Franceschini N, Kopp JB, Barac A, Martin LW, Li Y, Qian H, Reiner AP, Pollak M, Wallace RB, Rosamond WD, Winkler C.
APOL1 genotypes are associated with kidney diseases in African Americans and may associate with cardiovascular disease in postmenopausal women, who are at high-risk for these outcomes. Among 11,137 African American participants of the Women's Health Initiative, APOL1 genotypes were not associated with incident coronary heart disease, ischemic stroke, and all-cause and cardiovascular mortality. APOL1 was associated with hospitalized heart failure with preserved ejection fraction, which was partly accounted by baseline kidney function. This study does not support a relationship among APOL1 genotypes and cardiovascular disease in postmenopausal women, except for heart failure with preserved ejection fraction, which mechanisms may include chronic kidney disease.