabetes Treated

Col 96

Usage Notes:

Pills or insulin shots.

Value	Description	N	%
0	No	60,649	85.1
1	Yes	10,602	14.9

F33DIABTXDY - Days enrollment to F33 Diabetes Treated

Col 97

N	Missing	Min	Max	Mean	StdDev
10,602	60,649	4,451	11,254	7,705.748	1,584.063

F33DIABINSULIN - F33 Diabetes Insulin

Col 98

Value	Description	N	%
0	No	69,307	97.3
1	Yes	1,944	2.7

F33DIABINSULINDY - Days enrollment to F33 Diabetes Insulin

Col 99

N	Missing	Min	Max	Mean	StdDev
1,944	69,307	4,577	11,053	7,461.87	1,507.171

F33DIABPILLS - F33 Diabetes Pills

Col 100

Value	Description	N	%
0	No	60,840	85.4
1	Yes	10,411	14.6

F33DIABPILLSDY - Days enrollment to F33 Diabetes Pills

Col 101

N	Missing	Min	Max	Mean	StdDev
10,411	60,840	4,451	11,254	7,714.028	1,584.818

F33DIABDIEX - F33 Diabetes Diet and/or Exercise

Col 102

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	60,583	85
1	Yes	10,668	15

F33DIABDIEXDY - Days enrollment to Diabetes Diet and/or Exercise

Col 103

N	Missing	Min	Max	Mean	StdDev
10,668	60,583	4,714	11,125	7,292.417	1,514.758

F33PARKINSONS - F33 Parkinsons

Col 104

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	69,491	97.5
1	Yes	1,760	2.5

F33PARKINSONSDY - Days enrollment to F33 Parkinsons

Col 105

N	Missing	Min	Max	Mean	StdDev
1,760	69,491	4,715	11,102	7,519.664	1,502.855

F33ALZHEIMERS - F33 Moderate or severe memory problems, dementia or Alzheimers

Col 106

Moderate or severe memory problems, dementia or Alzheimers

Usage Notes:

For version 13 of Form 33, this is a 1 if either “Moderate or severe memory problems” or “Dementia or Alzheimer’s” questions are marked. Prior to version 13 this was a single question "Moderate or severe memory problems (dementia or Alzheimers)"

Value	Description	N	%
0	No	54,031	75.8
1	Yes	17,220	24.2

F33ALZHEIMERSDY - Days enrollment to F33 Alzheimers

Col 107

N	Missing	Min	Max	Mean	StdDev
17,220	54,031	4,524	11,276	8,071.179	1,493.272

F33MACDEGEN - F33 Macular Degeneration

Col 108

Usage Notes:

Only collected during the WHI Extension Studies.

Value	Description	N	%
0	No	56,014	78.6
1	Yes	15,237	21.4

F33MACDEGENDY - Days enrollment to F33 Macular Degeneration

Col 109

N	Missing	Min	Max	Mean	StdDev
15,237	56,014	4,549	11,251	7,481.056	1,487.471

LAST33DY - Days enrollment to last form 33/33D

Col 110

Days from enrollment to last contact for outcomes information.

Usage Notes:

LAST33DY is calculated as the days from enrollment to the latest Form 33 during Extension Study 2. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33DY. LAST33DY may be missing if the ppt had no form 33s entered for extension 2.

N	Missing	Min	Max	Mean	StdDev
70,201	1,050	4,471	11,345	8,905.243	1,580.069

F33HOSPX2 - F33 Hospitalized During Extension Study 2

Col 111

Value	Description	N	%
0	No	21,539	30.2
1	Yes	49,712	69.8

F33HOSPTIMESX2 - F33 Number of Hospitalizations During Extension Study 2

Col 112

Value	Description	N	%
0	None	21,539	30.2
1	One	13,751	19.3
2	Two	11,174	15.7
3	Three or more	24,787	34.8