Jacques Rossouw, chief of the WHI Branch in the Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute (NHLBI), is retiring after a long and illustrious career. Jacques has been a champion for WHI from the study's beginning. He made a case for the hormone trial, guided the development of the protocol and funding mechanism, and oversaw the recruitment of the various sites and their performance. Jacques steered the study through unprecedented events surrounding the stopping of the hormone trials in 2002, and he transitioned the program into a broader scientific resource. In 2006 Jacques was included on the annual list assembled by Time of the 100 most influential people in the world, whose power, talent, or moral example is transforming our world. Jacques plans to return to NHLBI in a part-time capacity after an extended time off, as long as it doesn't interfere with time on his boat. WHI wishes Jacques a bon voyage!