Cardiovascular Outcome Details (Form 121)
| File Name | Data as of | Population | Data collected | One row per | Rows |
|---|---|---|---|---|---|
| outc_cardio_inv.dat | 2/17/2024 | CT+OS | Main, Ext1, Ext2 | Outcome Form | 23,297 |
ID - WHI Participant Common ID Col 1
ASCSOURCE - Ascertainment Source Col 2
ANGINA - Angina Col 3 Usage Notes: Angina was adjudicated for CT and OS participants during the core WHI study. Angina occurring on or after a Clinical MI is not counted.
AANEUR - Aortic Aneurysm Col 4 Usage Notes: Started collecting this outcome in Ext2.
ADISSECT - Aortic Dissection Col 5 Usage Notes: Started collecting this outcome in Ext2. It is only adjudicated for the Medical Record Cohort.
CABG - CABG Col 6 Coronary Artery Bypass Graft (CABG) Usage Notes: CABG was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort.
CHF - CHF Col 7 Congestive Heart Failure (CHF) Usage Notes: CHF was adjudicated for CT and OS participants during the core WHI study.
MI - Clinical MI Col 8 Usage Notes: Clinical MI was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort.
CREVASC - Coronary Revascularization Col 9 Coronary revascularization procedure (CABG or PTCA) Usage Notes: Defined as the first occurrence of CABG or PTCA. Coronary Revascularization was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort.
HEARTVALVE - Heart Valve Disease Col 10 Moderate to severe valvular disease involving one or more valves Usage Notes: Started collecting this outcome in Ext2. It is only adjudicated for the Medical Record Cohort.
PERIPH - PAD Col 11 Peripheral Arterial Disease (PAD) Usage Notes: PAD was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort.
PTCA - PTCA Col 12 Percutaneous Transluminal Coronary Angioplasty (PTCA) Usage Notes: PTCA was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort. Includes both outpatient and inpatient PTCAs
ECGPATTR - ECG pattern Col 13 Usage Notes: Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CARDENZY - Cardiac enzyme info available Col 14 Cardiac enzyme information available? Usage Notes: Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMGE2XP - CK-MB >= 2x uln for % or index Col 15 CK-MB at least 2x upper limit of normal for % or index Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMLT2XP - CK-MB > uln & < 2x uln Col 16 CK-MB greater than upper limit of normal but less than 2x upper limit of normal for % or index Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMNORMP - CK-MB within norm % or index Col 17 CK-MB within normal limits for % or index Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMGE2XU - CK-MB >= 2x uln for units Col 18 CK-MB at least 2x upper limit of normal for units Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMLT2XU - CK-MB > uln & < 2x uln units Col 19 CK-MB greater than upper limit of normal but less than 2x upper limit of normal for units Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMNORMU - CK-MB within normal for units Col 20 CK-MB within normal limits for units Usage Notes: Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMBPRES - CK-MB `present` w/o quantification Col 21 CK-MB reported as "present” without quantification Usage Notes: Not collected after the WHI study closeout. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKMBWEAK - CK-MB `weakly present` w/o quantification Col 22 CK-MB reported as “weakly present” without quantification Usage Notes: Not collected after the WHI study closeout. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
TCKGE2X - Total CK >=2x upper limit of normal Col 23 Total CK at least 2x upper limit of normal Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
TCKLT2X - Total CK> uln & <2x uln Col 24 Total CK greater than upper limit of normal but less than 2x upper limit of normal Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
TCKNORM - Total CK within normal limits Col 25 Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CKRESNA - CK result not available Col 26 Usage Notes: Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
SERUMLDH - Serum lactate dehydrogenase Col 27 Serum lactate dehydrogenase (LDH): (Complete only if no other cardiac enzymes are available.) Usage Notes: Not collected after the WHI study closeout. Coded for MI, Coronary Death (hosp), Coronary Revascularization, Angina and CHF.
TROPLTES - Troponin Lab Test Col 28 Usage Notes: Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
TROPLRES - Troponin Lab Results Col 29 Results (Mark the one category that applies best.) Troponin values should be coded using the upper limit of normal (ULN) and not upper limit of indeterminate/indecisive as the reference value. Thus, if 2 cutpoints are given, choose the lower cutpoint for the upper limit of normal. Usage Notes: Not collected on early versions of Form 121. Coded for MI, Coronary Death (hosp) and Coronary Revascularization. Also coded for Angina and CHF before the WHI closeout.
CARDPAIN - Cardiac pain Col 30 Cardiac pain defined as: an acute episode of pain, discomfort or tightness in the chest, arm, throat or jaw Usage Notes: Only coded for MIs through the core WHI study. In Ext1 it was coded for MI, coronary death (hosp) and coronary revascularization. In Ext2 it was coded for MI, coronary revascularization, heart failure, and atrial fibrillation.
MIDX - Clinical MI Diagnosis Col 31 Usage Notes: Not collected on early versions of Form 121. An MI is defined as procedure-related if it occurs within 30 days after any procedure.
MIPROCTYP - MI Procedure Type Col 32 Usage Notes: Only coded for MIs. Only collected during Ext1 and Ext2.
MIPROCPCI - Was cardiac procedure a PCI Col 33 Usage Notes: Only coded for MIs. Started collecting in Ext2.
MIPCIENZ - For MI-PCI, Enzyme levels at least 3X uln Col 34 Were enzyme levels at least 3X ULN (99th percentile)? Usage Notes: Only coded for MIs. Started collecting in Ext2.
MIPROCCABG - Was cardiac procedure a CABG Col 35 Usage Notes: Only coded for MIs. Started collecting in Ext2.
MICABGENZ - For MI-CABG, Enzyme levels at least 5X uln Col 36 Were enzyme levels at least 5X ULN (99th percentile) and Q-Wave, new LBBB or evidence for graft closure found for CABG? Usage Notes: Only coded for MIs. Started collecting in Ext2.
MIABORT - Was MI aborted Col 37 Was the myocardial infarction aborted? (Diagnosis of an aborted MI requires: symptoms and ECG evidence for acute MI at presentation; intervention [thrombolytic therapy or a procedure] followed by resolution of ECG changes; and all cardiac enzymes within normal limits.) Usage Notes: Not collected on early versions of Form 121. Not collected after the WHI closeout. Only has values if THRMAGNT is equal to 1 or 9.
MIFATAL - Was the MI fatal Col 38 Was the myocardial infarction fatal? Usage Notes: Not collected on early versions of Form 121. Not collected after Ext1.
THRMAGNT - Thrombolytic agent or revasc procedure Col 39 Was a thrombolytic agent administered or emergent revascularization procedure (e.g., angioplasty or stent) performed? Usage Notes: Not collected on early versions of Form 121. Prior to Ext2, was only coded for MI. In Ext2 is coded for all outcomes
ANGADMT - Angina MD diagnosis & treatment this admit Col 40 Angina based on: Physician diagnosis of angina and receiving medical treatment at discharge, for angina on this admission (e.g., nitrate, beta-blocker, or calcium-channel blocker) Usage Notes: Not collected after the WHI study closeout.
ANGADMTP - Angina MD diagnosis & treament & cath hist. Col 41 Angina based on: Physician diagnosis of angina and receiving medical treatment for angina on this admission plus current medical record documenting a history of coronary heart disease by previous catheterization or revascularization procedure Usage Notes: Not collected on early versions of F121. Not collected after the WHI study closeout.
CABGOTHR - Angina CABG or other revasc this admit Col 42 Angina based on: CABG surgery or other revascularization procedure on this admission. Usage Notes: Not collected after the WHI study closeout.
ANG70GT - Angina based on >= 70% obstruc Col 43 Angina based on: 70% or greater obstruction of any coronary artery on angiography on this admission Usage Notes: Not collected after the WHI study closeout.
STSEGMNT - Angina based on ST-segment dep Col 44 Angina based on: Horizontal or down-sloping ST-segment depression or abnormal ST elevation >= 1 mm on exercise or pharmacological stress testing with pain on this admission Usage Notes: Not collected after the WHI study closeout.
STRETEST - Angina Stress test positive for ischemia Col 45 Angina based on: Scintigraphic or echocardiographic stress test positive for ischemia on this admission Usage Notes: Not collected after the WHI study closeout.
ANGECGST - Angina based on ECG STs Col 46 Angina based on: Resting ECG shows horizontal or down-sloping ST depression or abnormal ST elevation >= 1 mm with pain that is not present on ECG without pain on this admission Usage Notes: Not collected on early versions of F121. Not collected after the WHI study closeout.
CHFDXTX - CHF MD diagnosis & treatment this admit Col 47 CHF based on: Congestive failure diagnosed by physician and receiving medical treatment for CHF on this admission (e.g., diuretic, digitalis, vasodilator and/or angiotensin-converting enzyme inhibitor) Usage Notes: Not collected after the WHI study closeout.
CHFDXTXI - CHF MD Diagnosis, treatment + imaging Col 48 CHF based on: Congestive failure diagnosed by physician and receiving medical treatment on this admission plus current medical record documents a history of an imaging procedure showing impaired systolic or diastolic LV function Usage Notes: Not collected on early versions of Form 121. Not collected after the WHI study closeout.
CHFPULM - CHF Pulmonary edema chest X-ray this admit Col 49 CHF based on: Pulmonary edema\congestion by chest X-ray on this admission Usage Notes: Not collected after the WHI study closeout.
CHFDIVNT - CHF Dilated ventricle or poor left function Col 50 CHF based on: On this admission, dilated ventricle or poor left (or right-side) ventricular function (e.g., wall motion abnormalities) by echocardiography; radionuclide ventriculogram (RVG)/multigated acquisition (MUGA), or other contrast ventriculography, or evidence of left ventricular diastolic dysfunction Usage Notes: Not collected after the WHI study closeout.
CHFFATAL - CHF fatal Col 51 Was the congestive heart failure fatal? Usage Notes: Not collected after the WHI study closeout.
CORR2MI - Coronary revasc: Second MI Col 52 Second myocardial infarction (MI) (i.e., second MI not already reported in Question 4) occurring as a result of or during the revascularization procedure. Usage Notes: Not collected on early versions of Form 121. Only coded for coronary revascularizations (CABG/PTCA).
CORR2PCIENZ - For CR, PCI enzyme at least 3Xuln Col 53 For PCI, were enzyme levels at least 3X ULN (99th percentile)? Usage Notes: Only coded for Cardio Revasc. Started collecting in Ext2.
CORR2CABGENZ - For CR, Cabg enzyme at least 5Xuln Col 54 For CABG, were enzyme levels at least 5X ULN (99th percentile) and Q-Wave, new LBBB or evidence for graft closure found? Usage Notes: Only coded for Cardio Revasc. Started collecting in Ext2.
PADDX - PAD diagnosis Col 55 Diagnosis: (Mark the one category that applies best.) Usage Notes: Value 4 was not available on early versions of form 121.
PADPLAQ - Ultrasonography or angiography Col 56 PAD based on: Ultrasonographically- or angiographically-demonstrated obstruction, or ulcerated plaque (>= 50% of the diameter or >= 75% of the cross-sectional area) demonstrated on ultrasound or angiogram of the iliac arteries or below
PADABDOP - No Doppler pulse in vessels Col 57 PAD based on: Absence of pulse by doppler in any major vessel of lower extremities
PADEXER - Positive exercise test Col 58 PAD based on: Exercise test that is positive for lower extremity claudication
PADSURG - Surgery, angioplasty or thromb Col 59 PAD based on: Surgery, angioplasty, or thrombolysis for peripheral arterial disease
PADAMP - PAD Amputation of one or more toes Col 60 PAD based on: Amputation of one or more toes or part of the lower extremity because of ischemia or gangrene
PADLEG - Exertional leg pain Col 61 PAD based on: Exertional leg pain relieved by rest and at least one of the following: (1) claudication diagnosed by physician, or (2) ankle-arm systolic blood pressure ratio <= 0.8
PADULANR - Abdominal aortic aneurysm Col 62 PAD based on: Ultrasonographically- or angiographically-demonstrated abdominal aortic aneurysm Usage Notes: Not collected on early versions of Form 121. Not collected after Ext1 (see new Aortic Aneurysm outcome).
PADSRANR - Surgical/Vascular proc for AAA Col 63 PAD based on: Surgical or vascular procedure for abdominal aortic aneurysm Usage Notes: Not collected on early versions of Form 121. Not collected after Ext1 (see new Aortic Aneurysm outcome).
AADIAG - Aortic Aneurysm Diagnosis Col 64 Usage Notes: Started collecting in Ext2.
AALOCATION - Aortic Aneurysm Location Col 65 Usage Notes: Started collecting in Ext2.
ADDIAG - Aortic Disection Diagnosis Col 66 Usage Notes: Started collecting in Ext2.
HVAORTIC - Which valves? Aortic Col 67 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVAORTICDX - Aortic valve dx Col 68 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVMITRAL - Which valves? Mitral Col 69 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVMITRALDX - Mitral valve dx Col 70 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPULMON - Which valves? Pulmonic Col 71 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPULMONXDX - Pulmonic valve dx Col 72 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVTRICUSP - Which valves? Tricuspid Col 73 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVTRICUSPDX - Tricuspid valve dx Col 74 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVNOS - Which valves? NOS Col 75 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVNOSDX - Valve NOS dx Col 76 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPROC - Was a procedure or operation performed? Col 77 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPAORTIC - Aortic procedure Col 78 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPMITRAL - Mitral procedure Col 79 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPPULMONIC - Pulmonic procedure Col 80 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPTRICUS - Tricuspid procedure Col 81 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
HVPUNKNOWN - Unknown procedure Col 82 Usage Notes: Only coded for HEARTVALVE. Started collecting in Ext2.
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This file has one row for every form 121 recording outcome(s). A participant may have more than one of these forms and one form may record several different types of outcomes. Only the first occurrence of each outcome is counted, e.g. Limiting the file to rows where MI=1 will find a single row for each participant with a MI outcome. Note: strokes and carotid artery disease are in a separate file. In Ext2 cardiovascular outcomes are only adjudicated for Medical Record Cohort ppts. * ECG Data: For a summary of ECG data from CT participants, see the Feb. 2003 Progress Report, Section 6.5 ECG Data, page 6-5, for a short description, and Table 6.15 Cross-tabulation of ECG codes Suggesting an Incident MI and Locally Confirmed and Self-Reported MI, page 6-24.