​Specimen Results 

These links provide information about the blood and urine lab results currently available to investigators who are approved to access the WHI datasets:

  • Specimen Results "Read Me" Documentation - This file describes the specimen assay result data, how to use those data, and how to use/interpret the Specimen Results Descriptions - complete with examples and Q&A.

  • Specimen Results Descriptions - Descriptive information on ~300 assays from ~75 Core, BAA, and Ancillary studies. New assays will be added semi-annually as they become eligible. By selecting a specific test in the left column, you can obtain details such as the specimen type, lab, QA results and number of versions; clicking a specific version will provide the assay method. 

  • Standardization of assays from multiple labs for a given analyte - This document describes a method that uses linear regression to account for gross systematic differences in location (e.g., mean) and/or scale (e.g., standard deviation) of measurements between labs.

  • Calculation of glomerular filtration rate (eGFR) – for standardization, we recommend using the method described here.

Data Dictionaries

  
  
  
  
  
Clinic CBC ResultsCT+OSSpecimen DrawBaseline, MainPDF
Core Analyte ResultsCT+OSSpecimen DrawBaseline, MainPDF
DbGap AvailabilityCT+OSParticipantBaseline, Main, Ext1, Ext2PDF
Specimen Assay ResultsCT+OSSpecimen ResultBaseline, Main, Ext1, Ext2PDF
Specimen AssaysN/ASpecimen TestBaseline, Main, Ext1, Ext2PDF
Specimen DrawsCT+OSSpecimen DrawBaseline, Main, Ext1, Ext2PDF
Study Case-Control TypesCT+OSCase/Control typeBaseline, Main, Ext1, Ext2PDF
*Note: the Specimen Draws data file only includes draw information for the assay results included in the Specimen Assay Results data file. For urine assay results, ‘draw information’ is for urine samples brought to the clinic (or given at the clinic visit if not bringing from home). This file cannot be used to determine general sample availability. Most estimates of sample availability can be calculated by using the Query Builder.

 

Key Tests

 

Source​ Population Tests #
Clinic Tests​
  • All enrolled CT and OS participants at baseline (W1) ^
  • OS participants at Year 3 (W1)
  • Hemoglobin
  • Hematocrit
  • White Blood Cell Count
  • Platelet Count
Core Study Analytes
  • 6% CT Subsample* at Baseline, Year 1, Year 3, and Year 6 (W1)
  • 1% OS Measurement and Precision Study* at Baseline and 3-months (W2)
  • Lipids, including subfractions
  • Glucose/Insulin
  • Coagulation factors
  • Micronutrients
CVD Biomarker Subsample
  • A subset of approximately 25,000 participants have CVD biomarkers measured at WHI baseline (W1, W54, and W58).  The composition of the subsample is described in this flowchart.
  • Lipids
  • Glucose/Insulin

^The baseline CBC results are the only test results available for the entire WHI population.
*A description of the CT Subsample and the OS Measurement and Precision Study populations may be found here.

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